Covid-19: AstraZeneca vaccine linked with small risk of ITP, real world data show

Wise, Jacqui

doi:10.1136/bmj.n1489

Cited by 7 publications

(9 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While mRNA COVID-19 vaccination is absolutely essential for preventing COVID-19 [ 1 , 11 ], autoimmune cytopenia following COVID-19 vaccination has been increasingly reported. Most studies demonstrated the occurrence of thrombocytopenia or progression of ITP [ 3 – 5 ]. Two recent studies have presented cases of AIHA two days and three weeks after receiving the second dose of the mRNA COVID-19 vaccine [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

et al. 2021

View full text Add to dashboard Cite

Evans syndrome presents as concurrent autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Systemic lupus erythematosus (SLE) is the most frequent autoimmune disorder associated with Evans syndrome. We herein report a case of new-onset Evans syndrome associated with SLE after BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccination in a 53-year-old woman. Blood examination at diagnosis showed hemolytic anemia with a positive Coombs test and thrombocytopenia. Hypocomplementemia and the presence of lupus anticoagulant indicated a strong association with SLE. Prednisolone administration rapidly restored hemoglobin level and platelet count. This case suggests that mRNA COVID-19 vaccination may cause an autoimmune disorder. Physicians should be aware of this adverse reaction by mRNA COVID-19 vaccination and should consider the benefits and risks of vaccination for each recipient.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In a phase 3 trial, this vaccine showed 95% efficacy in preventing symptomatic SARS-CoV-2 infection [ 1 ]. On the other hands, recent studies have indicated that mRNA vaccination against COVID-19 is associated with onset and progression of autoimmune hematologic disorders, especially immune thrombocytopenia [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

et al. 2021

View full text Add to dashboard Cite

show abstract

“…At the time of this case, the Centers for Disease Control was recommending a two-dose primary series for those 5–17 years of age (Pfizer and Moderna) and booster vaccine for those who had received the Pfizer vaccine [ 17 ]. However, COVID-19 vaccination has been linked with rare autoimmune-mediated adverse events, and thus it s important to be aware of potential associations given the limited data on rare adverse events with these vaccinations [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Presentation of SLE after COVID vaccination in a pediatric patient

et al. 2022

View full text Add to dashboard Cite

Background The outbreak of severe acute respiratory syndrome coronavirus 2 has had an enormous impact on global health. Vaccination remains one of the most effective interventions for disease prevention. Clinically significant vaccine side effects are uncommon, though autoimmune-mediated disease occurs in a small percentage of vaccine recipients. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that is associated with significant morbidity and mortality. Childhood-onset SLE tends to have more severe disease manifestations than adult-onset SLE. In adults, there are a few reported cases of SLE developing soon after coronavirus disease 2019 (COVID-19) mRNA vaccination. Case presentation A 14-year-old previously healthy male developed laboratory and clinical evidence of SLE, including maculopapular malar rash, arthritis, pleuritic chest pain, and class V (membranous) lupus nephritis, 2 days after his third dose of the Pfizer-BioNTech COVID-19 vaccine. The patient’s symptoms improved after initiation of prednisone and mycophenolate mofetil. We also summarize eleven prior case reports describing SLE after COVID-19 vaccine in adults. Conclusion To our knowledge, this is the first reported pediatric patient with new onset SLE following COVID-19 mRNA vaccination. While potential mechanistic links exist between COVID-19 vaccination and SLE development, additional studies are necessary to elucidate the exact nature of this relationship.

show abstract

“…SARS-CoV2 mRNA vaccines have been shown to be effective in preventing COVID-19 infection. However, the vaccine has been associated with flares of autoimmune haematological disorders [1][2][3] and autoimmune conditions like SLE [4]. In this patient, the SARS-CoV2 vaccine had triggered an SLE flare with a new manifestation of ES, in an individual whose disease activity was previously only marked by intermittent thrombocytopenia and was under control with immunosuppressants.…”

Section: Dear Editormentioning

confidence: 98%

New-onset Evans syndrome in a patient with SLE post SARS-CoV2 mRNA vaccination

Teo

et al. 2022

Ann Hematol

View full text Add to dashboard Cite

Covid-19: AstraZeneca vaccine linked with small risk of ITP, real world data show

Cited by 7 publications

References 1 publication

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination

Presentation of SLE after COVID vaccination in a pediatric patient

New-onset Evans syndrome in a patient with SLE post SARS-CoV2 mRNA vaccination

Contact Info

Product

Resources

About