2021
DOI: 10.1016/j.ajem.2020.06.059
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COVID-19 associated parotitis

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Cited by 49 publications
(57 citation statements)
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“…Chen et al revealed the expression of ACE2 receptor in human granular cells in salivary glands, which can actually be a target site for 2019‐nCoV 4 . Fisher et al reported parotitis in a diagnosed case of COVID‐19 5 …”
Section: Figurementioning
confidence: 99%
“…Chen et al revealed the expression of ACE2 receptor in human granular cells in salivary glands, which can actually be a target site for 2019‐nCoV 4 . Fisher et al reported parotitis in a diagnosed case of COVID‐19 5 …”
Section: Figurementioning
confidence: 99%
“…Salivary sample has been frequently confirmed that SARS-CoV-2 is predominantly present in saliva due to the high expression of Angiotensin-converting enzyme 2 receptor in the epithelial lining of the salivary glands and cellular viral entry. 10 A study demonstrated a high yield (91.7%) of positive COVID-19 results in patients' saliva with most of the samples also culturing the live virus. 11 This finding strongly suggest that salivary gland is a possible target for SARS-CoV-2 infection.…”
Section: Discussionmentioning
confidence: 99%
“…Since ACE2 is expressed by acinar epithelial cells of major and minor salivary glands [221], some authors have hypothesized the development of acute sialadenitis during SARS-CoV-2 infection phase and chronic sialadenitis after recovery [296]. This hypothesis has been supported by series of case reports of acute parotitis and submandibular gland sialadenitis in middle-aged to elderly COVID-19 patients [297][298][299]. Altogether, this supports a possible direct link between SARS-CoV-2 infection and sialadenitis, but further investigations are needed in order to establish this relationship, such as eliminating all other viral co-infections of salivary glands and expand clinical observations to larger cohorts of COVID-19 patients.…”
Section: Q39-what Are the Main Oral Manifestations Of Covid-19?mentioning
confidence: 92%