COVID-19-associated opportunistic infections: a snapshot on the current reports

Abdoli, Amir; Falahi, Shahab; Kenarkoohi, Azra

doi:10.1007/s10238-021-00751-7

Cited by 92 publications

(119 citation statements)

References 284 publications

(461 reference statements)

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“…Immunosuppressive therapy is considered an important risk factor for opportunistic infections in COVID-19 patients. Corticosteroids are immunosuppressive drugs commonly prescribed for these patients [3] , as seen in the current case report. Besides that, the patient also received long-term antibiotics, which probably altered her oral microbiota.…”

Section: Discussionmentioning

confidence: 64%

“…There is not enough information on COVID-19-associated opportunistic infections to date; however, the most common in critical patients are those affecting the respiratory tract, bloodstream, and urinary tract [2] . Moreover, fungal infections are the most frequently reported, followed by viral, bacterial, protozoa, and helminth ones [3] .…”

Section: Introductionmentioning

confidence: 99%

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Phototherapies for COVID-19-associated opportunistic oral infections

Berlingieri¹,

Alvares

Serrano

et al. 2022

Photodiagnosis and Photodynamic Therapy

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Opportunistic infections are widely described in patients with novel coronavirus disease 2019 (COVID-19); however, very few studies have addressed those affecting the oral cavity. Given the lack of information on the clinical presentations and the available treatment options, the present study aimed to show a case in which a combination of antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT) was used for the management of two concomitant COVID-19-associated opportunistic oral infections (oral pseudomembranous candidiasis and recurrent herpes labialis). Within 7 days and without any systemic drug administration, all the lesions resolved completely, and the patient no longer reported oral pain or discomfort. According to the current case report and taking into consideration the significant gaps in the knowledge and understanding of COVID-19, this combination of phototherapy modalities seems to be a promising tool for managing viral and fungal opportunistic oral infections.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Phototherapies for COVID-19-associated opportunistic oral infections

Berlingieri¹,

Alvares

Serrano

et al. 2022

Photodiagnosis and Photodynamic Therapy

View full text Add to dashboard Cite

show abstract

“…Immunosuppressive therapy has shown promising results for control of the cytokine storm syndrome in severe cases of COVID-19. However, it is well documented that immunosuppressive agents (e.g., corticosteroids) increase the risk of opportunistic infections [5]. In our case description, despite that it was a man without comorbidities, the patient with COVID-19 is admitted to the hospital with a serious hypoxemic respiratory insufficiency, starts corticosteroid therapy with dexamethasone, is transferred to the ICU, and initiates invasive mechanical ventilation treatment on the admission day that we believe has significantly contributed to increasing the risk of health care-associated infection (HAI) development.…”

Section: Discussionmentioning

confidence: 99%

“…In severe cases, COVID-19 can be complicated by acute respiratory distress syndrome (ARDS), sepsis and septic shock, and multi-organ failure [2][3][4]. Several opportunistic infections were reported among COVID-19 patients [5], despite that its real impact is not completely understood. Some studies report Aspergillus spp., Candida spp., Cryptococcus neoformans, Pneumocystis jiroveci (carinii), Cytomegalovirus, Herpes simplex virus, Mycobacterium tuberculosis, and Toxoplasma gondii as the main opportunistic infections [5], while others studies report scarce (<10%) fungal, viral and bacterial co-infections [6].…”

Section: Introductionmentioning

confidence: 99%

“…Several opportunistic infections were reported among COVID-19 patients [5], despite that its real impact is not completely understood. Some studies report Aspergillus spp., Candida spp., Cryptococcus neoformans, Pneumocystis jiroveci (carinii), Cytomegalovirus, Herpes simplex virus, Mycobacterium tuberculosis, and Toxoplasma gondii as the main opportunistic infections [5], while others studies report scarce (<10%) fungal, viral and bacterial co-infections [6]. The most common bacteria described were Mycoplasma pneumonia, Pseudomonas aeruginosa, and Haemophilus influenzae [6], despite the increasing reports of multidrug-resistant Gram-negative pathogens [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Hafnia alvei Pneumonia: A Rare Cause of Infection in a Patient with COVID-19

2021

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Herein, we describe a case report of a critically ill patient, a 48-year-old man without comorbidities admitted to the hospital with a serious type 1 (hypoxemic) respiratory insufficiency and confirmed diagnosis of COVID-19. After 5 days with invasive mechanical ventilation, the patient developed a bacterial co-infection, namely a pneumonia by Hafnia alvei, requiring the last line of respiratory support: extracorporeal membrane oxygenation (ECMO). Subsequently, his clinical situation gradually stabilized, until he was discharged from the hospital on day 61, being accompanied in ambulatory consultation by the physical medicine and pulmonology department during the post-COVID-19 recovery. H. alvei is a Gram-negative bacterium that is rarely isolated from human specimens and is rarely considered to be pathogenic. However, COVID-19 disease can cause substantial organ dysfunction and can be associated with bacterial secondary infections which can favor the emergence of rare infectious diseases by uncommon microorganisms.

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Synthesis, SARS‐CoV‐2 3CL main protease inhibitor, anti‐inflammatory, and wound‐healing effects of a zinc(II)‐thiosemicarbazone complex

Arslan

Kaya

Ülküseven

2023

Applied Organom Chemis

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A new zinc(II) complex with tetradentate thiosemicarbazone (2) was synthesized to investigate the effectiveness against SARS-CoV-2 virus and its antiinflammatory effects on BEAS-2B human bronchial epithelial cells. Structural confirmation was performed by IR, 1 H and 13 C NMR, and ESI-MS spectroscopies. The results showed that the complex 2 molecule inhibits 3CL main protease enzyme. It was found that complex 2 had a proliferative effect at low doses. TNF-α stimulation significantly increased IL8 gene expression 3.42 ± 0.107 fold in BEAS-2B cells (p = 0.037). However, it was found that all concentrations of complex 2 highly suppressed IL8 gene expression in the control group and TNF-α-stimulated BEAS-2B cells (p = 0.009). The healing rate of complex 2 was higher than the control and BEAS-2B cells induced by TNF-α at the 24 and 48 h after wound formation. It is known that the biological efficiency of metal-thiosemicarbazone complexes was adjusted depending on substituent and metal. In this context, complex 2 may be considered as a precursor molecule in the investigation of the antiviral and anti-inflammatory effects of those formed with the element zinc. Investigation of the selectivity of the inhibitory effect of complex 2 on the 3CL main protease is important for a more detailed understanding of its antiviral effect potential. Although the 3CL main protease enzyme was concentrated in antiviral effective molecule screening studies against SARS-CoV-2 virus, the fact that complex 2 also has antiinflammatory and wound-healing effects is a distinguishing feature from other inhibitory effective molecules.

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COVID-19-associated opportunistic infections: a snapshot on the current reports

Cited by 92 publications

References 284 publications

Phototherapies for COVID-19-associated opportunistic oral infections

Phototherapies for COVID-19-associated opportunistic oral infections

Hafnia alvei Pneumonia: A Rare Cause of Infection in a Patient with COVID-19

Synthesis, SARS‐CoV‐2 3CL main protease inhibitor, anti‐inflammatory, and wound‐healing effects of a zinc(II)‐thiosemicarbazone complex

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