COVID-19-associated ophthalmoparesis and hypothalamic involvement

Pascual-Goñi, Elba; Fortea, Juan; Martínez‐Domeño, Alejandro; Rabella, N; Tecame, Mario; Gómez-Oliva, Cristina; Querol, Luís; Gómez‐Anson, Beatriz

doi:10.1212/nxi.0000000000000823

Cited by 71 publications

(81 citation statements)

References 10 publications

(9 reference statements)

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“…of patients Mean Age of the patients(Range) Notes Cranial Nerve abnormalities 1 Impaired Eye movement 4 Articles [ 57 ], [ 58 ], [ 194 ], [ 215 ] 12 NR in all articles. Pascual-Goñi E et al [ 194 ], reported a 36 Y/O F and bilateral sixth nerve palsy with impression of Wernicke encephalopathy. Dinkin M et al [ 215 ], reported a 36 Y/O M and third nerve palsy and impression of Miller-Fisher syndrome.…”

Section: Resultsmentioning

confidence: 99%

“…Impaired Eye movement associated with COVID-19 was described in 12 patients out of 4 studies. (Table 4) Pascual-Goñi E et al [194], reported a 60-year-old woman with right abducens nerve palsy. In brain MRI examination, FLAIR hyper-intensity of the pontine tegmentum and right sixth cranial nerve nucleus was noted.…”

Section: Cns Vasculitismentioning

confidence: 99%

“…Pascual-Goñi E et al [194] [63], [101], [191], [215], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229] Abbreviation: M: Male, F: Female, NR: Not reported Abbreviation: M: Male, F: Female, NR: Not reported J et al [127], reported a 69-year-old woman with acute necrotizing myelitis. Optic Neuritis after COVID-19 was reported in only one patient.…”

Section: ] Sotocamentioning

confidence: 99%

“…[126] In the recent reported patients, post-infectious etiology in terms of secondary immunogenic overreaction was proposed as the underlying mechanism for myelitis after COVID-19. [ [58], [194], [215] 12 NR in all articles.…”

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confidence: 99%

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Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

183

182

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Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. Methods: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. Results: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. Conclusion: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely.

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Section: Resultsmentioning

confidence: 99%

Section: Cns Vasculitismentioning

confidence: 99%

Section: ] Sotocamentioning

confidence: 99%

mentioning

confidence: 99%

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Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

183

182

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“…In particular, more than one study describes magnetic resonance signal abnormalities at the olfactory bulbs and tracts, as well as the orbital‐frontal and gyrus rectus cortex (88–90). In addition, fluid attenuated inversion recovery (FLAIR) hyperintensities have been reported on magnetic resonance imaging in the brainstem (pontine tegmentum, including VI cranial nerve nuclei), thalami, medial temporal lobes, mammillary bodies, and hypothalamus; a swollen upper pituitary stalk with a globular appearance has also been described (91).…”

Section: Neuroradiological Findingsmentioning

confidence: 99%

Neuroinvasive potential of SARS‐CoV2 with neuroradiological and neuropathological findings: is the brain a target or a victim?

Franca

Ugga

Guadagno

et al. 2020

APMIS

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Coronaviridae family includes pathogen viruses for humans, that lead to clinical conditions with main respiratory involvement; many of these viruses have notoriously a neuroinvasive potential, as demonstrated by published data on SARS‐CoV and MERS‐CoV epidemics, as well by results obtained in experimental models. During pandemic of coronavirus disease 2019 (COVID‐19), it is noticed that the central nervous system involvement represented a truly significant moment in the history of some COVID‐19 patients; indeed, clinical and radiological features published in literature regarding COVID‐19 disease are consistent with a neurological involvement. It is also known that histopathological data related to SARS‐CoV2 infection have been published with considerable delay, which was even greater for neuropathological information. Moreover, many published data are incomplete, and often the lesions described are not directly related to the action of the virus. In this review, we collected the available radiological and neuropathological information, in order to delineate a more complete picture of the relationship between SARS‐Cov2 and brain, focusing our attention on the two most important neuroinvasion routes for the virus. We also highlighted what we consider methodological mistakes both in the autopsy procedures and brain study in COVID‐19 deaths. We emphasize the need for a complete study of all the organs in case of autopsy. It is important that through this experience, we no longer do the mistake of neglecting the brain.

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SARS‐CoV‐2 infection and paediatric endocrine disorders: Risks and management considerations

Ashraf

Gourgari

et al. 2021

Endocrino Diabet & Metabol

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Background Coronavirus‐19 (COVID‐19) is a disease caused by the SARS‐CoV‐2 virus, the seventh coronavirus identified as causing disease in humans. The SARS‐CoV‐2 virus has multiple potential pathophysiologic interconnections with endocrine systems, potentially causing disturbances in glucose metabolism, hypothalamic and pituitary function, adrenal function and mineral metabolism. A growing body of data is revealing both the effects of underlying endocrine disorders on COVID‐19 disease outcome and the effects of the SARS‐CoV‐2 virus on endocrine systems. However, comprehensive assessment of the relationship to endocrine disorders in children has been lacking. Content In this review, we present the effects of SARS‐CoV‐2 infection on endocrine systems and review the current literature on complications of COVID‐19 disease in underlying paediatric endocrine disorders. We provide recommendations on management of endocrinopathies related to SARS‐CoV‐2 infection in this population. Summary and outlook With the surge in COVID‐19 cases worldwide, it is important for paediatric endocrinologists to be aware of the interaction of SARS‐CoV‐2 with the endocrine system and management considerations for patients with underlying disorders who develop COVID‐19 disease. While children and adults share some risk factors that influence risk of complications in SARS‐CoV‐2 infection, it is becoming clear that responses in the paediatric population are distinct and outcomes from adult studies cannot be extrapolated. Evidence emerging from paediatric studies provides some guidance but highlights the need for more research in this area.

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COVID-19-associated ophthalmoparesis and hypothalamic involvement

Cited by 71 publications

References 10 publications

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Neuroinvasive potential of SARS‐CoV2 with neuroradiological and neuropathological findings: is the brain a target or a victim?

SARS‐CoV‐2 infection and paediatric endocrine disorders: Risks and management considerations

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