COVID-19 associated nervous system manifestations

Khatoon, Fahmida; Prasad, Kartikay; Kumar, Vijay

doi:10.1016/j.sleep.2021.07.005

Cited by 28 publications

(27 citation statements)

References 90 publications

(107 reference statements)

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“…Secondly, SARS-CoV-2 may enter the central nervous system via retrograde axonal transport using the peripheral nerve terminals, for example, the terminal olfactory nerve or the enteric nervous system. Finally, viral entry could also be facilitated by infected macrophages and monocyte, which behave as carriers [ 59 , 60 , 61 ]. It has been demonstrated via mRNA and protein expression that ACE2 is present on the dorsal root ganglia (DRG) in the skin, luminal organs, and meninges.…”

Section: Neuronal Sensitization In Covid-19 Patientsmentioning

confidence: 99%

COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Lauwers

Yuan

et al. 2022

IJMS

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COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends have shifted from acute effects towards the long-term morbidity of COVID-19. In this review, we hypothesize that SARS-CoV-2 contributes to age-related perturbations in endothelial and adipose tissue, which are known to characterize the early aging process. This would explain the long-lasting symptoms of SARS-CoV-2 as the result of an accelerated aging process. Connective tissues such as adipose tissue and musculoskeletal tissue are the primary sites of aging. Therefore, current literature was analyzed focusing on the musculoskeletal symptoms in COVID-19 patients. Hypovitaminosis D, increased fragility, and calcium deficiency point towards bone aging, while joint and muscle pain are typical for joint and muscle aging, respectively. These characteristics could be classified as early osteoarthritis-like phenotype. Exploration of the impact of SARS-CoV-2 and osteoarthritis on endothelial and adipose tissue, as well as neuronal function, showed similar perturbations. At a molecular level, this could be attributed to the angiotensin-converting enzyme 2 expression, renin-angiotensin system dysfunction, and inflammation. Finally, the influence of the nicotinic cholinergic system is being evaluated as a new treatment strategy. This is combined with the current knowledge of musculoskeletal aging to pave the road towards the treatment of long-term COVID-19.

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Section: Neuronal Sensitization In Covid-19 Patientsmentioning

confidence: 99%

COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Lauwers

Yuan

et al. 2022

IJMS

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“…The COVID-19 pandemic is a serious threat to public health, and not only because of the deaths numbering in the hundreds of thousands, but also because of the post-COVID-19 conditions that have complicated the lives of millions of people after they were infected. Complications of COVID-19 include autoimmune, cardiological, oncological, neurological, and chronic inflammatory conditions [210,211]. Public health systems around the world face a difficult task of rehabilitating hundreds of millions of people afflicted by COVID-19.…”

Section: Perspectives For the Applications Of The Antioxidant Properties Of Probiotic Lactobacilli And Bifidobacteriamentioning

confidence: 99%

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

et al. 2021

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Lactobacilli and bifidobacteria are an important part of human gut microbiota. Among numerous benefits, their antioxidant properties are attracting more and more attention. Multiple in vivo and in vitro studies have demonstrated that lactobacilli and bifidobacteria, along with their cellular components, possess excellent antioxidant capacity, which provides a certain degree of protection to the human body against diseases associated with oxidative stress. Recently, lactobacilli and bifidobacteria have begun to be considered as a new source of natural antioxidants. This review summarizes the current state of research on various antioxidant properties of lactobacilli and bifidobacteria. Special emphasis is given to the mechanisms of antioxidant activity of these bacteria in the human gut microbiota, which involve bacterial cell components and metabolites. This review is also dedicated to the genes involved in the antioxidant properties of lactobacilli and bifidobacteria strains as indicators of their antioxidant potential in human gut microbiota. Identification of the antioxidant biomarkers of the gut microbiota is of great importance both for creating diagnostic systems for assessing oxidative stress and for choosing strategies aimed at restoring the normal functioning of the microbiota and, through it, restoring human health. In this review, the practical application of probiotic strains with proven antioxidant properties to prevent oxidative stress is also considered.

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“…Segundo Khatoon (2022) O caminho direto para a neuroinvasão seria neuronal, conforme Lopez-Hortua (2022) descreve. Taga (2022) relata a hipótese do nervo olfatório, trigêmeo e os receptores gustativos serem rotas de entrada para o vírus e Vakili (2021) relata que a placa cribriforme do etmoide pode ser outra porta de entrada.…”

Section: Discussionunclassified

Investigação de manifestações neurológicas em pacientes admitidos com infecção COVID-19 no Hospital de Urgência de Teresina

Portela

Policarpo

2022

RSD

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Objetivo: analisar a frequência de manifestações neurológicas da COVID-19 em pacientes internados no Hospital de Urgência de Teresina, descrevendo as diferentes manifestações neurológicas e suas correlações com idade, sexo e histórico de hipertensão e diabetes. Metodologia: Trata-se de um estudo transversal, descritivo e quantitativo realizado durante os meses de junho de 2021 a abril de 2022. A coleta de dados ocorreu no serviço de arquivamento de prontuários (SAME) no Hospital de Urgência de Teresina (HUT) em Teresina-PI durante os meses de agosto e setembro de 2021. Para a pesquisa, analisou-se 253 prontuários de pacientes diagnosticados com COVID-19, selecionados aleatoriamente entre os 736 atendidos no HUT entre 1º de março de 2020 e 30 de setembro de 2020. Variáveis analisadas: diagnóstico de COVID-19, teste diagnóstico, idade, sexo, presença de manifestações neurológicas, diabetes, hipertensão. Resultado: 50,2% dos prontuários analisados possuíam manifestações neurológicas, sendo catalogadas 40 sintomas neurológicos diferentes. Não foi possível estabelecer uma relação estatística entre idade, sexo e presença de hipertensão arterial sistêmica com os sintomas neurológicos, mas há evidências sobre a diabetes mellitus influenciar a presença dos sintomas catalogados. Conclusão: Os sintomas neurológicos possuem presença considerável para o estabelecimento da doença e sua evolução, sendo RNC, convusões, anosmia e ageusia os mais comuns. Foi possível correlacionar a presença de diabetes com os sintomas apresentados. Os sintomas neurológicos apresentam ligações diretas com a invasão neurológica do COVID-19.

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COVID-19 associated nervous system manifestations

Cited by 28 publications

References 90 publications

COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

Biomarkers and Utility of the Antioxidant Potential of Probiotic Lactobacilli and Bifidobacteria as Representatives of the Human Gut Microbiota

Investigação de manifestações neurológicas em pacientes admitidos com infecção COVID-19 no Hospital de Urgência de Teresina

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