COVID-19 associated Kawasaki-like multisystem inflammatory syndrome in an adult

Elouardi, Youssef; Rebahi, Houssam; Zarrouki, Youssef; Ziadi, Amra; Younous, S.; Samkaoui, M.A.

doi:10.1016/j.redare.2020.11.009

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…The school age group was predominantly affected in this cohort as seen in earlier studies which documented older children than those usually affected in typical KD. 5 , 17 , 26 There are infrequent reports of the occurrence of the syndrome in adults 27 and male preponderance has also been shown in several study groups 26 , 28 , 29 as was seen in our cohort.…”

Section: Discussionsupporting

confidence: 82%

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

et al. 2022

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Section: Discussionsupporting

confidence: 82%

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

et al. 2022

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“…Understanding the dynamics of COVID-19-associated microbiome alterations may help identify microbiome-based strategies with potential applications in COVID-19 management and treatment. Furthermore, our findings highlight that non-invasive organ and/or system-based microbiome profiling may serve not only for COVID-19 diagnosis and prognosis but also, for the identification of individuals at risk of secondary infections, chronic disease, and/or degenerative inflammatory symptoms, including Kawasaki-like disease (KLD) and multisystem inflammation, as is the case with children and young adults ( Akca et al., 2020 ; Cheung et al., 2020 ; Sokolovsky et al., 2021 ; Elouardi et al., 2022 ).…”

Section: Discussionmentioning

confidence: 90%

COVID-19 alters human microbiomes: a meta-analysis

Reuben

Beugnon

Jurburg

2023

Front. Cell. Infect. Microbiol.

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IntroductionSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected a substantial portion of the world’s population, and novel consequences of COVID-19 on the human body are continuously being uncovered. The human microbiome plays an essential role in host health and well-being, and multiple studies targeting specific populations have reported altered microbiomes in patients infected with SARS-CoV-2. Given the global scale and massive incidence of COVID on the global population, determining whether the effects of COVID-19 on the human microbiome are consistent and generalizable across populations is essential.MethodsWe performed a synthesis of human microbiome responses to COVID-19. We collected 16S rRNA gene amplicon sequence data from 11 studies sampling the oral and nasopharyngeal or gut microbiome of COVID-19-infected and uninfected subjects. Our synthesis included 1,159 respiratory (oral and nasopharyngeal) microbiome samples and 267 gut microbiome samples from patients in 11 cities across four countries.ResultsOur reanalyses revealed communitywide alterations in the respiratory and gut microbiomes across human populations. We found significant overall reductions in the gut microbial diversity of COVID-19-infected patients, but not in the respiratory microbiome. Furthermore, we found more consistent community shifts in the gut microbiomes of infected patients than in the respiratory microbiomes, although the microbiomes in both sites exhibited higher host-to-host variation in infected patients. In respiratory microbiomes, COVID-19 infection resulted in an increase in the relative abundance of potentially pathogenic bacteria, including Mycoplasma.DiscussionOur findings shed light on the impact of COVID-19 on the human-associated microbiome across populations, and highlight the need for further research into the relationship between long-term effects of COVID-19 and altered microbiota.

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“…summarizes the study selection process. We excluded 8 articles: 3 were not in English, 3 could not be located, 1 abstract did not have enough data for inclusion, and 1 reported case was deemed a misdiagnosis by 2 clinicians (P.P. and J.D.)…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults

et al. 2021

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Key Points Question What are the clinical characteristics of multisystem inflammatory syndrome in adults (MIS-A)? Findings This systematic review of patients with MIS-A reported in the literature and to the US Centers for Disease Control and Prevention identified 221 patients worldwide. The syndrome presented approximately 4 weeks after acute COVID-19 with hyperinflammation and extrapulmonary multiorgan involvement that may be difficult to discern from acute biphasic COVID-19 and postacute sequelae of SARS-CoV-2 infection. Meaning These findings suggest that MIS-A occurs in the postacute COVID-19 period with a heterogeneous clinical presentation likely owing to a dysregulated immune response.

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COVID-19 associated Kawasaki-like multisystem inflammatory syndrome in an adult

Cited by 8 publications

References 8 publications

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

Clinical presentation and short-term outcomes of multisystemic inflammatory syndrome in children in Lagos, Nigeria during the COVID-19 pandemic: A case series

COVID-19 alters human microbiomes: a meta-analysis

Clinical Characteristics of Multisystem Inflammatory Syndrome in Adults

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