COVID-19-associated<i>Staphylococcus aureus</i>cavitating pneumonia

Chandran, Shruthi; Avari, Malcolm; Cherian, Benny P; Suárez, Cristina

doi:10.1136/bcr-2021-243726

Cited by 9 publications

(4 citation statements)

References 10 publications

(12 reference statements)

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“…Viral pneumonia-causing cavitation is relatively uncommon [ 2 ]. Staphylococcus aureus , a known cause of community and hospital-associated infections was a major cause of mortality during the 1918 and 2009 influenza pandemics and is often seen as a secondary infection or superinfection but rarely seen as a coinfection in immunocompetent patients such as in this case [ 3 ]. Researchers have discovered that some MRSA strains contain genes for the Panton-Valentine leucocidin (PVL) toxin which has been shown to be responsible for many of the severe clinical symptoms of infection including severe necrotizing pneumonia and necrotic lesions of the skin and soft tissue [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Cavitary Lesion in Lung

Vangara¹,

Rahmlow²,

Gullapalli³

et al. 2023

Cureus

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The clinical manifestations of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are widespread, ranging from asymptomatic to critical illness with significant morbidity and mortality. It is widely known that individuals who have viral respiratory infections are more likely to develop bacterial infections. Throughout the pandemic, despite the fact that COVID-19 was thought to be the primary cause of millions of deaths, bacterial coinfections, superinfections, and other secondary complications played a significant role in the increased mortality rate. In our case, a 76-year-old male presented to the hospital complaining of shortness of air. Polymerase chain reaction (PCR) testing was positive for COVID-19 and cavitary lesions were discovered on imaging. Treatment was guided based on the results of bronchoscopy with bronchoalveolar lavage (BAL) cultures showing methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium gordonae. However, the case was later complicated by the development of a pulmonary embolism after anticoagulants were held due to new onset hemoptysis. Our case highlights the importance of considering bacterial coinfection in cavitary lung lesions, appropriate antimicrobial stewardship, and close follow-up for full recovery in COVID-19 infections.

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Section: Discussionmentioning

confidence: 99%

COVID-19 and Cavitary Lesion in Lung

Vangara¹,

Rahmlow²,

Gullapalli³

et al. 2023

Cureus

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“…Recent studies show that there is an increase in MRCoNS infections with rising COVID-19. MRSA is among the most frequent causative agents of pulmonary infection in patients with COVID-19 (Chandran et al, 2021;Bassetti et al, 2022). This might be due to immune compromisation, immune-related pathways and gene dysregulation in COVID-19 patients (Türk et al, 2020;Malkan et al, 2021;Türk et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance patterns of methicillin-resistant coagulase negative staphylococci isolated from blood cultures at a university hospital in Turkey

Türk¹,

Göçer²,

Yılmaz³

et al. 2022

MJM

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Aims:Recent reports indicate that many coagulase-negative staphylococci (CoNS) strains are resistant to most antimicrobials used against staphylococcal infections. This study was aimed to determine the species distribution of the CoNS isolates in Lokman Hekim Ankara Hospital and determine their antimicrobial resistance characteristics. Methodology and results:The study was conducted at Lokman Hekim University Ankara Hospital between February 2020 and August 2021. The 154 blood cultures included in the study were incubated in the BACTEC FX40 automated blood culture device. Identification and antimicrobial susceptibility tests of the samples with positive catalase tests were performed with the BD Phoenix Automated Microbiology Sensitivity System. The statistical significance level was accepted as p<0.05. Nineteen different types of methicillin-resistant coagulase-negative staphylococci (MRCoNS) isolated from different age groups were identified. Vancomycin resistance was observed in 20 samples (13%). Trimethoprim-sulfamethoxazole (TMP-SMX) resistance was seen in 44 of 152 samples (28.6%), linezolid resistance in 15 of 143 samples (10.5%) and daptomycin resistance in 16 of 146 blood samples (11%). Conclusion, significance and impact of study: In our investigation, there has been a striking rise in the prevalence of vancomycin, TMP-SMX, linezolid and daptomycin resistance among infections with the MRCoNS. Identifying and classifying multidrug resistance on MRCoNS requires reliable epidemiological data to be collected and compared between healthcare facilities in different countries. The research finding reported in this paper will contribute to the determination of alternative antibiotics for treating MRCoNS.

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“…Increased toxin production justifies the use of antibiotics for the treatment of necrotising pneumonia caused by this organism. Infection appears to be less common in patients with COVID-19 (7–14%) than in those with PVL-producing pneumonia, which has been described as a complication of this virus [ 124 , 125 , 126 ].…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

ESKAPE and Beyond: The Burden of Coinfections in the COVID-19 Pandemic

et al. 2023

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The ESKAPE group constitute a threat to public health, since these microorganisms are associated with severe infections in hospitals and have a direct relationship with high mortality rates. The presence of these bacteria in hospitals had a direct impact on the incidence of healthcare-associated coinfections in the SARS-CoV-2 pandemic. In recent years, these pathogens have shown resistance to multiple antibiotic families. The presence of high-risk clones within this group of bacteria contributes to the spread of resistance mechanisms worldwide. In the pandemic, these pathogens were implicated in coinfections in severely ill COVID-19 patients. The aim of this review is to describe the main microorganisms of the ESKAPE group involved in coinfections in COVID-19 patients, addressing mainly antimicrobial resistance mechanisms, epidemiology, and high-risk clones.

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COVID-19-associatedStaphylococcus aureuscavitating pneumonia

Cited by 9 publications

References 10 publications

COVID-19 and Cavitary Lesion in Lung

COVID-19 and Cavitary Lesion in Lung

Antibiotic resistance patterns of methicillin-resistant coagulase negative staphylococci isolated from blood cultures at a university hospital in Turkey

ESKAPE and Beyond: The Burden of Coinfections in the COVID-19 Pandemic

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