COVID-19-associated glomerulopathy and high-risk APOL1 genotype; Basis for a two-hit mechanism of injury? A narrative review on recent findings

Pezeshgi, Aiyoub; Mubarak, Muhammed; Djamali, Arjang; Mostafavi, Leila; Moghadam-Kia, Siamak; Alimohammadi, Niloufar; Peymani, Payam; Pezeshgi, Saharnaz

doi:10.34172/jnp.2021.11

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…Se ha descrito que los principales factores de riesgo asociados con la lesión renal aguda (LRA) son la edad avanzada, el género masculino, la gravedad de la insuficiencia respiratoria, la ventilación mecánica, la insuficiencia renal crónica preexistente, la coinfección con otros organismos y la respuesta inflamatoria sistémica [19,20]. En los pacientes afrodescendientes se ha asociado que la presencia de una variante del gen APOL1 podría actuar como un "segundo golpe" que conduce a la desregulación de los podocitos [21,22]. En nuestra institución llevamos a cabo varios estudios con relación a los desenlaces concernientes con la presencia de APOL1, 4 pacientes de esta muestra se habían estudiado para esta mutación pero ninguno era portador de alguna variante, es decir, tenían genotipo G0/G0, por lo cual no es posible hacer asociaciones en este aspecto.…”

Section: Discussionunclassified

COVID-19 in kidney transplant recipients: A experience in Colombia

Durán

Estacio

Mesa

et al. 2022

Rev. Colomb. Nefrol.

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Background: Patients with kidney transplants seem to be at particularly high risk for severe COVID19 disease due to their impaired immune responses and comorbidities. Purpose: This study aims to describe kidney transplant patients’ clinical characteristics and outcomes with SARSCOV-2 infection in a fourth-level hospital in Cali, Colombia. Methodology: We performed an observational study of kidney transplant recipients with SARS-CoV2 infection admitted at Fundación Valle del Lili from June to December 2020. To be eligible for this study, patients have symptoms compatible, a positive RT-PCR and inpatient management. Asymptomatic patients were excluded. Results: We enrolled a total of 50 patients. 64% were male, and the median age was 53.5 years (range 46-60). The comorbidities were 36 (70%) hypertension, 16 (32%) diabetes mellitus, 5 (10%) obesity. The most common immunosuppressive regimen was tacrolimus, mycophenolate and prednisone. The median time from symptoms onset to the positive RT-PCR was 7 days. The most common initial symptom was fever (64%), and fatigue (58%), cough (44%) and dyspnea (36%). Baseline levels of CRP was 6.43 mg/dL (3.25-11.22). The median lymphocyte count was 785 mm3/uL (550-1230). Baseline D-Dimer was 0.767 ug/ml (0.484-1153.5), ferritin median level was 1011ng/ml (670-2145). Six of the patients died (12%), 4/6 were by sepsis-related multi-organ failure and 2/6 were by ARDS. Conclusions: Major complications such as acute kidney injury, acute respiratory distress syndrome and mortality related to COVID-19 infection observed in our study are lower than those reported in other countries.

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Section: Discussionunclassified

COVID-19 in kidney transplant recipients: A experience in Colombia

Durán

Estacio

Mesa

et al. 2022

Rev. Colomb. Nefrol.

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“…On the other hand, these particles have adverse effects on other (Contini & Costabile, 2020) body systems, including the cardiovascular system, blood, and respiratory system in a way that they weaken the immune system and thus predispose people to COVID-19 (Contini & Costabile, 2020). Another hypothesis has been stated that the angiotensin-converting enzyme 2 facilitates the entry of these particles into the lungs, resulting in inflammation and exacerbation of COVID-19 (Comunian et al 2020;Daminov et al 2021;Elena De Angelis et al 2021a,b;Pezeshgi et al 2021). Moreover, although this hypothesis is yet to be proven, some researchers have suggested that SARS-CoV-2 may attach to PM 2.5 particles in the air, enter the lungs, and cause the disease (Laura A Rodriguez-Villamizar et al 2021a, b).…”

Section: Discussionmentioning

confidence: 99%

Correlation between environmental factors and COVID-19 indices: a global level ecological study

Mirahmadizadeh

Rezaei

Jokari

et al. 2021

Environ Sci Pollut Res

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This global level ecological study aimed to investigate the correlation between environmental factors and the COVID-19 indices. This survey is an ecological study, so all studied variables are aggregate variables. To collect the variables in the study, a data set was provided, which includes the information of each country based on the cumulative deaths, case fatality rate, recovery rate, and the number of performed COVID-19 tests. Scatter plots of environmental factors for the studied countries were drawn based on cumulative incidence rate of cases, cumulative incidence rate of death, tests, recovery rate, and case fatality rate of COVID-19. Furthermore, Spearman correlation coefficient was also used to verify the correlation between environmental factors and indicators related to COVID-19. The results of this ecological study showed that among all countries surveyed, Montenegro (60,310.56 per million) and Luxembourg (54,807.89 per million) had the highest cumulative incidence rates of COVID-19 cases, when Tanzania (8.42 per million) and Vietnam (13.78 per million) had the lowest cumulative incidence rates of COVID-19. In addition, in this study, it was shown that the cumulative incidence rate of cases, the cumulative incidence rate of deaths, and performed COVID-19 tests had significant direct correlations with the access to drinking water and the access to sanitation services (p < 0.001). The findings of the present study showed an inverse correlation between the mortality rate due to unhealthy water consumption, poor health status, and a positive correlation between access to drinking water and health services with the cumulative incidence and mortality rates of COVID-19. The differences between our findings and many other studies could be due to the ecological nature of the study. Nevertheless, our findings will help health policymakers to develop timely strategies to reduce the mortality and incidence rate of COVID-19.

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“…Coinfection with Herpesviridae causes vascular lesions (16)(17)(18)(19). In addition, it has been shown that the treatment of patients can also be associated with skin manifestation, the same as treatment with corticosteroids that can cause some symptoms, such as petechiae and purpura (16,20,21). Furthermore, the results showed that urticaria occurs mainly in adults and is seen in the trunk and face areas.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Genes and Molecular Pathways Involved in Skin Lesions in Patients with COVID-19: Systems Biology and Bioinformatics Analysis Approach

2023

ircmj

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Background: Coronavirus disease 2019 (COVID-19) was first identified in 2019 in Wuhan, China. Initially, although the number of COVID-19-infected individuals was very low, the infected cases increased as the virus spread worldwide. Skin manifestation is one of the symptoms observed in COVID-19 patients. Objectives: This study investigated the critical genes and molecular pathways involved in skin manifestations in COVID-19 patients through a biological system approach. Methods: In this study, the microarray dataset was downloaded from the Gene Expression Omnibus (GEO) database and analyzed for identifying differentially expressed genes (DEGs). The enrichment analysis of DEGs was evaluated using the DAVID database. Afterward, protein-protein interaction (PPI) networks were constructed via the STRING database and visualized using Cytoscape software. The hub genes were recognized using the cytoHubba. The interaction of the microRNA (miRNA)-hub genes, transcription factor (TF)-hub genes, and drug-hub genes was also evaluated in this study. Results: After analysis, some genes with the highest degree of connectivity, which were involved in the pathogenesis of HELLP syndrome were identified, and they were known as hub genes. These genes are as follows: IFN-γ, CXCL1, CCL2, CCL3, TLR2, IL-1B, CXCL6, IL-6, CCL4, and CXCL2. has-mir-34a-5p, has-mir-20a-5p, and has-mir-27a-3p as miRNA, as well as RELA as TF had the most interaction with the hub genes. Conclusion: Finally, IL-6 and CXCL10 that were compared to the other hub genes had the highest interaction with other genes; therefore, their role in Shamgir's pathogenesis is significant. Targeting the cited genes would be a strategy to prevent symptom manifestation and better patient management.

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COVID-19-associated glomerulopathy and high-risk APOL1 genotype; Basis for a two-hit mechanism of injury? A narrative review on recent findings

Cited by 3 publications

References 23 publications

COVID-19 in kidney transplant recipients: A experience in Colombia

COVID-19 in kidney transplant recipients: A experience in Colombia

Correlation between environmental factors and COVID-19 indices: a global level ecological study

Evaluation of the Genes and Molecular Pathways Involved in Skin Lesions in Patients with COVID-19: Systems Biology and Bioinformatics Analysis Approach

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