COVID‐19 associated coagulopathy and thromboembolic disease: Commentary on an interim expert guidance

Cannegieter, Suzanne C.; Klok, Frederikus A.

doi:10.1002/rth2.12350

Cited by 33 publications

(34 citation statements)

References 25 publications

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“… 1 Coronavirus-associated coagulopathy and thromboembolism represent one of the leading causes of death in these patients, through endothelial dysfunction and a hypercoagulable state. 2 – 5 …”

Section: To the Editormentioning

confidence: 99%

“…This validation process would be necessary because SARS-CoV-2 is not only able to interfere with the coagulation cascade in a prothrombotic way 14 , but it can also induce a sepsis-like syndrome, including disseminated intravascular coagulation, of which haemorrhage can be an outcome. 2 So, a careful evaluation of the relative risk of thrombosis and bleeding should be required in these patients.…”

Section: To the Editormentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous and severe haematomas in patients with COVID-19 on low-molecular-weight heparin for paroxysmal atrial fibrillation

Mazzitelli

Serapide

Tassone

et al. 2020

Mediterr J Hematol Infect Dis

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Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

Spontaneous and severe haematomas in patients with COVID-19 on low-molecular-weight heparin for paroxysmal atrial fibrillation

Mazzitelli

Serapide

Tassone

et al. 2020

Mediterr J Hematol Infect Dis

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“…The arrival of the novel coronavirus disease COVID-19 has caused a global pandemic affecting more than a million people [ 1 , 2 ] . While the symptomatology of the disease varies greatly between individuals, it can cause critical illness and severe respiratory failure [ 3 ] .…”

Section: Introductionmentioning

confidence: 99%

“…The variety of complications associated with this novel pathogen are being recognised. One such complication is an increased risk of thrombotic and thromboembolic disease in patients with severe COVID-19 infection [ 1 – 7 ] , even those who are anticoagulated [ 3 ] . The high incidence of thrombotic complications seen in COVID-19 infection is thought to be due to the direct effect of the pathogen on the coagulation system [ 1 , 3 – 6 ] , and indirectly via mechanisms such as critical illness, severe inflammatory response and immobility [ 3 – 6 ] .…”

Section: Introductionmentioning

confidence: 99%

A Peculiar Case of Priapism: The Hypercoagulable State in Patients with Severe COVID-19 Infection

Lam

McCarthy

Haider

2020

European Journal of Case Reports in Internal Medicine

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It is increasingly recognised that patients with severe COVID-19 infection have a significant risk of thromboembolic events. We describe a patient who rapidly deteriorated due to severe infection with COVID-19, and developed priapism in the last days of his life. We believe development of priapism may be associated with a prothrombotic state secondary to COVID-19 infection. This case report supports the widely reported increased incidence of thrombosis in patients with severe COVID-19 infection.

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“…4 People with COVID-19 can present with mild symptoms, which may progress to severe disease and affect multiple organs beyond the lungs, including the hematological systems. [5][6][7][8][9][10] Such COVID-19-related effects can contribute to an increased risk of venous and arterial thrombosis. 11,12 Although there remains an urgent need for clinical biomarkers to predict disease severity, 13 hematological impacts including increased D-dimer, fibrinogen, von Willebrand factor, and factor VIII (FVIII) levels have been associated with the occurrence of coagulopathy in COVID-19.…”

mentioning

confidence: 99%

Coronavirus (COVID-19), Coagulation, and Exercise: Interactions That May Influence Health Outcomes

Zadow

Wundersitz

Hughes

et al. 2020

Semin Thromb Hemost

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The proinflammatory cytokine storm associated with coronavirus disease 2019 (COVID-19) negatively affects the hematological system, leading to coagulation activation and endothelial dysfunction and thereby increasing the risk of venous and arterial thrombosis. Coagulopathy has been reported as associated with mortality in people with COVID-19 and is partially reflected by enhanced D-dimer levels. Poor vascular health, which is associated with the cardiometabolic health conditions frequently reported in people with severer forms of COVID-19, might exacerbate the risk of coagulopathy and mortality. Sedentary lifestyles might also contribute to the development of coagulopathy, and physical activity participation has been inherently lowered due to at-home regulations established to slow the spread of this highly infectious disease. It is possible that COVID-19, coagulation, and reduced physical activity may contribute to generate a “perfect storm,” where each fuels the other and potentially increases mortality risk. Several pharmaceutical agents are being explored to treat COVID-19, but potential negative consequences are associated with their use. Exercise is known to mitigate many of the identified side effects from the pharmaceutical agents being trialled but has not yet been considered as part of management for COVID-19. From the limited available evidence in people with cardiometabolic health conditions, low- to moderate-intensity exercise might have the potential to positively influence biochemical markers of coagulopathy, whereas high-intensity exercise is likely to increase thrombotic risk. Therefore, low- to moderate-intensity exercise could be an adjuvant therapy for people with mild-to-moderate COVID-19 and reduce the risk of developing severe symptoms of illness that are associated with enhanced mortality.

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COVID‐19 associated coagulopathy and thromboembolic disease: Commentary on an interim expert guidance

Cited by 33 publications

References 25 publications

Spontaneous and severe haematomas in patients with COVID-19 on low-molecular-weight heparin for paroxysmal atrial fibrillation

Spontaneous and severe haematomas in patients with COVID-19 on low-molecular-weight heparin for paroxysmal atrial fibrillation

A Peculiar Case of Priapism: The Hypercoagulable State in Patients with Severe COVID-19 Infection

Coronavirus (COVID-19), Coagulation, and Exercise: Interactions That May Influence Health Outcomes

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