COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature

Samaddar, Arghadip; Diwakar, Jyoti; Krishnan, Pramod; Kumari, H B Veena; Kavya, M; Konar, Subhas; Sharma, Dinesh; Nandeesh, B N; Goyal, Aditi; Nagarathna, S

doi:10.1016/j.mmcr.2021.12.002

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The mortality rate was 77.7% [90]. T. dohaense caused brain abscess associated with COVID-19, a rare infection not previously described, in the central nervous system of a diabetic patient aged 55 years [93].…”

Section: Trichosporon Sppmentioning

confidence: 81%

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Clinical Challenges of Emerging and Re-Emerging Yeast Infections in the Context of the COVID-19 Pandemic

et al. 2022

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During the geological eras, some fungi, through adaptation and/or environmental/ecological pressure, interacted directly and indirectly with humans, through occasionally harmful interaction interdependent on the individual’s immunological condition. Infections caused by yeasts are underreported, subjugated, and underdiagnosed, and treatment is restricted to a few drugs, even after the significant progress of medicine and pharmacology. In the last centuries, antagonistically, there has been an exponential increase of immunocompromised individuals due to the use of immunosuppressive drugs such as corticosteroids, increased cases of transplants, chemotherapeutics, autoimmune diseases, neoplasms, and, more recently, coronavirus disease 2019 (COVID-19). This review aims to survey emerging and re-emerging yeast infections in the current clinical context. Currently, there is an immense clinical challenge for the rapid and correct diagnosis and treatment of systemic mycoses caused by yeasts due to the terrible increase in cases in the current context of COVID-19.

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Section: Trichosporon Sppmentioning

confidence: 81%

“…show high MICs for AmB (1µg/mL), T. dohaense consistently demonstrated low MICs. Among the more recent triazoles, voriconazole (0.125 1µg/mL) and posaconazole (0.25 1µg/mL) exhibit potent in vitro activity against T. dohaense [93,94]. Invasive trichosporonosis carries a high mortality rate (40-60%) despite antifungal therapy [95].…”

Section: Trichosporon Sppmentioning

confidence: 99%

Clinical Challenges of Emerging and Re-Emerging Yeast Infections in the Context of the COVID-19 Pandemic

et al. 2022

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“…A few studies have reported invasive cerebral infections with unusual organisms in patients with COVID-19 (Table 1 ). Two studies reported fungal brain abscesses associated with trichosporonosis and phaeohyphomycosis, both in patients with diabetes[ 22 , 23 ]. This suggests that COVID-19 infection can predispose patients to unusual infections with unusual pathogens.…”

Section: Discussionmentioning

confidence: 99%

“…[ 22 ] 2022 Female 73 Hypertension, DM Fonsecaea Death Samaddar et al. [ 23 ] 2022 Male 55 Hypertension, DM Trichosporon dohaense Recovery Gupta et al. [ 32 ] 2021 Male 62 DM Aspergillus fumigatus Recovery De Villiers De La Noue et al.…”

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 (COVID-19)-associated brain abscesses caused by Pseudomonas aeruginosa and Aspergillus fumigatus: two case and a review of the literature

Yassin,

Farid,

Ahmadi

et al. 2023

J Med Case Reports

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Background Bacterial and fungal superinfections are commonly reported in patients with coronavirus disease 2019. Case presentation We report the first case of brain and intramedullary abscesses caused by Pseudomonas aeruginosa and a rare case of brain abscesses caused by Aspergillus fumigatus in two post-coronavirus disease 2019 patients. The first patient—34-year-old Iranian woman—presented with weakness of the left upper limb, headaches, and lower limb paresthesia. She had a history of undiagnosed diabetes and had received corticosteroid therapy. The second patient—45-year-old Iranian man—presented with right-sided weakness and had a history of intensive care unit admission. Both patients passed away despite appropriate medical therapy. Conclusion The immune dysregulation induced by coronavirus disease 2019 and its’ treatments can predispose patients, especially immunosuppressed ones, to bacterial and fungal infections with unusual and opportunistic pathogens in the central nervous system. Pseudomonas aeruginosa and Aspergillus fumigatus should be considered as potential causes of brain infection in any coronavirus disease 2019 patient presenting with neurological symptoms and evidence of brain abscess in imaging, regardless of sinonasal involvement. These patients should get started on appropriate antimicrobial therapy as soon as possible, as any delay in diagnosis or treatment can be associated with adverse outcomes.

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“…Almeida-Jr. [51], described 5 critical patients with COVID-19 who developed fungemia by T. asahii, who presented risk conditions: central venous catheter, previous exposure to broad-spectrum antibiotics, previous therapy with echinocandin and previous prolonged corticosteroid therapy. More currently, Cronyn [52] reported urinary infection in a male patient with severe COVID-19, isolating the co-infection agent T. asahii, treated with fluconazole and voriconazole, and finally, a case of associated brain abscess to Coronavirus Disease 2019 caused by a rare species of basidiomycete of the genus Trichosporon, T. dohaense affecting a diabetic patient who received systemic corticosteroids for the treatment of COVID-19 [53].…”

Section: Reports Of Immunosuppression In Cases Of Sars-covmentioning

confidence: 99%

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

Mariscal¹,

Matias²,

Almeida³

et al. 2023

AiM

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Background: COVID-19 is a rapidly transmissible pneumonia-like illness caused by SARS-CoV-2 that out broke in China in 2019 and is currently circulating worldwide. In the current context of the SARS-CoV-2 pandemic, complications are observed in clinical settings for the treatment of severe COVID-19 disease in nosocomial settings, due to cases of fungal co-infections. Objective: To carry out a review on fungal infections associated with respiratory infections caused by COVID-19 (Sars-Cov-2) and their aggravation. Methodology: The purpose of this study is to inform the reader about the characteristics of SARS-CoV-2 and the main fungal species that are affecting patients undergoing treatment for severe COVID-19, provoking discussion of the importance of the proposed topic, in relation to co-infections by different fungal microorganisms. Result: 80 scientific studies were selected, resulting from patients with COVID-19 and most commonly observed in patients with a history of comorbidities such as diabetes mellitus, hypertension, kidney disease, severe liver disease, oncological diseases, obesity and with severe COVID-19. These data do not represent the total number of records of the disease in the world, but cases reported by researchers in their series, showing the overlapping of fungal co-infection through the compromised immune status due to the use of therapeutic drugs, dysregulation of the microbiota, How to cite this paper: Mariscal, A.

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COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature

Cited by 6 publications

References 20 publications

Clinical Challenges of Emerging and Re-Emerging Yeast Infections in the Context of the COVID-19 Pandemic

Clinical Challenges of Emerging and Re-Emerging Yeast Infections in the Context of the COVID-19 Pandemic

Coronavirus disease 2019 (COVID-19)-associated brain abscesses caused by Pseudomonas aeruginosa and Aspergillus fumigatus: two case and a review of the literature

Challenges of the Global COVID-19 Pandemic and Invasive Fungal Pathogens in SARS-COV-2 Associations: A Dangerous Relationship

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