COVID-19 Associated Acute Necrotizing Encephalopathy Presenting as Parkinsonism and Myorhythmia

Ong, Tien Lee; Nor, Khariah Mat; Yusoff, Yusniza; Sapuan, Sapiah

doi:10.14802/jmd.21063

Cited by 14 publications

(14 citation statements)

References 7 publications

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“…The idea of the COVID-19 pandemic unmasking parkinsonism cases in the near or distant future due to the widespread of the virus globally has recently become a source of speculations and concern to many researchers (Beauchamp et al 2020;Brundin et al 2020). Up to now, 20 cases of de novo parkinsonism, presenting during or shortly after a SARS-CoV-2 infection, have been described in the literature (Faber et al 2020;Méndez-Guerrero et al 2020;Cohen et al 2020;Pilotto et al 2021;Akilli and Yosunkaya 2021;Makhoul and Jankovic 2021;Roy et al 2021;Tiraboschi et al 2021;Rass et al 2021;Ghosh et al 2021b;Ayele et al 2021;Morassi et al 2021;Cavallieri et al 2021;Ong et al 2022;Rao et al 2022). None of these patients had a family history of PD (see Table 2).…”

Section: Covid-19 Parkinsonism and Parkinson's Disease: Present And F...mentioning

confidence: 99%

Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Leta,

Urso,

Batzu

et al. 2022

J Neural Transm

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Parkinsonism secondary to viral infections is not an uncommon occurrence and has been brought under the spotlight with the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A variety of viruses have been described with a potential of inducing or contributing to the occurrence of parkinsonism and Parkinson’s disease (PD), although the relationship between the two remains a matter of debate originating with the description of encephalitis lethargica in the aftermath of the Spanish flu in 1918. While some viral infections have been linked to an increased risk for the development of PD, others seem to have a causal link with the occurrence of parkinsonism. Here, we review the currently available evidence on viral-induced parkinsonism with a focus on potential pathophysiological mechanisms and clinical features. We also review the evidence on viral infections as a risk factor for developing PD and the link between SARS-CoV-2 and parkinsonism, which might have important implications for future research and treatments.

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Section: Covid-19 Parkinsonism and Parkinson's Disease: Present And F...mentioning

confidence: 99%

Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Leta,

Urso,

Batzu

et al. 2022

J Neural Transm

View full text Add to dashboard Cite

show abstract

“…Up to now, 20 cases have been reported in the literature with new-onset symptoms of parkinsonism (bradykinesia and/or rigidity), manifesting during or shortly after a diagnosis of Covid-19 ( Table 3 ) ( Akilli & Yosunkaya, 2021 ; Ayele et al, 2021 ; Cavallieri et al, 2021 ; Cohen et al, 2020 ; Faber et al, 2020 ; Fearon et al, 2021 ; Ghosh et al, 2021 ; Makhoul & Jankovic, 2021 ; Méndez-Guerrero et al, 2020 ; Morassi et al, 2021 ; Ong et al, 2022 ; Pilotto et al, 2021 ; Rao et al, 2022 ; Rass et al, 2021 ; Roy et al, 2021 ; Tiraboschi et al, 2021 ). Only one of these patients (patient 6) had mentioned prior symptoms of prodromal PD (constipation), while none of the above cases had a family history of PD.…”

Section: Post-covid-19 Cases Of Parkinsonismmentioning

confidence: 99%

“… DaTscan: ↓ DA uptake of both putamina #16 ( Cavallieri et al, 2021 ) Unremarkable findings. DaTscan: ↓ DA uptake of both putamina #17 ( Ong et al, 2022 ) ↑ T2 signal of both thalami with hemosiderin deposition and patchy enhancement and ↑ T2 signal of the pons attributed to ANEC. #18 ( Rao et al, 2022 ) #19 ( Rao et al, 2022 ) Unremarkable findings.…”

Section: Post-covid-19 Cases Of Parkinsonismmentioning

confidence: 99%

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Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism

Leta

Boura

Wamelen

et al. 2022

International Review of Neurobiology

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“…Ghosh et al described a case of parkinsonism following osmotic demyelination syndrome in the course of SARS-CoV-2 infection in an elderly diabetic woman [ 17 ]. Tien Lee Ong et al published an interesting case report of the COVID-19 associated acute necrotizing encephalopathy manifesting as parkinsonism with myorhythmia [ 18 ].…”

Section: The Neurotropic Potential Of Sars-cov-2 and Its Possible Rol...mentioning

confidence: 99%

Parkinson’s Disease in Light of the COVID-19 Pandemic

et al. 2022

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In this review we attempt to collate the existing scientific evidence regarding the possible role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathophysiology of Parkinson’s disease (PD), as well as to investigate the impact of PD/parkinsonism on the clinical course of the viral infection itself. Since etiology of PD is not completely understood, various studies suggest different potential links between coronavirus disease 2019 (COVID-19) and PD. Suggested connections include, among others, similar prodromal symptoms, renin–angiotensin–aldosterone system involvement, or gut microbiome dysbiosis participation. Despite the initial assumptions that, as a mainly elderly population suffering from rigidity of respiratory muscles, impairment of cough reflex, and dyspnea, PD patients would be more susceptible to viral infection, and would experience a more aggressive course of COVID-19, the published scientific reports contain mutually exclusive data that require further investigation and meta-analysis.

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COVID-19 Associated Acute Necrotizing Encephalopathy Presenting as Parkinsonism and Myorhythmia

Cited by 14 publications

References 7 publications

Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Viruses, parkinsonism and Parkinson’s disease: the past, present and future

Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism

Parkinson’s Disease in Light of the COVID-19 Pandemic

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