COVID-19 Antibody in Thai Community Hospitals

Nopsopon, Tanawin; Pongpirul, Krit; Chotirosniramit, Korn; Hiransuthikul, Narin

doi:10.1101/2020.06.24.20139188

Cited by 11 publications

(13 citation statements)

References 4 publications

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“…Indeed, it was suggested that SARS-CoV-2 affected women less compared with men, due to different innate immunity, steroid hormones, and factors related to sex chromosomes ( 14 ). However, this female over male trend in asymptomatic carriers was not captured in other areas and countries, such as South Korea, Thailand, Iran, Spain, and California of USA ( 15 , 16 , 17 , 18 ). Whether this trend is observed only in Wuhan or can be observed in other parts of China or other countries too needs further investigation.…”

Section: Discussionmentioning

confidence: 90%

Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign

Pan

Yang

et al. 2021

Clinical Microbiology and Infection

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Objectives The outbreak of 2019 coronavirus disease (COVID-19) pandemic in Wuhan, China, has subsided after a hard hit by the disease and subsequent city lockdown. Information on the number of people involved in Wuhan is still inadequate. This study aimed to describe the screening results of 61,437 community members in Wuchang District, Wuhan. Methods In mid-May 2020, Wuhan launched a population-scale city-wide SARS-CoV-2 testing campaign, which aimed to perform nucleic acid and viral antibody testing for citizens in Wuhan. Here we show the screening results of cluster sampled 61,437 residents in Wuchang District, Wuhan, China. Results A total of 1470 (2.39%, 95% CI: 2.27-2.52) individuals were detected positive for at least one antiviral antibody. Among the positive individuals, 324 (0.53%, 95% CI: 0.47-0.59) and 1200 (1.95%, 95% CI: 1.85-2.07) were positive for immunoglobulin IgM and IgG, respectively, and 54 (0.08%, 95% CI: 0.07-0.12) were positive for both antibodies. The positive rate of female carriers of antibodies were higher than those of male counterparts (male-to-female ratio of 0.75), especially in elderly citizens (ratio of 0.18 in 90+ age subgroup), indicating a sexual discrepancy in seroprevalence. In addition, viral nucleic acid detection using real-time PCR had showed 8 (0.013%, 95% CI: 0.006-0.026) asymptomatic virus carriers. Conclusions The seroprevalence of SARS-CoV-2 in Wuhan was low. Most of Wuhan residents are still susceptible to this virus. Precautions, such as wearing mask, frequent hand hygiene, and proper social distance, are necessary before an effective vaccine or antiviral treatments are available.

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Section: Discussionmentioning

confidence: 90%

Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign

Pan

Yang

et al. 2021

Clinical Microbiology and Infection

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“…Moreover, intra-regional variations of seroprevalence were observed in healthcare workers, for example, seroprevalence among hospital staff in China range from 1.8% [ 5 ] to 17.1% [ 12 ] whereas seroprevalence of healthcare workers in Asia besides China and Southeast Asia ranged from 0.4% [ 13 ] to 9.1% [ 14 ]. In Southeast Asia, there were only two studies on the seroprevalence of COVID-19 in healthcare workers: one from Thailand reported a 3.7% seroprevalence [ 15 ], and one from Vietnam reported a zero seroprevalence [ 16 ]. Seroprevalences in healthcare personnel varied from 1.3% [ 17 ] to 45.3% [ 11 ] in Europe, from 0.8% [ 18 ] to 44.0% [ 19 ] in North America, from 0.9% [ 20 ] to 14.1% [ 21 ] in South America, and from zero [ 10 ] to 45.1% [ 22 ] in Africa whereas no seroprevalence studies were from Antarctica or Australia.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hospital staff in a province with zero COVID-19 cases

et al. 2021

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Background COVID-19 seroprevalence data, particularly in less developed countries with a relatively low incidence, has been scant. We aimed to explore the seroprevalence of hospital staff in the area with zero confirmed COVID-19 case to shed light on the situation of COVID-19 infection in zero or low infection rate countries where mass screening was not readily available. Methods A locally developed rapid immunoglobulin M (IgM)/immunoglobulin G (IgG) test kit was used for hospital staff screening of Ranong hospital which is located in a province with zero COVID-19 prevalence in Thailand from 17th April to 17th May 2020. All staff was tested, 100 of which were randomly invited to have a repeating antibody test in one month. (Thai Clinical Trials Registry: TCTR20200426002) Results Of 844 hospital staff, 82 were tested twice one month apart (response rate for repeating antibody test 82%). Overall, 0.8% of the participants (7 of 844) had positive IgM, none had positive IgG. Female staff had 1.0% positive IgM (95% CI: 0.5–2.1%) while male had 0.5% positive IgM (95% CI: 0.1–2.6%). No participants with a history of travel to the high-risk area or close contact with PCR-confirmed COVID-19 case developed SARS-CoV-2 antibodies. Among 844 staff, 811 had no symptoms and six of them developed IgM seropositive (0.7%) while 33 had minor symptoms and only one of them developed IgM seropositive (3.0%). No association between SARS-CoV-2 IgM status and gender, history of travel to a high-risk area, close contact with PCR-confirmed or suspected COVID-19 case, presence of symptoms within 14 days, or previous PCR status was found. None of the hospital staff developed SARS-CoV-2 IgG. Conclusions COVID-19 antibody test could detect a considerable number of hospital staff who could be potential silent spreaders in a province with zero COVID-19 cases. Accurate antibody testing is a valuable screening tool, particularly in asymptomatic healthcare workers. Trial registration: This study was approved by the Institutional Review Board of Chulalongkorn University (IRB No.236/63) and the Institutional Review Board of Ranong Hospital. (Thai Clinical Trials Registry: TCTR20200426002).

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“…In China, for example, seroprevalence among hospital staff ranged from 1.8% (4) to 17.1% (9) whereas seroprevalence of healthcare workers in Asia besides China ranged from 3.3% (10) to 5.4% (11). In Southeast Asia, there was only a study from Thailand reported a 3.7% seroprevalence (12). Seroprevalences in healthcare personnel varied from 1.1% (13) to 45.3% in Europe (8) and from 2% (3) to 7.6% (14) in North America.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hospital Staff in Province with Zero COVID-19 Cases

Nopsopon

Pongpirul

Chotirosniramit

et al. 2020

Preprint

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BACKGROUND. COVID-19 seroprevalence data has been scarce, especially in less developed countries with a relatively low infection rate. METHODS. A locally developed rapid IgM/IgG test kit was used for screening hospital staff in Ranong hospital which located in a province with zero COVID-19 prevalence in Thailand from April 17 to May 17, 2020. A total of 844 participants were tested; 82 of which were tested twice with one month apart. (Thai Clinical Trials Registry: TCTR20200426002) RESULTS. Overall, 0.8% of the participants (7 of 844) had positive immunoglobulin M (IgM), none had positive immunoglobulin G (IgG). Female staffs seemed to have higher IgM seropositive than male staffs (1.0% vs. 0.5%). None of the participants with a history of travel to the high-risk area or a history of close contact with PCR-confirmed COVID-19 case had developed antibodies against SARS-CoV-2. Among 844 staff, 811 had no symptom and six of them developed IgM seropositive (0.7%) while 33 had minor symptoms and only one of them developed IgM seropositive (3.0%). No association between IgM antibody against SARS-CoV-2 status and gender, history of travel to a high-risk area, history of close contact with PCR-confirmed COVID-19 case, history of close contact with suspected COVID-19 case, presence of symptoms within 14 days, or previous PCR status was found. None of the hospital staff developed IgG against SARS-CoV-2. CONCLUSION. COVID-19 antibody test could detect a substantial number of hospital staffs who could be potential silent spreaders in a province with zero COVID-19 case. Antibody testing should be encouraged for mass screening, especially in asymptomatic healthcare workers.

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COVID-19 Antibody in Thai Community Hospitals

Cited by 11 publications

References 4 publications

Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign

Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign

Seroprevalence of hospital staff in a province with zero COVID-19 cases

Seroprevalence of Hospital Staff in Province with Zero COVID-19 Cases

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