COVID-19 and vaccination against SARS-CoV-2 in patients with neuromyelitis optica spectrum disorders

Risk of disease relapse following COVID-19 vaccination in patients with AQP4-IgG-positive NMOSD and MOGAD

“…Similarly, no attacks were reported among 9 NMOSD patients that received the Beijing/Sinopharm-BBIBP-CorV (n=8) or BNT162b2-Pfizer-BioNTech vaccines (n=1) ( Jovicevic et al, 2021 ). These data are in line with our findings, although we observed a higher frequency of minor side effects, particularly pain at vaccine injection site ( Lotan et al, 2021 , Jovicevic et al, 2021 ).…”

“…In a large web-based study on SARS-CoV-2 vaccination in patients with neuroimmunological disorders, including MOGAD and AQP4-IgG+NMOSD, no post-vaccination relapses were detected, although 17.8% of patients reported new or worsening of previous symptoms requiring in some cases specific treatment (Lotan et al, 2021). Of note, distinction of relapses vs pseudo-relapses is mandatory and often challenging, since infection or vaccination side effects (as fever) can per se cause transient worsening of Similarly, no attacks were reported among 9 NMOSD patients that received the Beijing/Sinopharm-BBIBP-CorV (n = 8) or BNT162b2-Pfizer-BioNTech vaccines (n = 1) (Jovicevic et al, 2021). These data are in line with our findings, although we observed a higher frequency of minor side effects, particularly pain at vaccine injection site (Lotan et al, 2021;Jovicevic et al, 2021).…”

“…Of note, distinction of relapses vs pseudo-relapses is mandatory and often challenging, since infection or vaccination side effects (as fever) can per se cause transient worsening of Similarly, no attacks were reported among 9 NMOSD patients that received the Beijing/Sinopharm-BBIBP-CorV (n = 8) or BNT162b2-Pfizer-BioNTech vaccines (n = 1) (Jovicevic et al, 2021). These data are in line with our findings, although we observed a higher frequency of minor side effects, particularly pain at vaccine injection site (Lotan et al, 2021;Jovicevic et al, 2021).…”

Humoral response to SARS-CoV-2 infection and vaccines against COVID-19 in patients with neuromyelitis optica spectrum disorders: Impact of immunosuppressive treatment

“…Demographic and clinical characteristics were extracted from the Hospital registry. Data related to the diagnosis of the COVID-19 infection and vaccination against SARS-CoV-2 in our patients has been already described ( Jovicevic et al, 2022 ).…”

“…Fifty three NMOSD patients who accepted to participate in our previous study ( Jovicevic et al, 2022 ) were contacted by phone, between April 10, 2021 and September 6, 2021, in order to obtain current information regarding COVID-19 and vaccination against SARS-CoV-2. Out of this cohort, 15 patients had COVID-19 and 9 were vaccinated.…”