COVID-19 and the Kidney: Recent Advances and Controversies

Menez, Steven; Parikh, Chirag R.

doi:10.1016/j.semnephrol.2022.10.005

Cited by 6 publications

(7 citation statements)

References 57 publications

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“…First, the single-cell characterization of AKI in our patients might include some COVID19-specific findings. 25 The atlas of transcriptionally defined cell states should be expanded to include different types of kidney injury and to correctly address the multidimensional complexity of human diseases and possible confounders, such as comorbidities and medication. Moreover, we used the single-cell signatures as reported by the authors of the corresponding publications.…”

Section: Discussionmentioning

confidence: 99%

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

Legouis,

Rinaldi,

Malpetti

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

Legouis,

Rinaldi,

Malpetti

et al. 2024

iScience

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“…In addition, it was observed that patients of severe, and critical groups had values of GLU-U and PRO higher than patients of the moderate group. These results indicate that biochemical urine parameters are useful to show AKI in the advanced stages of the disease and could have a predictive role in disease severity [ 3 , 4 , 5 , 7 , 8 , 10 , 14 , 16 ]. The studies presented by Yildirim, C. et al [ 9 ] and Bassoli, C et al [ 11 ] evaluated PRO as an early predictor of COVID-19-related renal damage [ 9 , 11 ].…”

Section: Methods: Identification and Characteristics Of Included Studiesmentioning

confidence: 99%

“…An interesting example is urinalysis, which can give an idea of the involvement of the kidneys in the disease. In fact, the involvement of the kidney in COVID-19 infection is reported since the virus can affect the glomeruli, tubules, or renal interstitium and can lead to acute kidney injury (AKI) [ 3 , 4 , 5 ]. Thus, urinary microscopy is an essential part of urinalysis that could be considered a valuable prognostic and diagnostic tool.…”

Section: Introductionmentioning

confidence: 99%

Urine Parameters in Patients with COVID-19 Infection

Morello,

Amoroso,

Losacco

et al. 2023

Life

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A urine test permits the measure of several urinary markers. This is a non-invasive method for early monitoring of potential kidney damage. In COVID-19 patients, alterations of urinary markers were observed. This review aims to evaluate the utility of urinalysis in predicting the severity of COVID-19. A total of 68 articles obtained from PubMed studies reported that (i) the severity of disease was related to haematuria and proteinuria and that (ii) typical alterations of the urinary sediment were noticed in COVID-19-associated AKI patients. This review emphasizes that urinalysis and microscopic examination support clinicians in diagnosing and predicting COVID-19 severity.

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“…AKI is a common complication of COVID-19, while CKD is a high-risk factor for COVID-19 and its related mortality [ 124 ]. Transcriptome analysis has identified common pathways and molecular biomarkers for COVID-19, AKI, and CKD [ 125 ].…”

Section: Controversiesmentioning

confidence: 99%

Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147

Habeichi,

Amin,

Lakkis

et al. 2024

Front. Biosci. (Landmark Ed)

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Kidney damage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur even in patients with no underlying kidney disease. Signs of kidney problems can progress to a state that demands dialysis and hampering recovery. Although not without controversy, emerging evidence implicates direct infectivity of SARS-CoV-2 in the kidney. At the early stage of the pandemic, consideration was mainly on the well-recognized angiotensin-converting enzyme 2 (ACE2) receptor as being the site for viral interaction and subsequent cellular internalization. Despite the abundance of ACE2 receptors in the kidneys, researchers have expanded beyond ACE2 and identified novel viral entry pathways that could be advantageously explored as therapeutic targets. This review presents the potential involvement of toll-like receptor 4 (TLR-4), kidney injury molecule-1/T cell immunoglobulin mucin domain 1 (KIM-1/TIM-1), and cluster of differentiation 147 (CD147) in SARS-CoV-2-associated renal damage. In this context, we address the unresolved issues surrounding SARS-CoV-2 renal infectivity.

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COVID-19 and the Kidney: Recent Advances and Controversies

Cited by 6 publications

References 57 publications

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

A transfer learning framework to elucidate the clinical relevance of altered proximal tubule cell states in kidney disease

Urine Parameters in Patients with COVID-19 Infection

Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147

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