COVID-19 and sudden cardiac death: A new potential risk

Yadav, Rakesh Kumar; Bansal, Ravi; Budakoty, Sudhanshu; Barwad, Parag

doi:10.1016/j.ihj.2020.10.001

Cited by 34 publications

(26 citation statements)

References 51 publications

(60 reference statements)

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“…In a study involving 191 inpatients, about 1:5 had increased cardiac enzymes and evidence of heart failure (59). Overall, the level of myocardial compromise appears to have three major determinants: (1) the presence of preexisting cardiovascular disease, for whom over 50% develop elevated cardiac enzymes and often progress to malignant arrhythmia and cardiac failure (59); (2) intensity of viral load manifesting with high troponin levels and severe viral myocarditis (60); and (3) inappropriate inflammatory response resulting in acute respiratory distress syndrome, multi-organ failure and disseminated intravascular coagulation that share some features with macrophage activation syndrome (MAS) (61).…”

Section: Cardiovascular Involvement Of Covid-19mentioning

confidence: 99%

Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

et al. 2020

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MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.

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Section: Cardiovascular Involvement Of Covid-19mentioning

confidence: 99%

Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

et al. 2020

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“…Multiple factors play an important role in the development of SCA in patients with severe systemic illness. Factors include but are not limited to hypoxia, acidosis, dyselectrolytemia, volume imbalances, drug-drug interactions, autonomic nervous system activation, severe inflammation, ischemia, and direct viral involvement of the myocardium [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Coronary CTA for our patient showed no evidence of coronary stenosis or plaque. The patient’s coronary calcium score of 0 was consistent with a type-II myocardial infarction secondary to persistent hypoxia and consequent demand-supply mismatch, resulting in myocardial injury [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sudden cardiac death (SCD) in COVID-19 patients is an alarming concern for clinicians. The incidence of SCD has been reported to be growing both in community and hospital settings [ 1 ]. Disturbingly, a recent study analyzing the data on 141 fatal cases of confirmed COVID-19 at a hospital in Wuhan, China, found sudden cardiac arrest (SCA) (n=11, 8%) to be the third-highest direct cause of death [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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The Role of the Automated Implantable Cardioverter Defibrillator (AICD) for Secondary Prevention in the COVID-19 Era

Doodnauth¹,

Zhou²,

Patel³

et al. 2021

Cureus

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Life-threatening arrhythmias have been variably reported among patients hospitalized for COVID-19 infection. Sudden cardiac arrest (SCA) in COVID-19 patients is an alarming concern for clinicians. Multiple factors play an important role in the development of SCA in patients with severe systemic illness. We describe a case of COVID-19 in a New York City hospital in Spring 2020 that rapidly developed SCA and, before discharge, received a single lead transvenous implantable cardioverter defibrillator for secondary prevention. This case highlights the use of an automated implantable cardioverter-defibrillator as a secondary preventive measure irrespective of left ventricular function as a means of preventing recurrence of SCA as a sequela of COVID-19.

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“…Direct causal association of SCD and COVID-19 is still unproven however analysis of the present evidence suggests a plausible association beside other causes. 52 …”

Section: Covid-19 Pandemic and Cardiovascular Carementioning

confidence: 99%