COVID-19 and stroke in sub-Saharan Africa: case series from Dar es Salaam

Adebayo, Philip; Kassam, Nadeem; Aziz, Omar; Jusabani, Ahmed; Somji, Samina; Mazoko, Mugisha C

doi:10.11604/pamj.supp.2020.35.24611

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…1,[22][23][24][25] In the absence of a well-defined population-level denominator, one cannot determine the extent of infection in controls, hence the strength of association between infection and neurological disease or who is at risk of such complications. Although there are some reports published from low-and middleincome countries (LMICs), [26][27][28][29][30][31] data are scarce, which leads to underrepresentation of these patients in our understanding of the spectrum of COVID-19 complications. Furthermore, the spectrum of the disease often reflects the most severely affected cases, such as those in ICUs.…”

Section: Representativeness Of Study Populationsmentioning

confidence: 99%

Approaches to Understanding COVID‐19 and its Neurological Associations

Beghi

Michael

Solomon

et al. 2021

Annals of Neurology

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There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID‐19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore, a global COVID‐19 Neuro Research Coalition, together with the World Health Organization, has reviewed reports of COVID‐19 neurological complications and harmonized clinical measures for future research. This will facilitate well‐designed studies using precise, consistent case definitions of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and neurological complications, with standardized forms for pooled data analyses that nonspecialists can use, including those in low‐income settings. ANN NEUROL 2021;89:1059–1067

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Section: Representativeness Of Study Populationsmentioning

confidence: 99%

Approaches to Understanding COVID‐19 and its Neurological Associations

Beghi

Michael

Solomon

et al. 2021

Annals of Neurology

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“…In Northern Africa, neurological manifestations of COVID-19 have been reported in several hospital-based cross-sectional studies [ 13 - 15 ]. On the contrary, apart from a few case reports [ 16 - 18 ], data on the neurological manifestations of COVID-19 in sub-Saharan Africa are scarce. This study aimed to determine the frequency and types of neurological symptoms in patients with COVID-19 in Bafoussam, a semi-urban sub-Saharan setting.…”

Section: Introductionmentioning

confidence: 99%

Neurological manifestations in patients with symptomatic COVID-19 admitted to the Bafoussam Regional Hospital, Cameroon

Fogang¹,

Noubom²,

Bassong³

et al. 2021

Pan Afr Med J

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Introduction although the main manifestations of COVID-19 are respiratory, several neurological symptoms and complications have also been reported. The pandemic seems to have some epidemiological specificities in sub-Saharan Africa, and this may be reflected in the type and frequency of neurological symptoms. This study aimed to report neurological manifestations associated with symptomatic COVID-19 in a sub-Saharan African setting. Methods we conducted a retrospective review of symptomatic PCR-confirmed COVID-19 cases admitted to the Bafoussam Regional Hospital between March and September 2020. Patients’ files were reviewed at discharge by a consultant neurologist. Socio-demographic characteristics, co-morbidities, symptoms on admission, neurological symptoms during hospitalization, management, and in-hospital outcome were recorded. Comparisons between patients with and without neurological symptoms were performed using Fisher’s exact and Mann-Whitney U test. Results we enrolled 177 symptomatic patients (68% men). Mean age was 54.6 ± 17.8 years (range 2-99 years). Co-morbidities were present in 57.6% of patients, including hypertension (27.1%) and diabetes mellitus (25.4%). Neurological symptoms were found in 113 (63.8%) patients. The most frequent were headache (39.0%), myalgia (35.6%), anosmia (11.9%), impaired consciousness (10.7%) and delirium (5.6%). Regarding the presenting symptoms, fever was more frequent in patients with neurological symptoms than in those without (81.4% versus 50.0%, p< 0.001), while digestive symptoms were less frequent in patients with neurological symptoms (0.9% versus 9.4%, p= 0.004). Conclusion neurological manifestations are frequent and heterogeneous in patients with symptomatic COVID-19. Further studies are needed to clarify the pathophysiology of neurological symptoms in COVID-19 and their impact on patients’ long-term outcome.

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COVID-19 and stroke in sub-Saharan Africa: case series from Dar es Salaam

Cited by 2 publications

References 17 publications

Approaches to Understanding COVID‐19 and its Neurological Associations

Approaches to Understanding COVID‐19 and its Neurological Associations

Neurological manifestations in patients with symptomatic COVID-19 admitted to the Bafoussam Regional Hospital, Cameroon

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