COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial

Sahanic, Sabina; Tymoszuk, Piotr; Luger, Anna; Hüfner, Katharina; Boehm, Anna; Pizzini, Alex; Schwabl, Christoph; Koppelstätter, Sabine; Kurz, Katharina; Aßhoff, Malte; Mosheimer-Feistritzer, Birgit; Coen, Maximilian; Pfeifer, Bernhard; Rass, Verena; Egger, Alexander; Hörmann, Georg; Sperner‐Unterweger, Barbara; Helbok, Raimund; Wöll, Ewald; Weiss, Günter; Widmann, Gerlig; Tancevski, Ivan; Sonnweber, Thomas; Löffler‐Ragg, Judith

doi:10.1183/23120541.00317-2022

Cited by 15 publications

(15 citation statements)

References 47 publications

(62 reference statements)

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“…A total of 2517 studies were identified, of which 43 met the inclusion (N = 8858 patients) ( Figure 1 ) [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ]. The majority of studies were from China (14 studies [ 51 , 58 , 59 , 60 , 61 , 64 , 65 , …”

Section: Resultsmentioning

confidence: 99%

Short- and Long-Term Chest-CT Findings after Recovery from COVID-19: A Systematic Review and Meta-Analysis

Babar,

Jamil,

Mehta

et al. 2024

Diagnostics

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While ground-glass opacity, consolidation, and fibrosis in the lungs are some of the hallmarks of acute SAR-CoV-2 infection, it remains unclear whether these pulmonary radiological findings would resolve after acute symptoms have subsided. We conducted a systematic review and meta-analysis to evaluate chest computed tomography (CT) abnormalities stratified by COVID-19 disease severity and multiple timepoints post-infection. PubMed/MEDLINE was searched for relevant articles until 23 May 2023. Studies with COVID-19-recovered patients and follow-up chest CT at least 12 months post-infection were included. CT findings were evaluated at short-term (1–6 months) and long-term (12–24 months) follow-ups and by disease severity (severe and non-severe). A generalized linear mixed-effects model with random effects was used to estimate event rates for CT findings. A total of 2517 studies were identified, of which 43 met the inclusion (N = 8858 patients). Fibrotic-like changes had the highest event rate at short-term (0.44 [0.3–0.59]) and long-term (0.38 [0.23–0.56]) follow-ups. A meta-regression showed that over time the event rates decreased for any abnormality (β = −0.137, p = 0.002), ground-glass opacities (β = −0.169, p < 0.001), increased for honeycombing (β = 0.075, p = 0.03), and did not change for fibrotic-like changes, bronchiectasis, reticulation, and interlobular septal thickening (p > 0.05 for all). The severe subgroup had significantly higher rates of any abnormalities (p < 0.001), bronchiectasis (p = 0.02), fibrotic-like changes (p = 0.03), and reticulation (p < 0.001) at long-term follow-ups when compared to the non-severe subgroup. In conclusion, significant CT abnormalities remained up to 2 years post-COVID-19, especially in patients with severe disease. Long-lasting pulmonary abnormalities post-SARS-CoV-2 infection signal a future public health concern, necessitating extended monitoring, rehabilitation, survivor support, vaccination, and ongoing research for targeted therapies.

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Section: Resultsmentioning

confidence: 99%

Short- and Long-Term Chest-CT Findings after Recovery from COVID-19: A Systematic Review and Meta-Analysis

Babar,

Jamil,

Mehta

et al. 2024

Diagnostics

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“…Approximately 1 year after infection, different studies report frequencies ranging from 40% to as high as 65%. 3,5,16 According to Van Wambeke et al, 90% of post-COVID patients reported fatigue as a lingering symptom at the 15-month mark following infection. 15 Furthermore, according to a recent meta-analysis, 52.6% of hospitalized patients had at least one symptom after 126 days, with fatigue, pain or discomfort, sleep disturbances, dyspnea and restricted usual activity being the five most common symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…27 One of the most often impacted elements is mental health. 16 Regardless of disease severity and despite the fact that most COVID-19 survivors resume their old way of life, they exhibit a markedly worse QoL and health status. 5 Regarding vaccination status, we did not find any substantial correlation between vaccinated or unvaccinated patients or the number of doses received with the persistence of symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Long-term outcomes, residual symptoms and quality of life in COVID-19 hospitalized patients: A 12-month longitudinal study

Manta,

Michelakis,

Dafni

et al. 2023

Journal of Investigative Medicine

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The long-term impact of the COVID-19 pandemic is a critical public health concern. The presence of residual symptoms in COVID-19 survivors has been investigated with various results; however, there is limited data documenting outcomes longer than 6 months post hospitalization. We aimed to investigate the 12-month lasting effects of COVID-19 in hospitalized patients. From October 2020 through March 2021, 92 patients were enrolled. At admission and 1, 3, 6, and 12 months post hospitalization, demographic, clinical, laboratory and imaging data, and echocardiography and spirometry test results were recorded. Possible cognitive and functional impairment, as well as the quality of life were also assessed. In our cohort (median age: 61 years), 31.5% had severe disease at admission, which correlated with worse laboratory findings and a longer hospital stay (p<0.001). Inflammatory markers were associated with severity initially, but reverted to normal after three months. In total, 55%, 37%, 19%, and 15.5% of patients reported at least one persistent symptom in months 1, 3, 6, and 12, respectively, while “brain fog” persisted up to 12 months in 10% of patients. Spirometry and echocardiography tests returned to normal in most patients during the evaluation, and no one had substantial residual disease. Our study provides insight into the long-term effects of COVID-19 on patients’ physical and mental health. Despite the lack of significant residual disease or major complications after a year of thorough follow-up, COVID-19 survivors experienced lasting symptoms and a negative impact on their quality of life.

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“…These challenges have been typically assessed through symptom checklists[5], generic measures such as the PHQ-9 and GAD-7, and generic health-related quality of life measures like the EQ-5D. [6–8]…”

Section: Introductionmentioning

confidence: 99%

Portrait of Mental Health Identified by People with the Post-Covid Syndrome

Mayo,

Hum,

Matout

et al. 2023

Preprint

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AimsThe Post-COVID-19 syndrome (PCS) represents an epidemic within the COVID-19 pandemic, with potentially serious consequences for affected individuals, the healthcare system, and society at large. Facing a new and poorly understood health condition, this study aimed to produce a patient-centered understanding of mental health symptom patterns, functional impact, and intervention priorities.MethodsA cross-sectional analysis of the first 414 participants in a longitudinal study recruited over a 5- month from September 2022 to January 2023 was carried out involving people from Quebec who self-identified as having symptoms of PCS. People were asked to name areas of their mental health affected by PCS using the structure of the Patient Generated Index (PGI), an individualized measure suited to eliciting the most frequent and most bothersome symptoms. The PGI was supplemented with a set of patient-reported outcome measures across the rubrics of the Wilson- Cleary model. The text threads from the PGI were grouped into topics using BERTopic analysis.ResultsTwenty topics were identified from 818 text threads referring to PCS mental health symptoms nominated using the PGI format. 35% of threads were identified as relating to anxiety, discussed in terms of five topics: generalized/social anxiety, fear/worry, post-traumatic stress, panic, and nervous. 29% of threads were identified as relating to low mood, represented by five topics: depression, discouragement, emotional distress, sadness, and loneliness. A cognitive domain (22% of threads) was covered by four topics referring to concentration, memory, brain fog, and mental fatigue. Topics related to frustration, anger, irritability. and mood swings (7%) were considered as one domain and there were separate topics related to motivation, insomnia, and isolation.ConclusionThis novel method of digital transformation of unstructured text data uncovered different ways in which people think about classical mental health domains. This information could be used to evaluate the extent to which existing measures cover the content identified by people with PCS or to justify the development of a new measure of the mental health impact of PCS.

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COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial

Cited by 15 publications

References 47 publications

Short- and Long-Term Chest-CT Findings after Recovery from COVID-19: A Systematic Review and Meta-Analysis

Short- and Long-Term Chest-CT Findings after Recovery from COVID-19: A Systematic Review and Meta-Analysis

Long-term outcomes, residual symptoms and quality of life in COVID-19 hospitalized patients: A 12-month longitudinal study

Portrait of Mental Health Identified by People with the Post-Covid Syndrome

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