Covid-19 and ethnicity: it’s too early to point to healthcare provider attitudes as a cause of poorer outcomes

Dimarco, Anthony

doi:10.1136/bmj.m2181

Cited by 1 publication

(1 citation statement)

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“…So far, only a limited number of studies have looked for an association between HLA haplotypes and genetic susceptibility or resistance to SARS coronavirus infection. However, an impact of HLA haplotypes may identify some of the unexplained differences in disease severity and mortality observed across different countries and different population ethnicities (150)(151)(152)(153)(154). Allele typing of 37 probable SARS patients in Taiwan identified an association between HLA-B * 4601 and SARS-CoV infection (155); however, this was not confirmed in a study of 90 serologically confirmed SARS-CoV patients in Hong Kong (156,157).…”

Section: Human Inborn Errors Of Immunity Predisposing To Coronavirus mentioning

confidence: 99%

Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19

et al. 2020

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Coronavirus disease-19 (COVID-19) describes a set of symptoms that develop following infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whilst COVID-19 disease is most serious in patients with significant co-morbidities, the reason for healthy individuals succumbing to fulminant infection is largely unexplained. In this review, we discuss the most recent findings in terms of clinical features and the host immune response, and suggest candidate immune pathways that may be compromised in otherwise healthy individuals with fulminating COVID-19. On the basis of this early knowledge we reason a potential genetic effect on host immune response pathways leading to increased susceptibility to SARS-CoV-2 infection. Understanding these pathways may help not only in unraveling disease pathogenesis, but also in suggesting targets for therapy and prophylaxis. Importantly such insight should instruct efforts to identify those at increased risk in order to institute preventative measures, such as prophylactic medication and/or vaccination, when such opportunities arise in the later phases of the current pandemic or during future similar pandemics.

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