COVID-19 and Elevated D-Dimer: A Tale of Caution

Aurón, Moisés; Aguilar, Mateo Porres; Cameron, Scott J.

doi:10.1007/s11606-021-07280-9

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Many investigations have found that among subjects infected with COVID-19, there is advancement in impaired liver functions. Along with that another recent researchers are reported that many of COVID 19 disease patients are observed abnormal liver function tests during the infection stage [ 29 - 30 ]. The pathophysiology of liver damage in COVID 19 patients, one of the main reasons is angiotensin converting enzyme II, act as a host for novel coronavirus into the liver cells, along with this inflammatory and pro-inflammatory cytokines damage the pulmonary and extra-pulmonary cells along with the liver [ 31 - 32 ].…”

Section: Discussionmentioning

confidence: 97%

Relating D-Dimer, blood sugars, haemoglobin and liver function among COVID patients with T2DM

Setty

2023

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It is of interest to evaluate the correlation of D-Dimer, blood sugars, haemoglobin and liver function tests with novel coronavirus in patients with T2DM with and without symptoms. We recruited 200 patients with T2DM and COVID 19 with and without symptoms admitted in Rajarajeshwari Medical College and Hospital, Karnataka. Blood sugars, HbA1c, D-Dimer and also the incidence of T2DM and COVID 19 with and without symptoms were evaluated in all study subjects. There was a significant increased levels of biochemical parameters in T2DM and COVID 19 with symptoms when compared to T2DM and COVID 19 without symptoms (P<0.05). The D-Dimer levels was positively correlated with CT values, (r=0.518, P<0.05). Based on the study findings, the novel coronavirus enhances the insulin resistance, hyper-glycemia, abnormality in the liver and thrombolysis. Additionally, we also suggest that the subjects with T2DM and COVID 19 with and without symptoms require continuous monitoring of D-DIMER and LFT.

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Section: Discussionmentioning

confidence: 97%

Relating D-Dimer, blood sugars, haemoglobin and liver function among COVID patients with T2DM

Setty

2023

Bioinformation

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“…8 Other studies have suggested that D-dimer is increased in most patients with COVID-19, so clinical decisions should not be based on this biomarker alone. 9 It appears that D-dimer values increase as one of many defense mechanisms against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; normally, the activation of broncho-alveolar hemostasis shifts toward fibrinolysis, thus allowing normal gas exchange and leading to elevated D-dimer in most patients during the onset of the disease. The extensive inflammation that develops in complicated COVID-19 patients leads to elevated extravascular fibrinogen levels, which do not merely indicate an increased risk of thrombosis but could actually be of use in the prediction of clinical outcomes and complications.…”

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confidence: 99%