COVID-19 and cardiovascular diseases

Mai, Francesca; Pinto, Rita Del; Ferri, Claudio

doi:10.1016/j.jjcc.2020.07.013

Cited by 58 publications

(42 citation statements)

References 49 publications

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“…AF is one of the common chronic comorbidities found in patient deaths due to COVID-19. 48 In a large propensity score matched study of COVID-19 patients aged over 50 years of age, AF significantly increased short-term mortality and thromboembolic events. 49 Risk factors for the development of cardiac arrhythmias are: 1.…”

Section: Pericarditis and Pericardial Effusionmentioning

confidence: 99%

Cardiovascular Complications of COVID-19 Infection

2021

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Introduction: Reports of cardiovascular complications related to the COVID-19 infection have been frequent.Methods: Narrative review for relevant articles on the topic. The classic cardiovascular risk factors, like age, obesity, diabetes, and hypertension are associated with adverse outcomes in COVID-19 patients. Cardiovascular complications can have a diverse clinical presentation including silent myocardial injury, acute coronary syndromes, thromboembolism, cardiac arrhythmias, and heart failure. There are multiple mechanisms of cardiac injury that are not mutually exclusive. The approach to diagnosis and management should be carried out according to usual practice, while considering the particularities of COVID-19 infection.Conclusion: The interaction between SARS-CoV-2 and the heart is complex and is manifested in multiple ways. Regardless of the clinical presentation, cardiac complications convey a worse prognosis. Patients should be actively monitored and treated accordingly.

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Section: Pericarditis and Pericardial Effusionmentioning

confidence: 99%

Cardiovascular Complications of COVID-19 Infection

2021

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“…In fact, it aggravates the disease burden by worsening the cardiac involvement and by increasing the risk of end stage renal disease (ESRD) and stroke [2]. Further, since many mechanisms can intervene in the determination of BP levels [45], hypertension might be difficult to control in Fabry disease due to the underlying proinflammatory environment, similar to what is widely observed in the presence of low-grade systemic inflammation of other sources [46][47][48][49][50].…”

Section: Cardiovascular Risk Management In Fabry Disease: Focus On Hymentioning

confidence: 99%

The role of Immunity in Fabry Disease and Hypertension: A Review of a Novel Common Pathway

Pinto

Ferri

2020

High Blood Press Cardiovasc Prev

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Fabry disease is a progressive, X-linked inherited lysosomal storage disorder where accumulation of glycosphingolipids increases the risk for early cardiovascular complications, including heart failure, stroke, and end stage renal disease. Besides disease-specific therapy, blood pressure (BP) control is of central importance in Fabry disease to reduce disease progression and improve prognosis. Both Fabry disease and hypertension are characterized by the activation of the innate component of the immune system, with Toll-like receptor 4 (TLR4) as a common trigger to the inflammatory cascade. The renin-angiotensin system (RAS) participates in the establishment of low-grade chronic inflammation and redox unbalance that contribute to organ damage in the long term. Besides exploiting the anti-inflammatory effects of RAS blockade and enzyme replacement therapy, targeted therapies acting on the immune system represent an appealing field of research in these conditions. The aim of this narrative review is to examine the issue of hypertension in the setting of Fabry disease, focusing on the possible determinants of their reciprocal relationship, as well as on the related clinical and therapeutic implications.

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“…Second, the significance of this paper is heightened due to the impact of COVID-19 on mortality rates. Both COVID-19 and heat-related mortality impact similar groups, such as the elderly and those with cardiovascular and respiratory disease [53]. Thus, the distinction between deaths attributable to heat and COVID-19 is likely to be problematic.…”

Section: Introductionmentioning

confidence: 99%

Excess Mortality in England during the 2019 Summer Heatwaves

Rustemeyer

Howells

2021

Climate

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There is increasing evidence that rising temperatures and heatwaves in the United Kingdom are associated with an increase in heat-related mortality. However, the Public Health England (PHE) Heatwave mortality monitoring reports, which use provisional death registrations to estimate heat-related mortality in England during heatwaves, have not yet been evaluated. This study aims to retrospectively quantify the impact of heatwaves on mortality during the 2019 summer period using daily death occurrences. Second, using the same method, it quantifies the heat-related mortality for the 2018 and 2017 heatwave periods. Last, it compares the results to the estimated excess deaths for the same period in the PHE Heatwave mortality monitoring reports. The number of cumulative excess deaths during the summer 2019 heatwaves were minimal (161) and were substantially lower than during the summer 2018 heatwaves (1700 deaths) and summer 2017 heatwaves (1489 deaths). All findings were at variance with the PHE Heatwave mortality monitoring reports which estimated cumulative excess deaths to be 892, 863 and 778 during the heatwave periods of 2019, 2018 and 2017, respectively. Issues are identified in the use of provisional death registrations for mortality monitoring and the reduced reliability of the Office for National Statistics (ONS) daily death occurrences database before 2019. These findings may identify more reliable ways to monitor heat mortality during heatwaves in the future.

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COVID-19 and cardiovascular diseases

Cited by 58 publications

References 49 publications

Cardiovascular Complications of COVID-19 Infection

Cardiovascular Complications of COVID-19 Infection

The role of Immunity in Fabry Disease and Hypertension: A Review of a Novel Common Pathway

Excess Mortality in England during the 2019 Summer Heatwaves

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