COVID-19 and candiduria: an investigation of the risk factors and immunological aspects

Singulani, Júnya de Lacorte; Silva, Danielle L. da; Lima, Caroline M; Magalhães, Vanessa Caroline Randi; Baltazar, Ludmila Matos; Moura, Alexandre Sampaio; Santos, Ana Raquel O.; Fereguetti, Tatiani; Martins, Juliana Carvalho; Rabelo, Lívia F; Lyon, Ana Cláudia; Martins‐Filho, Olindo Assis; Johann, Susana; Peres, Nalu T. A.; Reis, J; Santos, Danielle Anjos dos

doi:10.1007/s42770-023-01042-x

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…It is found mainly in the basement membrane and subendothelial extracellular matrix of blood vessels ( 52 ). Basic- FGF induces the expression of genes involved in inflammatory processes, including proinflammatory cytokines (mainly IL-6) and their receptors, endothelial cell adhesion molecules, and prostaglandin pathway components ( 53 ). In the current study, basic-FGF levels were higher in patients with stage 2 COVID-19 than in asymptomatic/mildly symptomatic patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study

Wolszczak-Biedrzycka,

Dorf,

Wojewódzka-Żelezniakowicz

et al. 2024

Front. Immunol.

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AimThe aim of the present study was to assess differences in the serum levels of chemokines and growth factors (GFs) between COVID-19 patients and healthy controls. The diagnostic utility of the analyzed proteins for monitoring the severity of the SARS-CoV- 2 infection based on the patients’ MEWS scores was also assessed.Materials and methodsThe serum levels of chemokines and growth factors were analyzed in hospitalized COVID-19 patients (50 women, 50 men) with the use of the Bio-Plex Pro™ Human Cytokine Screening Panel (Biorad) and the Bio-Plex Multiplex system.ResultsThe study demonstrated that serum levels of MIP-1α, RANTES, Eotaxin, CTACK, GRO-α, IP-10, MIG, basic-FGF, HGF, SCGF-β, G-CSF, M-CSF, SCF, MIF, LIF, and TRAIL were significant higher in COVID-19 patients than in the control group. The concentrations of CTACK, GRO-α, IP-10, MIG, basic-FGF, HGF, PDGF- BB, GM-CSF, SCF, LIF, and TRAIL were higher in asymptomatic/mildly symptomatic COVID-19 patients (stage 1) and COVID-19 patients with pneumonia without respiratory failure (stage 2). The receiver operating characteristic (ROC) analysis revealed that IP-10, MIF, MIG, and basic-FGF differentiated patients with COVID-19 from healthy controls with the highest sensitivity and specificity, whereas GM-CSF, basic-FGF, and MIG differentiated asymptomatic/mildly symptomatic COVID-19 patients (stage 1) from COVID-19 patients with pneumonia without respiratory failure (stage 2) with the highest sensitivity and specificity.ConclusionsMIG, basic-FGF, and GM-CSF can be useful biomarkers for monitoring disease severity in patients with COVID-19.

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Section: Discussionmentioning

confidence: 99%

Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study

Wolszczak-Biedrzycka,

Dorf,

Wojewódzka-Żelezniakowicz

et al. 2024

Front. Immunol.

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Hospitalized COVID-19 Patients with Urinary Tract Infection in Iran: Candida Species Distribution and Antifungal Susceptibility Patterns

Shiyadeh,

Farahyar,

Vahedi Larijani

et al. 2024

Antibiotics

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Candida species, typically part of the human skin and mucous membrane flora, can cause opportunistic fungal infections, notably urinary tract infections (UTIs), which are on the rise among hospitalized COVID-19 patients. The lack of understanding of UTIs in this population, coupled with the emergence of multidrug-resistant strains, poses significant challenges for effective treatment and further investigations. In this study, urine samples were collected from 70 COVID-19 patients with UTIs in sterile containers for microbiology examination. After microscopic observation, the isolates were identified both by phenotypic and molecular techniques such as multiplex PCR. Antifungal susceptibility testing (AFST) against fluconazole (Flu), itraconazole (Itr), and amphotericin B (AMB) was performed according to CLSI M27/S4 standard methods, with the frequency of isolates including Candida albicans (n = 20, 51.3%), Candida tropicalis (n = 15, 38.4%), Nakaseomyces glabrata (previously Candida glabrata) (n = 2, 5.1%), Pichia kudriavzevii (previously Candida krusei), and Candida parapsilosis (n = 1, 2.5%). All isolates of C. albicans, C. tropicalis, C. glabrata, and C. parapsilosis were sensitive to amphotericin B, while C. kruzei was resistant to AMB. Around 70% of C. albicans isolates were sensitive to Flu; 20% of C. tropicalis were resistant to itraconazole, while 33% were resistant to fluconazole. C. albicans and C. tropicalis were the main causes of candiduria in infected cases and both Flu and AMB showed good results in AFST in these species. Performing drug susceptibility testing for clinical isolates of Candida spp. provided guidance for appropriate management and control, and timely antifungal treatment.

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COVID-19 and candiduria: an investigation of the risk factors and immunological aspects

Cited by 2 publications

References 33 publications

Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study

Changes in chemokine and growth factor levels may be useful biomarkers for monitoring disease severity in COVID-19 patients; a pilot study

Hospitalized COVID-19 Patients with Urinary Tract Infection in Iran: Candida Species Distribution and Antifungal Susceptibility Patterns

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