COVID-19 and cancer: 1 year on

COVID-19 vaccines in patients with cancer

“… 1 Patients with cancer have been included in the priority category for vulnerability to COVID-19 since the early phases of the pandemic. 2 There is, therefore, an urgent need to better understand the efficacy and safety of COVID-19 vaccines in immunosuppressed individuals, as recurrent exclusion of these and other vulnerable groups from ongoing studies of COVID-19 vaccines will result in imprecise predictive health models, which will in turn have consequences on successive waves of the pandemic. 3 …”

Adherence to COVID-19 vaccines in cancer patients: promote it and make it happen!

“…They have been excluded from the pivotal clinical trials for COVID19 vaccines despite included in the priority category for COVID19 vulnerability. (1) Few data are available on efficacy and safety profiles of vaccines against SARS-CoV-2 in patients with cancer, resulting in imprecise predictive health models. (2,3) Recently has been reported a first analysis on efficacy of SARS-CoV-2 vaccine in the a context of a prospective study enrolling patients and health care workers who received the RNA-based SARS-CoV-2 BNT162b2 vaccine ('BNT162b2'), with and without the boosting second dose at 3 weeks (4).…”

COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario

“…CML [01] 8. Hodgkin lymphoma [05] iii] Myeloid malignancy [14] Iv] Lymphoid malignancy [40] Decreased platelet count, WBC, hemoglobin, total lymphocyte count, Elevated ferritin, D- Dimer, LDH 1. DM (80) 2.…”

“…A prime example of COVID associated cataclysm is the humongous number of more than 4•6 million people on waiting lists for surgery in UK only which is a waiting period 100 times higher compared to that of the normal times. [14] . According to GLOBOCAN 2020 estimations, lung, colorectal, liver, stomach and female breast cancers are the prime causes of cancer death responsible for 18.0%, 9.4%, 8.3%, 7.7% and 6.9% of total global cancer-related fatalities, respectively.…”

“…According to GLOBOCAN 2020 estimations, lung, colorectal, liver, stomach and female breast cancers are the prime causes of cancer death responsible for 18.0%, 9.4%, 8.3%, 7.7% and 6.9% of total global cancer-related fatalities, respectively. With an approximate 19.3 million new cases and 10 million cancer deaths worldwide in 2020, Asia, Europe and America witnessed 58.3%, 19.6% and 14.2% of the total malignancy-related deaths, respectively [14] . Altered immunological state with increased inflammatory pathways [15] , higher expression of host genes which are pivotal in viral activation and amplification, [ 16 , 17 ] and host epigenetic alterations associated with viral infections may contribute to the higher susceptibilities seen in cancer patients suffering from Covid-19 18 , 19 , 20 .…”