COVID-19 and arrhythmia: An overview

Varney, Joseph; Dong, Vinh; Tsao, Tiffany; Sabir, Mariam S; Rivera, A.; Ghula, Suhaib; Moriles, Kevin; Cherukuri, Mohana Laasya; Fazal, Rahim; Azevedo, Chelsea B; Mohamed, Rana Mk; Jackson, Garrett R.; Fleming, Shannon E; Rochez, Diana E; Abbas, Kirellos Said; Shah, Jaffer; Minh, Le Huu Nhat; Osman, Faizel; Rafla, Samir; Huy, Nguyen Tien

doi:10.1016/j.jjcc.2021.11.019

Cited by 35 publications

(36 citation statements)

References 55 publications

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“…Systemic side effects have also been reported with varying incidences across studies (13.5–33.7%), including fatigue, headache, myalgia, fever, and diarrhea [ 4 , 5 ]. A common adverse effect is a palpitation [ 6 ]. A study conducted on 5866 health care workers (5589 who received ChAdOx1 (AstraZeneca) and 277 who received BNT162b2 (Pfizer/BioNTech)) revealed that 27.3% of participants reported palpitations (28.3% in the ChAdOx1 group and 4.3% in the BNT162b2 group) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Arrhythmias after SARS-CoV-2 Vaccination in Patients with a Cardiac Implantable Electronic Device: A Multicenter Study

et al. 2022

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One of the most concerning adverse events related to the SARS-CoV-2 vaccination is arrhythmia. To ascertain the relationship between vaccination and arrhythmic events, we studied the occurrence of arrhythmia in patients with cardiac implantable electronic devices (CIEDs) before and after a SARS-CoV-2 vaccination. Patients with CIEDs aged ≥18 who visited the CIED clinic at King Chulalongkorn Memorial Hospital and Vajira hospital from August 2021 to February 2022 were included. Information about the SARS-CoV-2 vaccination and side effects was obtained. One hundred eighty patients were included in our study, which compared the incidence of arrhythmias in the 14 days post-vaccination to the 14 days before vaccination. The median age was 70 years. The number of patients who received one, two, and three doses of the vaccine was 180, 88, and 4, respectively. ChAdOx1 was the primary vaccine used in our institutes, accounting for 86% of vaccinations. The vaccination was significantly associated with a 73% increase incidence of supraventricular tachycardia (SVT). In an adjusted model, factors associated with the incidence of SVT were the post-vaccination period, female sex, increasing BMI, chronic kidney disease, and a history of atrial fibrillation. Increased ventricular arrhythmia (VA) episodes were also associated with the post-vaccination period, female sex, decreasing BMI, and chronic kidney disease, but to a lesser degree than those with SVT episodes. No life-threatening arrhythmia was noted in this study. In conclusion, the incidence of arrhythmia in patients implanted with CIEDs was significantly increased after the SARS-CoV-2 vaccination.

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Section: Introductionmentioning

confidence: 99%

Arrhythmias after SARS-CoV-2 Vaccination in Patients with a Cardiac Implantable Electronic Device: A Multicenter Study

et al. 2022

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“…A recent meta-analysis showed that pooled incidence of cardiac arrhythmias is 16% among overall COVID-19 patients, being the second (after myocardial infarction) most common cardiac complication of COVID-19 [ 4 ]. The proposed pathophysiological mechanism involved in the development of the COVID-19-related arrhythmia includes hypoxemia, myocardial ischemia/hypoxia, systemic inflammation with hypercytokinemia (cytokine storm), dyselectrolytemias, and side effects of some antiviral drugs [ 5 , 6 ]. As COVID-19 is a systemic hyperinflammatory disease significantly impairing respiratory function, and the latter factors have long been known as being pro-arrhythmic in many other clinical entities, these assumptions are fully justified, while the mentioned mechanisms most likely contribute to the development of COVID-19-driven arrhythmias.…”

Section: Discussionmentioning

confidence: 99%

Detection of SARS-CoV-2 Antigens in the AV-Node of a Cardiac Conduction System—A Case Report

et al. 2022

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Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavirus disease (COVID-19), posing additional mortality risk in older-aged and critically ill patients. However, the underlying mechanisms and cardio pathological substrates of COVID-related arrhythmias have not been clarified yet. Here, we report findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and genes in the atrioventricular node (AV-node) of a cardiac conduction system, pointing to its direct infection as a possible arrhythmogenic factor.

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“…Arrhythmias during COVID-19 have been associated with several factors, such as electrolyte imbalances, preexisting heart conditions, medications that prolong the QT interval, virus-induced inflammation, and hypoxemia observed in patients with severe disease or critically ill. 63 Patients with COVID-19 have been affected as many other patients as possible with bradyarrhythmias or tachyarrhythmias (e.g., sinus tachycardia, atrial fibrillation and/or atrial flutter, ventricular arrhythmias, and others). Bradyarrhythmia cases were suggested to be associated with increased mortality among COVID-19 patients.…”

Section: Arrhythmiasmentioning

confidence: 99%

“…64 Patients with COVID-19 with evidence of fevers, inflammation, and hypoxemia develop sinus tachycardia. 63 In a systematic review and meta-analysis of 19 studies including 33,296 hospitalized patients with COVID-19, the diagnosis of atrial fibrillation and/or atrial flutter was associated with poor clinical outcomes. 65 New atrial fibrillation and/or atrial flutter and any atrial fibrillation and/or atrial flutter were both associated with a two-fold risk of in-hospital mortality.…”

Section: Arrhythmiasmentioning

confidence: 99%

Cardiovascular Complications in Coronavirus Disease 2019—Pathogenesis and Management

Restrepo

Marín‐Corral

Rodriguez

et al. 2023

Semin Respir Crit Care Med

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The coronavirus disease 2019 (COVID-19) pandemic has caused a devastating impact on morbidity and mortality around the world. Severe acute respiratory syndrome-coronavirus-2 has a characteristic tropism for the cardiovascular system by entering the host cells and binding to angiotensin-converting enzyme 2 receptors, which are expressed in different cells, particularly endothelial cells. This endothelial injury is linked by a direct intracellular viral invasion leading to inflammation, microthrombosis, and angiogenesis. COVID-19 has been associated with acute myocarditis, cardiac arrhythmias, new onset or worsening heart failure, ischemic heart disease, stroke, and thromboembolic disease. This review summarizes key relevant literature regarding the epidemiology, diagnosis, treatment, and preventive measures related to cardiovascular complications in the setting of COVID-19.

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COVID-19 and arrhythmia: An overview

Cited by 35 publications

References 55 publications

Arrhythmias after SARS-CoV-2 Vaccination in Patients with a Cardiac Implantable Electronic Device: A Multicenter Study

Arrhythmias after SARS-CoV-2 Vaccination in Patients with a Cardiac Implantable Electronic Device: A Multicenter Study

Detection of SARS-CoV-2 Antigens in the AV-Node of a Cardiac Conduction System—A Case Report

Cardiovascular Complications in Coronavirus Disease 2019—Pathogenesis and Management

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