COVID-19 and Aging-Related Genome (Chromosome) Instability in the Brain: Another Possible Time-Bomb of SARS-CoV-2 Infection

Iourov, Ivan Y.; Vorsanova, Svetlana G.

doi:10.3389/fnagi.2022.786264

Cited by 4 publications

(2 citation statements)

References 29 publications

(55 reference statements)

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“…Therefore, as noticed previously [129], environmental interactions with changed genomes should not be left aside in studies dedicated to somatic cell genomics of brain disorders. To support this idea, one can refer to the ability of the notorious COVID-19 virus to produce aging-related genome/chromosome instability in the diseased brain [140]. Thus, therapeutic interventions based on analysis of brain-specific somatic mosaicism are to be developed taking into account genetic-environmental interactions.…”

Section: What Is Now and What Is Next?mentioning

confidence: 99%

Somatic mosaicism in the diseased brain

et al. 2022

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It is hard to believe that all the cells of a human brain share identical genomes. Indeed, single cell genetic studies have demonstrated intercellular genomic variability in the normal and diseased brain. Moreover, there is a growing amount of evidence on the contribution of somatic mosaicism (the presence of genetically different cell populations in the same individual/tissue) to the etiology of brain diseases. However, brain-specific genomic variations are generally overlooked during the research of genetic defects associated with a brain disease. Accordingly, a review of brain-specific somatic mosaicism in disease context seems to be required. Here, we overview gene mutations, copy number variations and chromosome abnormalities (aneuploidy, deletions, duplications and supernumerary rearranged chromosomes) detected in the neural/neuronal cells of the diseased brain. Additionally, chromosome instability in non-cancerous brain diseases is addressed. Finally, theoretical analysis of possible mechanisms for neurodevelopmental and neurodegenerative disorders indicates that a genetic background for formation of somatic (chromosomal) mosaicism in the brain is likely to exist. In total, somatic mosaicism affecting the central nervous system seems to be a mechanism of brain diseases.

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Section: What Is Now and What Is Next?mentioning

confidence: 99%

Somatic mosaicism in the diseased brain

et al. 2022

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“…Moreover, these studies provided for ground-breaking achievements in medical cytogenetics (cytogenomics) -the treatment of chromosomal disorders, which are presumably incurable genetic conditions [102,103]. Finally, paying a tribute to our time, the latest bioinformatic research of Svetlana was focused on the impact of COVID-19 on biomedical publishing [104] and cellular genomes [105]. The results of these studies became a glorious finish of bioinformatic chapter of Svetlana's research and… life.…”

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confidence: 99%

Svetlana G. Vorsanova (1945–2021)

Iourov

2022

Mol Cytogenet

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Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly?

Petersen,

Chudakova,

Erdyneeva

et al. 2023

BioComm

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COVID-19 pandemic was caused by SARS-CoV-2, a novel virus from the family Coronaviridae, firstly identified in Wuhan, China in 2019. COVID-19 remains one of the main challenges of healthcare, given growing numbers of people with COVID-19 in anamnesis, and given the long-lasting consequences and complications of this disease. Cancer is one of the most common diseases in the world, thus a big part of the population is affected by both COVID-19 and cancer. In this succinct review we refer to several recent works expressing a view that COVID-19 might be oncogenic, and describe molecular mechanisms of such phenomena. Next, we describe several tumorigenic changes in the tissue microenvironment as COVID-19 sequelae, which can potentially affect cancer pathogenesis and response of a tumor to therapy. 3D cell culture models are a “golden standard” of in vitro studies in translational oncology. To the best of our knowledge, 3D cell culture systems to study tumor behavior in the tissue microenvironment affected by COVID-19 have not been developed yet. We propose several actionable steps which can be taken to modify existing 3D cell culture models accordingly, to address the needs of translational oncology in the COVID-19 post-pandemic times.

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COVID-19 and Aging-Related Genome (Chromosome) Instability in the Brain: Another Possible Time-Bomb of SARS-CoV-2 Infection

Cited by 4 publications

References 29 publications

Somatic mosaicism in the diseased brain

Somatic mosaicism in the diseased brain

Svetlana G. Vorsanova (1945–2021)

Cancer as a potential sequela of COVID-19 — should we modify 3D cell culture models accordingly?

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