COVID‑19: An update of current knowledge (Review)

Pandey, Vaishnavi; Singh, Ajai; Siddiqui, Salma; Raikwar, Archana; Gond, Amit Kumar; Ali, Shahid; Yadav, Manish; Datta, Aashima; Singh, Anamika

doi:10.3892/wasj.2021.86

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…The HIF-1 (hypoxia-inducible factor-1α) signaling pathway, which plays an important role in virus infection and proinflammatory responses ( Tian et al, 2021 ; Serebrovska et al, 2020 ), was significantly enriched in gene expression profiles of Virofree treatment ( Figure 1B ), suggesting effects of the drug on this pathway to suppress IL-6 production, which is consistent with PCA loading scores ( Figure 1F ), and eventually inhibit the cytokine storm. GO enrichment indicated that Virofree can mediate clathrin-coated pit ( Alfarouk et al, 2021 ) and virus receptor activity, which are related to the virus–human entrance interaction ( Pandey et al, 2021 ). In contrast, the disease association via DO shows many COVID-19 symptoms or diseases in the upper range of Virofree treatment, including iron metabolism disorders, pulmonary arterial hypertension, idiopathic pulmonary hypertension, airway obstruction, and the common cold.…”

Section: Discussionmentioning

confidence: 99%

Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2

et al. 2022

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Coronavirus disease 2019 (COVID-19) remains a threat with the emergence of new variants, especially Delta and Omicron, without specific effective therapeutic drugs. The infection causes dysregulation of the immune system with a cytokine storm that eventually leads to fatal acute respiratory distress syndrome (ARDS) and further irreversible pulmonary fibrosis. Therefore, the promising way to inhibit infection is to disrupt the binding and fusion between the viral spike and the host ACE2 receptor. A transcriptome-based drug screening platform has been developed for COVID-19 to explore the possibility and potential of the long-established drugs or herbal medicines to reverse the unique genetic signature of COVID-19. In silico analysis showed that Virofree, an herbal medicine, reversed the genetic signature of COVID-19 and ARDS. Biochemical validations showed that Virofree could disrupt the binding of wild-type and Delta-variant spike proteins to ACE2 and its syncytial formation via cell-based pseudo-typed viral assays, as well as suppress binding between several variant recombinant spikes to ACE2, especially Delta and Omicron. Additionally, Virofree elevated miR-148b-5p levels, inhibited the main protease of SARS-CoV-2 (Mpro), and reduced LPS-induced TNF-α release. Virofree also prevented cellular iron accumulation leading to ferroptosis which occurs in SARS-CoV-2 patients. Furthermore, Virofree was able to reduce pulmonary fibrosis-related protein expression levels in vitro. In conclusion, Virofree was repurposed as a potential herbal medicine to combat COVID-19. This study highlights the inhibitory effect of Virofree on the entry of Delta and Omicron variants of SARS-CoV-2, which have not had any effective treatments during the emergence of the new variants spreading.

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Section: Discussionmentioning

confidence: 99%

Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2

et al. 2022

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“…En cuanto a las características clínicas de la enfermedad, otro punto de contraste entre los odontólogos encuestados fue la dificultad de no encontrar sintomatología exclusiva que diferencie el contagio de COVID-19 en relación a otras patologías respiratorias. Aún así, al inicio de la pandemia se en-contró que gran cantidad de los pacientes presentaban anosmia, ageusia, mialgias y alteraciones gastrointestinales; lo que ayudó para una diferenciación más efectiva 14 . En este sentido, la gran mayoría de odontólogos concertó en que todos los síntomas respiratorios, deberían ser tomados como posibles sospechosos de COVID-19, hasta la confirmación de su diagnóstico.…”

Section: Conocimiento De Covid-19unclassified

Conocimiento, actitud y percepción de los odontólogos ante el COVID-19

Basantes Portilla,

Santórum Chiriboga

2023

MetroCiencia

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La Organización Mundial de la Salud declaró el brote del nuevo coronavirus (COVID-19) como pandemia el 11 de marzo de 2020 debido a su rápida propagación a escala mundial. Los odontólogos tienen un alto riesgo de contraer infecciones por el nuevo coronavirus debido a las gotas y aerosoles generados durante los procedimientos dentales en pacientes potencialmente infectados. Por esto, el conocimiento, la percepción y la actitud de estos trabajadores se consideran importantes para prevenir y controlar el brote. Los resultados del presente artículo indican que la mayoría de los odontólogos tienen un conocimiento adecuado y buenos puntajes de actitud y percepción, lo cual es primordial para combatir el COVID-19. Sin embargo, todavía existen muchas falencias que deben mejorar para garantizar una práctica dental segura tanto para los pacientes como para los profesionales.

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“…The first group includes review articles. Such articles describe the basic virology of SARS-CoV-2, such as genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses (Boldyreva, 2020;Borges do Nascimento et al, 2021;Chams et al, 2020;Holmes et al, 2021;Hu et al, 2021;Pandey et al, 2021;Pathak, 2021;Sharma et al, 2021).…”

Section: Literature Reviewmentioning

confidence: 99%

Covid-19: Systems Transdisciplinary Generalization, Technical and Technological Ideas, and Solutions

Mokiy¹,

Lukyanova²

2022

InformingSciJ

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Aim/Purpose: The Covid-19 pandemic has created many adverse effects. It overloads the healthcare system, causes deaths, and angers some at anti-covid restrictions. This study examines the feasibility of using technical and technological ideas to overcome these effects. The solution is based on new knowledge about the virus, its nature, formation, and activation in the environment. Background: The rapid spread of a new coronavirus infection is taking place against the background of a lack of time required to create new treatment scenarios for the disease, development, production, and vaccine safety research. In such a situation, it became necessary to gain this time for organizing and conducting events that could reduce the burden on the healthcare system. Methodology: The science that studies the morphology, physiology, genetics, ecology, and evolution of viruses is virology. The modern development of virology is moving towards a more accurate and comprehensive description of the mechanisms of interaction of viruses with the host organism. This contributed to the emergence of genomics, transcriptomics, proteomics, and immunomics. However, in virology, there is no particular discipline that sets itself three fundamental goals: to substantiate a single concept of the emergence of viruses; to study the natural mechanisms of formation of virus molecules in the environment; to describe the natural mechanisms of activation of certain viruses in the environment that cause viral pandemics. As a result, there are many articles among the published scientific articles on viruses dealing with the mechanisms of interaction of viruses with the host organism. However, there are no articles on the natural mechanisms of formation and activation of certain viruses in the environment. In the absence of such specialized articles, we were forced to use the method of systems transdisciplinary generalization of disciplinary knowledge to achieve our article’s purpose. Generalization created new knowledge about the nature of viruses, about the mechanisms of their formation and activation in the environment and cells of biological organisms. It is logical to assume that to synchronize the state of biological objects of all functional ensembles on the planet, it is necessary to create and activate appropriate “technological tools.” We have suggested and proved that RNA viruses play the role of such tools. Piezoelectricity activates viruses. It occurs during the compression and stretching of sedimentary rocks and bases of continental plates in different territories. Contribution: The systems transdisciplinary generalization of the knowledge of scientific disciplines made it possible to edit the concept of viruses, to eliminate stereotypes that arose due to the use of unsuccessful analogies. As a result of this generalization, it was possible to prove that viruses are not intracellular parasites. The virus is a “technological tool” of the planetary organizing component. This “tool” aims to correct the genetic programs of organisms of all functional ensembles (plants, animals, people), which will maintain the state of organisms and the parameters of their metabolism in changing environmental conditions. Findings: The viruses that triggered pandemics in the 20th century and early 21st century are RNA viruses. RNA molecules play the role of “technological tools” that the planetary organizing component uses to carry out short-term and long-term adjustments and constant support of the genetic programs of biological organisms. Therefore, in such a situation, it is advisable to talk not about the fight against the virus but only about eliminating the negative manifestations of the Covid-19 pandemic: reducing the number of people in need of emergency hospitalization, eliminating cases of the acute course of the disease and deaths. It is proposed to use certain technical and technological ideas and solutions to eliminate these negative manifestations. Recommendation for Researchers: This paper recommends that researchers use new interdisciplinary and transdisciplinary approaches. They challenge assumptions and conclusions about the nature of viruses, and the mechanisms of their formation and activation in the environment can initiate. Such new research might describe the mechanisms that form and activate viruses in the environment and the body’s cells. They also might provide practical use of this knowledge to eliminate the multiple speculations and fears that arise against the background of reports of the likely appearance of more deadly viruses and viral infections. Future Research: The results of a systems transdisciplinary generalization of disciplinary knowledge about the nature and purpose of viruses are essential for expanding the horizon of the scientific worldview. Future fundamental research on the mechanisms of objective organizing constituents, a general description given in this article, will contribute to a deeper understanding of chemical and biological evolution mechanisms in which modern humanity is involved. In due time, such an understanding will allow a new look at the existing scenarios of the world socio-economic order, explore and describe new principles of sustainable development of society.

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COVID‑19: An update of current knowledge (Review)

Cited by 5 publications

References 27 publications

Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2

Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2

Conocimiento, actitud y percepción de los odontólogos ante el COVID-19

Covid-19: Systems Transdisciplinary Generalization, Technical and Technological Ideas, and Solutions

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