COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?

Saeedi-Boroujeni, Ali; Mahmoudian-Sani, Mohammad Reza; Bahadoram, Mohammad; Alghasi, Arash

doi:10.1111/bcpt.13503

Cited by 46 publications

(42 citation statements)

References 64 publications

(109 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that colchicine can nonselectively inhibit NLRP3 inflammation by inhibiting the activation of P2X7 receptor or the interaction between NLRP3 protein and ASC. 350 , 351 In addition, chloroquine 352 and curcumin 353 are also capable of inhibiting NLRP3 signaling. Several investigational agents capable of inhibiting NLRP3 activation, such as tranilast, 354 dapansutrile (OLT1177, selective inhibitor), 354 and thiazolo-alkenyl sulfonylurea derivative 7, 355 are also being considered for COVID-CS treatment as reviewed by Freeman and Swartz.…”

Section: Blockade Of Signaling Pathwaysmentioning

confidence: 99%

The signal pathways and treatment of cytokine storm in COVID-19

Yang

Xie

et al. 2021

Sig Transduct Target Ther

400

413

View full text Add to dashboard Cite

The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis and is more devastating than any other previous infectious disease. It has affected a significant proportion of the global population both physically and mentally, and destroyed businesses and societies. Current evidence suggested that immunopathology may be responsible for COVID-19 pathogenesis, including lymphopenia, neutrophilia, dysregulation of monocytes and macrophages, reduced or delayed type I interferon (IFN-I) response, antibody-dependent enhancement, and especially, cytokine storm (CS). The CS is characterized by hyperproduction of an array of pro-inflammatory cytokines and is closely associated with poor prognosis. These excessively secreted pro-inflammatory cytokines initiate different inflammatory signaling pathways via their receptors on immune and tissue cells, resulting in complicated medical symptoms including fever, capillary leak syndrome, disseminated intravascular coagulation, acute respiratory distress syndrome, and multiorgan failure, ultimately leading to death in the most severe cases. Therefore, it is clinically important to understand the initiation and signaling pathways of CS to develop more effective treatment strategies for COVID-19. Herein, we discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines involved. We also discuss the induction, function, downstream signaling, and existing and potential interventions for targeting these cytokines or related signal pathways. We believe that a comprehensive understanding of CS in COVID-19 will help to develop better strategies to effectively control immunopathology in this disease and other infectious and inflammatory diseases.

show abstract

Section: Blockade Of Signaling Pathwaysmentioning

confidence: 99%

The signal pathways and treatment of cytokine storm in COVID-19

Yang

Xie

et al. 2021

Sig Transduct Target Ther

400

413

View full text Add to dashboard Cite

show abstract

“…Due to the uncountable mechanisms of action addressed in this and other reviews, it has been reinforced that curcumin could serve as an adjuvant drug in COVID-19 treatment (Babaei et al, 2020;Manoharan et al, 2020;Roy et al, 2020;Soni et al, 2020;Zahedipour et al, 2020;Saeedi-Boroujeni et al, 2021;Thimmulappa et al, 2021). The multiplicity of pathophysiological responses induced by SARS-CoV-2 highlights the need for a combination of different drugs as a treatment strategy (i.e., there is no single "magic pill" for the cure of COVID-19).…”

Section: Discussionmentioning

confidence: 95%

Curcumin as a Potential Treatment for COVID-19

2021

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a challenge. One of the best strategies around the world to help combat the COVID-19 has been directed to drug repositioning; however, these drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host remains unidentified, despite recent discoveries. This complex and multifactorial response requires a comprehensive therapeutic approach, enabling the integration and refinement of therapeutic responses of a given single compound that has several action potentials. In this context, natural compounds, such as Curcumin, have shown beneficial effects on the progression of inflammatory diseases due to its numerous action mechanisms: antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, the purpose of this review is to specifically point out how curcumin could interfere at different times/points during the infection caused by SARS-CoV-2, providing a substantial contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19.

show abstract

“…Other medicinal compounds used to target SARS-CoV-2 that inhibit activation of the TXNIP/NLRP3 inflammasome by regulating AMPK are curcumin [ 178 ] and the nutraceutical berberine [ 177 ].…”

Section: Ampk and Covid-19mentioning

confidence: 99%

Multifaceted Role of AMPK in Viral Infections

Bhutta

Gallo²,

Borenstein

2021

Cells

View full text Add to dashboard Cite

Viral pathogens often exploit host cell regulatory and signaling pathways to ensure an optimal environment for growth and survival. Several studies have suggested that 5′-adenosine monophosphate-activated protein kinase (AMPK), an intracellular serine/threonine kinase, plays a significant role in the modulation of infection. Traditionally, AMPK is a key energy regulator of cell growth and proliferation, host autophagy, stress responses, metabolic reprogramming, mitochondrial homeostasis, fatty acid β-oxidation and host immune function. In this review, we highlight the modulation of host AMPK by various viruses under physiological conditions. These intracellular pathogens trigger metabolic changes altering AMPK signaling activity that then facilitates or inhibits viral replication. Considering the COVID-19 pandemic, understanding the regulation of AMPK signaling following infection can shed light on the development of more effective therapeutic strategies against viral infectious diseases.

show abstract

COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?

Cited by 46 publications

References 64 publications

The signal pathways and treatment of cytokine storm in COVID-19

The signal pathways and treatment of cytokine storm in COVID-19

Curcumin as a Potential Treatment for COVID-19

Multifaceted Role of AMPK in Viral Infections

Contact Info

Product

Resources

About