COVID-19: A brief overview on the role of Vitamins specifically Vitamin C as immune modulators and in prevention and treatment of SARS-Cov-2 infections

Abstract

In December 2019 a pandemic of acute respiratory distress syndromes occurs in Wuhan, china, the early evidence suggests this may be due to exposure to local sea foods in china. The pathogen was isolated from Chinese patients and designated as severe acute respiratory syndrome corona virus 2 (SARS-COV-2). COVID-19 mainly affects lungs by producing respiratory predominant symptoms like fever, cough, flu and dyspnea. As SARS-Cov-2 firstly find a mechanism to escape the immune system of humans and animals followed by a huge release of cytokines named as cytokine storms and the hyper activation of the other immune system responses. To avoid these conditions in any type of viral infections such as in SARS-Cov-2 infections and influenza virus induce lung injury vitamin D is now is recently considered as proposed therapy. Vitamin C acts as strong antioxidant and help to scavenge all the damaged species that is why vitamin C is regarded helpful in SARS-Cov-2 and other viral infections. Many findings from different clinical studies show that vitamin C when administrated orally can reduce SAR-Cov-2 and other viral infection. Taking vitamin C intravenously has also profound effect on the reduction of viral infections. As health care workers and professional are risk community for COVID-19 so vitamin C should be included in prevention and treatment of COVID-19 in this community. As vitamin C is also a prooxidant so smaller pharmacological concentration of vitamin C milli-molar is beneficial. But in case of COVID-19 high intravenous dose of vitamin C would be the right choice.symptoms like fever, cough, flu and dyspnea [2]. The virus primarily

Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria

“…25 Vitamins C and E are found to be helpful in cytokine storms and cellular injury which are the outcomes of SARS-COV-2 and other viral infections. Vitamins C and E act as strong antioxidants and help to scavenge the ROS, which is why Jan et al 26 regarded these vitamins as helpful in SARS-Cov-2 and other viral infections. The reduced level of these vitamins observed in this study is owing to their role in scavenging ROS as they are being used up in the process.…”

Multifactorial utility of vitamins in treatment of covid – 19

“…[36,37,38] Due to these actions, Vitamin C has a potential in the management of COVID-19 patients. [39,40,41] Vitamin C supplementation has shown beneficial results in infections and sepsis. As extreme COVID-19 can also induce acute respiration distress syndrome (ARDS) and sepsis, excessive doses of vitamin C supplementation may also contribute to ameliorating inflammation in patients with COVID-19.…”

Pengalaman Perawatan Diri Para Perawat Yang Merawat Pasien Covid-19 Di Rumah Sakit Swasta Indonesia

“…Hasil penelitian ini ditemukan bahwa partisipan mengkonsumsi vitamin C pada saat merawat pasien COVID-19. Vitamin C bertindak sebagai antioksidan kuat, itulah sebabnya vitamin C dianggap bermanfaat dalam SARS-Cov-2 dan infeksi virus lainnya (Khan et al, 2020), seperti juga yang dikatakan oleh Soledad (2021) bahwa, Vitamin C dapat membantu mengurangi risiko badai sitokin dan mendukung sistem kekebalan tubuh.…”

“…Karena vitamin C juga merupakan pro-oksidan, maka konsentrasi farmakologis vitamin C mili-molar yang lebih kecil bermanfaat. Tetapi dalam kasus COVID-19, vitamin C dosis tinggi intravena akan menjadi pilihan yang tepat (Khan et al, 2020) terkecuali menggunakan alat pelindung diri ketika merawat pasien COVID 19. Ketika penyakit menular pernapasan baru menyebar luas, seperti selama pandemi COVID-19, kepatuhan petugas kesehatan terhadap pedoman pencegahan dan pengendalian infeksi (PPI) menjadi lebih penting.…”