Covert Pathogenesis of NO<sub>2</sub>Induced Emphysema in the Rat

Haydon, Glen; Freeman, Gustave; Furiosi, N.J.

doi:10.1080/00039896.1965.10664300

Cited by 54 publications

(10 citation statements)

References 5 publications

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“…In 1968, a rodent model of experimental emphysema was described in which rats exposed to 10 to 25 ppm of ambient nitrogen dioxide (NO 2 , a nitrite gaseous precursor) developed emphysematous changes in their lungs (5)(6)(7). In 1972, Shuval and Gruener added 1,000 to 3,000 mg/L sodium nitrite to the drinking water of rats for a 2-year period (8).…”

mentioning

confidence: 99%

Cured Meat Consumption, Lung Function, and Chronic Obstructive Pulmonary Disease among United States Adults

Jiang

Paik²,

Hankinson³

et al. 2007

Am J Respir Crit Care Med

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Rationale: Cured meats are high in nitrites. Nitrites generate reactive nitrogen species that may cause nitrative and nitrosative damage to the lung resulting in emphysema. Objective: To test the hypothesis that frequent consumption of cured meats is associated with lower lung function and increased odds of chronic obstructive pulmonary disease (COPD). Methods: Cross-sectional study of 7,352 participants in the Third National Health and Nutrition Examination Survey, 45 years of age or more, who had adequate measures of cured meat, fish, fruit, and vegetable intake, and spirometry. Results: After adjustment for age, smoking, and multiple other potential confounders, frequency of cured meat consumption was inversely associated with FEV 1 and FEV 1 /FVC but not FVC. The adjusted differences in FEV 1 between individuals who did not consume cured meats and those who consumed cured meats 1 to 2, 3 to 4, 5 to 13, and 14 or more times per month were ؊37.6, ؊11.5, ؊42.0, and ؊110 ml, respectively (p for trend Ͻ 0.001). Corresponding differences for FEV 1 /FVC were ؊0.91, ؊0.54, ؊1.13, and ؊2.13% (p for trend ϭ 0.001). These associations were not modified by smoking status. The multivariate odds ratio for COPD (FEV 1 /FVC р 0.7 and FEV 1 Ͻ 80% predicted) was 1.78 (95% confidence interval, 1.29-2.47) comparing the highest with the lowest category of cured meat consumption. The corresponding odds ratios for mild, moderate, and severe COPD were 1.11, 1.46, and 2.41, respectively. Conclusions: Frequent cured meat consumption was associated independently with an obstructive pattern of lung function and increased odds of COPD. Additional studies are required to determine if cured meat consumption is a causal risk factor for COPD.

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confidence: 99%

Cured Meat Consumption, Lung Function, and Chronic Obstructive Pulmonary Disease among United States Adults

Jiang

Paik²,

Hankinson³

et al. 2007

Am J Respir Crit Care Med

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“…Chronic exposure could result in alterations in lung architecture resembling those of emphysema. 35,36 Studies of ozone described inflammatory and biochemical changes in the airways after ozone exposure. [37][38][39] Ozone-induced airway reactivity to methacholine was associated with polymorphonuclear leukocyte (PMN) influx into airways with interleukin 8 and changes in cyclooxygenase metabolites of arachidonic acid.…”

Section: Discussionmentioning

confidence: 99%

Decreased Lung Function Associated With Occupational Exposure to Epichlorohydrin and the Modification Effects of Glutathione S-Transferase Polymorphisms

Luo

Cheng

Kuo

et al. 2004

Journal of Occupational and Environmental Medicine

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Epichlorohydrin (1-chloro-2,3,-epoxypropane; ECH) is a strong irritant of the eyes, respiratory tract, and skin. Because the toxic effect of various chemicals can be modified by metabolic traits, in this study, we also investigated the influence of the glutathione S-transferase (GSTM1) and (GSTT1) genes on the toxic effect of ECH. In the GSTM1 null genotype workers, there is a dose-response of lung function tests (FEV1, FEV1/FVC, MMEF) for ECH exposure, but not in the GSTM1 non-null genotype workers. The ECH exposure was found to be significantly associated with a decreased FEV1 value (P = 0.09) and a decreased MMEF value (P = 0.053) after adjusting for other factors. The GSTM1 null genotype was found to be significantly associated with a decreased FEV1 value (P = 0.038), decreased FEV1/FVC value (P = 0.056), and decreased MMEF value (P = 0.012) after adjusting for other factors. This study indicates that obstructive lung abnormalities and small airway lung damage are associated with ECH exposure, and ECH workers with GSTM1 null-type are also associated with increased respiratory damage.

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“…The chapters on treatment make sad reading. The authors recognise that all treatment is palliative and survival is unlikely to be more than [12][13][14] months. Surgical treatment is either by pleurectomy or extra pleural pneumonectomy either with or without the diaphragm.…”

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confidence: 99%

Update on lung disease in coalminers.

Kennedy¹

1987

Occupational and Environmental Medicine

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Covert Pathogenesis of NO₂Induced Emphysema in the Rat

Cited by 54 publications

References 5 publications

Cured Meat Consumption, Lung Function, and Chronic Obstructive Pulmonary Disease among United States Adults

Cured Meat Consumption, Lung Function, and Chronic Obstructive Pulmonary Disease among United States Adults

Decreased Lung Function Associated With Occupational Exposure to Epichlorohydrin and the Modification Effects of Glutathione S-Transferase Polymorphisms

Update on lung disease in coalminers.

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Covert Pathogenesis of NO2Induced Emphysema in the Rat

Cited by 54 publications

References 5 publications

Cured Meat Consumption, Lung Function, and Chronic Obstructive Pulmonary Disease among United States Adults

Cured Meat Consumption, Lung Function, and Chronic Obstructive Pulmonary Disease among United States Adults

Decreased Lung Function Associated With Occupational Exposure to Epichlorohydrin and the Modification Effects of Glutathione S-Transferase Polymorphisms

Update on lung disease in coalminers.

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Covert Pathogenesis of NO₂Induced Emphysema in the Rat