Covert orienting to exogenous and endogenous cues in children with spina bifida

Dennis, Maureen; Edelstein, Kim; Copeland, Kim; Frederick, Jon A.; Francis, D.; Hetherington, Ross; Blaser, Susan; Kramer, Larry A.; Drake, James M.; Brandt, Michael E.; Fletcher, Jack Μ.

doi:10.1016/j.neuropsychologia.2004.08.012

Cited by 47 publications

(63 citation statements)

References 33 publications

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“…1), frequently visualized in imaging studies of individuals with SBM, are unclear; for example, it is not known whether the aberrant structural formation of the tectum contributes to compromised or altered connectivity of white matter (WM) between this region and its cortical projections. Regardless, there are consistent findings linking qualitative abnormalities of the tectum to deficits in attention orienting in SBM (Dennis et al, 2005a).…”

Section: Introductionmentioning

confidence: 83%

“…Tectal beaking was associated with increased AD, in which individuals with SBM and a normal appearing tectum did not significantly differ from the TD comparison group. Thus, changes in AD along all pathways emanating from the colliculus may be uniquely related to developmental malformation of this structure in SBM and not simply to the mechanical effects of hydrocephalus, thus providing a potential mechanism for spatial attention deficits in SBM (Dennis et al, 2005a(Dennis et al, , 2005b.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier research has demonstrated specific deficits in attention orienting in children with SBM, with tectal beaking associated with a greater degree of attentional impairment. In particular, children with SBM and tectal beaking show deficits in covert orienting, as well as a higher cost of disengagement from currently selected stimuli when compared with controls, and with children with SBM and no tectal dysmorphometry (Dennis et al, 2005a). Children with SBM also demonstrate attenuated inability to re-engage a new target on a task measuring inhibition of return, with greater decrements in performance among children exhibiting tectal beaking (Dennis et al, 2005b).…”

Section: Attention Orienting In Sbmmentioning

confidence: 96%

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Examination of Frontal and Parietal Tectocortical Attention Pathways in Spina Bifida Meningomyelocele Using Probabilistic Diffusion Tractography

et al. 2013

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Abnormalities of the midbrain tectum are common but variable malformations in spina bifida meningomyelocele (SBM) and have been linked to neuropsychological deficits in attention orienting. The degree to which variations in tectum structure influence white matter (WM) connectivity to cortical regions is unknown. To assess the relationship of tectal structure and connectivity to frontal and parietal cortical regions, probabilistic diffusion tractography was performed on 106 individuals (80 SBM, 26 typically developing [TD]) to isolate anterior versus posterior tectocortical WM pathways. Results showed that those with SBM exhibited significantly reduced tectal volume, along with decreased fractional anisotropy (FA) in posterior but not anterior tectocortical WM pathways when compared with TD individuals. The group with SBM also showed greater within-subject discrepancies between frontal and parietal WM integrity compared with the TD group. Of those with SBM, qualitative classification of tectal beaking based on radiological review was associated with increased axial diffusivity across both anterior and posterior tectocortical pathways, relative to individuals with SBM and a normal appearing tectum. These results support previous volumetric findings of greater impairment to posterior versus anterior brain regions in SBM, and quantifiably relate tectal volume, tectocortical WM integrity, and tectal malformations in this population.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Attention Orienting In Sbmmentioning

confidence: 96%

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Examination of Frontal and Parietal Tectocortical Attention Pathways in Spina Bifida Meningomyelocele Using Probabilistic Diffusion Tractography

et al. 2013

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“…Autistic children with cerebellar hypoplasia exhibit impaired attentional shifts (Harris et al, 1999), as do adult patients with cerebellar or basal ganglia pathology (Ravizza and Ivry, 2001). Finally, children with spina bifida meningomyelocele (SBM) with congenital dysmorphology of the midbrain showed a higher cost of attentional disengagement and a lack of IOR compared to either healthy controls or children with SBM with no midbrain dysmorphology (Dennis et al, 2005).…”

Section: Orienting In Pediatric Mild Tbimentioning

confidence: 99%

An fMRI Study of Auditory Orienting and Inhibition of Return in Pediatric Mild Traumatic Brain Injury

Yang

Yeo

Peña

et al. 2012

Journal of Neurotrauma

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Studies in adult mild traumatic brain injury (mTBI) have shown that two key measures of attention, spatial reorienting and inhibition of return (IOR), are impaired during the first few weeks of injury. However, it is currently unknown whether similar deficits exist following pediatric mTBI. The current study used functional magnetic resonance imaging (fMRI) to investigate the effects of semi-acute mTBI ( < 3 weeks post-injury) on auditory orienting in 14 pediatric mTBI patients (age 13.50 -1.83 years; education: 6.86 -1.88 years), and 14 healthy controls (age 13.29 -2.09 years; education: 7.21 -2.08 years), matched for age and years of education. The results indicated that patients with mTBI showed subtle (i.e., moderate effect sizes) but non-significant deficits on formal neuropsychological testing and during IOR. In contrast, functional imaging results indicated that patients with mTBI demonstrated significantly decreased activation within the bilateral posterior cingulate gyrus, thalamus, basal ganglia, midbrain nuclei, and cerebellum. The spatial topography of hypoactivation was very similar to our previous study in adults, suggesting that subcortical structures may be particularly affected by the initial biomechanical forces in mTBI. Current results also suggest that fMRI may be a more sensitive tool for identifying semi-acute effects of mTBI than the procedures currently used in clinical practice, such as neuropsychological testing and structural scans. fMRI findings could potentially serve as a biomarker for measuring the subtle injury caused by mTBI, and documenting the course of recovery.

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“…Eighteen month old infants with SBM have difficulty with visual attentions and dishabituation [37]. The problem continues in older children who have difficulty orienting to external stimuli and then, once engaged, terminating their focus [38]. Dennis and colleagues [39] compared the ability of typically developing children with that of children with SBM in performing a test of peripersonal spatial attention.…”

Section: Attentionmentioning

confidence: 99%

Evidence of Cerebellar Dysfunction in Children with Myelomeningocele?

Martin¹

2017

Phys Med Rehabil Int

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Structural differences in the development of the cerebellum in children with spina bifida myelomeningocele are associated with functional deficits in movement, timing, and attention. Furthermore, these structural and functional deficits contribute to uneven development of perception and cognition. Studies are reviewed that provide some understanding of the reason such a mixed pattern of assets and deficits within the same area is seen in these children. Motor learning and adaptation are relative strengths while predictive motor control is not. Upper limb function and visual perception are problematic as is timing and attention. In utero damage to the cerebellum may provide an explanation for this mixed pattern. Early damage can negatively impact the development of cerebellar circuits which could interfere with learning. Clinicians need to be aware of the relative strengths and weaknesses in children with spina bifida myelomeningocele in order to individualize early intervention treatment plans, optimize motor learning, and promote maximal participation in daily life.

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Covert orienting to exogenous and endogenous cues in children with spina bifida

Cited by 47 publications

References 33 publications

Examination of Frontal and Parietal Tectocortical Attention Pathways in Spina Bifida Meningomyelocele Using Probabilistic Diffusion Tractography

Examination of Frontal and Parietal Tectocortical Attention Pathways in Spina Bifida Meningomyelocele Using Probabilistic Diffusion Tractography

An fMRI Study of Auditory Orienting and Inhibition of Return in Pediatric Mild Traumatic Brain Injury

Evidence of Cerebellar Dysfunction in Children with Myelomeningocele?

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