Covert cavitation: Spectral peak suppression in the acoustic emissions from spatially configured nucleations

Song, Jae Hee; Johansen, Kristoffer; Prentice, Paul

doi:10.1121/1.4977236

Cited by 10 publications

(3 citation statements)

References 10 publications

(20 reference statements)

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“…4. This is due to the fact that the timings between respective shocks are not well replicated between the two representations, and therefore high frequency content is not adding at the correct phases in the simulated acoustic emissions [4,13]. From the results presented in Fig.…”

Section: B F 0 /3 Regimementioning

confidence: 82%

Validity of the Keller-Miksis equation for “non-stable” cavitation and the acoustic emissions generated

Johansen¹,

Song²,

Prentice³

2017

2017 IEEE International Ultrasonics Symposium (IUS)

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Abstract-The Keller-Miksis equation (KME) is commonly used for numerical studies of inertial and stable-inertial cavitation. However, experimental validation of KME under clinically relevant exposure settings is scarce, particularly in terms of the acoustic emission signal generated by the cavitation. In this paper, the KME is validated against a cavitation cloud collapsing f 0/2 and f0/3 sub-harmonically with some success. This could significantly aid the design of arrays for passive acoustic mapping (PAM), quantification of cavitation dose, and tuning controllers for feed-back-loops.

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Section: B F 0 /3 Regimementioning

confidence: 82%

Validity of the Keller-Miksis equation for “non-stable” cavitation and the acoustic emissions generated

Johansen¹,

Song²,

Prentice³

2017

2017 IEEE International Ultrasonics Symposium (IUS)

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“…Acoustic cavitation bubbles generated by intense ultrasound in water radiate secondary ultrasound called acoustic cavitation noise owing to their volumetric oscillation. [1][2][3][4][5] In sonochemistry, which is concerned with understanding the chemical effects associated with acoustic cavitation phenomena, [6][7][8][9][10][11] acoustic cavitation noise has been attracting attention as a method for monitoring acoustic cavitation conditions, and numerous research findings have been reported. [12][13][14][15][16][17] However, reports on the explicit use of acoustic cavitation noise other than monitoring are limited.…”

Section: Introductionmentioning

confidence: 99%

Theoretical analysis and experimental verification of spatial coherence of acoustic cavitation noise from bubble clusters under ultrasonic horn

Kuroyama,

Ogasawara,

Mori

2024

Jpn. J. Appl. Phys.

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Acoustic cavitation bubbles under ultrasonic horn in water emit acoustic cavitation noise, which consists of spherical shockwaves. This study theoretically derived the spatial coherence of acoustic cavitation noise or, more precisely, the spectral degree of coherence. The acoustic cavitation noise was found to have spatial coherence characteristics similar to the "thermal light" in optics, unlike ultrasound generated by general transducers, which are analogous to "laser" with high coherence. The experiments validated the derived theory and showed that the spectral degree of coherence of the acoustic cavitation noise depends on the product between the distribution width of the shockwave origin, proportional to the horn diameter, and the angle between the hydrophones viewed from the horn. The lower the product gives, the higher the spectral degree of coherence at a higher frequency range.

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“…PAM techniques use the FUS transducer as the emitter while a receiver array passively records the backscattered signal. PAM techniques are extensively characterized and are an improvement compared to conventional PCD monitoring, which has a poor spatiotemporal resolution as it can only detect cavitation events from a fixed volume and can lead to misinterpretation since signals from acoustic events can interfere with each other (Song et al 2017). Spatial resolution can be improved with the use of linear arrays and passive beamforming methods (Gyongy andCoussios 2010, Haworth et al 2017) but given that no imaging pulse is emitted, the axial resolution is suboptimal.…”

Section: Introductionmentioning

confidence: 99%

Equivalent time active cavitation imaging

et al. 2021

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Rationale. Despite the development of a large number of neurologically active drugs, brain diseases are difficult to treat due to the inability of many drugs to penetrate the blood-brain barrier. High-intensity focused ultrasound (HIFU) blood-brain barrier opening in a site-specific manner could significantly expand the spectrum of available drug treatments. However, without monitoring, brain damage and off-target effects can occur during these treatments. While some methods can monitor inertial cavitation, temperature increase, or passively monitor cavitation events, to the best of our knowledge none of them can actively and spatiotemporally map the HIFU pressure field during treatment. Methods. Here we detail the development of a novel ultrasound imaging modality called equivalent time active cavitation imaging (ETACI) capable of characterizing the HIFU pressure field through stable cavitation events across the field of view with an ultrafast active imaging setup. This work introduces (1) a novel plane wave sequence whose transmit delays increase linearly with transmit events enabling the sampling of high-frequency cavitation events, and (2) an algorithm allowing the processing of the microbubble signal for pressure field mapping. The pressure measurements with our modality were first carried out in vitro for hydrophone comparison and then in vivo during blood-brain barrier opening treatment in mice. Results. This study demonstrates the capability of ETACI to spatiotemporally characterize a modulation pressure field with an active imaging setup. The resulting pressure field mapping reveals a good correlation with hydrophone measurements. Further results iareprovided experimentally in vivo with promising results. Conclusion. This proof of concept establishes the first steps towards a novel ultrasound modality for monitoring focused ultrasound blood-brain barrier opening, allowing new possibilities for a safe and precise monitoring method.

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Covert cavitation: Spectral peak suppression in the acoustic emissions from spatially configured nucleations

Cited by 10 publications

References 10 publications

Validity of the Keller-Miksis equation for “non-stable” cavitation and the acoustic emissions generated

Validity of the Keller-Miksis equation for “non-stable” cavitation and the acoustic emissions generated

Theoretical analysis and experimental verification of spatial coherence of acoustic cavitation noise from bubble clusters under ultrasonic horn

Equivalent time active cavitation imaging

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