Cover Picture: Macromol. Rapid Commun. 6/2006

Sugawara, Ayae; Yamane, Setsuko; Akiyoshi, Kazunari

doi:10.1002/marc.200690008

Cited by 7 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 nm that act as templates for CaP formation (Figure 4). [37] The nanogel particles are efficient templates for the fabrication of CaP/ polymer hybrid nanoparticles with a high colloidal stability. Furthermore, the nanogel particles can also be adsorbed on liposomes and act as templates for CaP/ organic hybrid materials with a hierarchical order.…”

Section: Nanogelsmentioning

confidence: 99%

“…This effect can be assigned to the presence of nanometer-sized gel particles. In the former case, [37] the gel is formed by the amphiphilic sugar/cholesterol copolymer. In the latter case, [82] the degree of protonation can be used as a control parameter to adjust the behavior of the PEI template: at low pH, PEI is water soluble, but at pH 8, where the experiments were conducted, the degree of protonation is only ca.…”

Section: Nanogelsmentioning

confidence: 99%

“…[7,8,10,11,13,16,18,[29][30][31][32][33][34][35][36][37] Other approaches towards advanced calcium phosphate/ organic hybrid materials include the mineralization of insoluble scaffolds or the mineralization in hydrogels.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Schweizer

Taubert

2007

Macromolecular Bioscience

102

111

View full text Add to dashboard Cite

Nowadays, the majority of the commercially available calcium phosphate materials is fabricated by 'classical' materials science approaches, i.e., from rather poorly defined slurries or from organic solvents, often at high temperatures and pressures. Bioinspired precipitation of inorganics with (polymeric) additives from aqueous solution, on the other hand, enables the synthesis of intriguing inorganic or organic/inorganic materials that are often much more closely related to biological structures. This article discusses approaches for the fabrication of bio-inspired calcium phosphate hybrid materials by precipitation from aqueous solution. The article focuses on polymers and related self-assembling structures for the design of CaP/organic hybrids and pure CaP with crystal structures and morphologies regulated by the respective additive.

show abstract

Section: Nanogelsmentioning

confidence: 99%

Section: Nanogelsmentioning

confidence: 99%

See 1 more Smart Citation

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Schweizer

Taubert

2007

Macromolecular Bioscience

102

111

View full text Add to dashboard Cite

show abstract

“…Other conceptual approaches where hybrid calcium phosphate nanoparticles were synthesized employing organic additives or templates such as surfactants, [12][13][14] liposomes, [15,16] block copolymers, [17,18] self-associated nanogels, [19] supramolecular hydrogels, [20] emulsions, and microemulsions [21][22][23] have been reported. Due to the feasibility to control shape, size, crystal structure, and orientation, the organization of inorganic colloids in polymeric matrices has made biomimetic approaches being intensively explored.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Hydroxyapatite Crystallization in Gelatin Nanoparticles Synthesized Using a Miniemulsion Process

Ethirajan

Ziener

Chuvilin

et al. 2008

Adv Funct Materials

View full text Add to dashboard Cite

Here, we report a novel biomimetic strategy to synthesize hydroxyapatite (HAP) inside of crosslinked gelatin nanoparticles, which serve as a nanoenvironment for crystal growth in the aqueous phase. The synthesis of gelatin nanoparticles with the inverse miniemulsion technique is very intriguing because of the flexibility offered by the technique in tailoring the properties of the gelatin nanoparticles. It can be shown that the nanoenvironment promotes a different growth environment for the crystal because of the confinement inside the particle. The formation of HAP inside the particles follows Ostwald's rule of stages. At first an amorphous phase is formed, which itself has a great potential to be used as a resorbable bone substitute. This further transforms into single crystalline HAP via an octacalcium phosphate intermediate. The solution‐mediated transformation into the HAP phase without any calcination step is studied in detail using transmission electron microscopy (TEM) and X‐ray diffraction (XRD) measurements.

show abstract

“…30 nm) in solution ( Figure 4A). 39,40 The formation of hybrids, consisting of nanogels with calcium phosphate, may provide more stable DDS materials with controlled release properties. However, one of the drawbacks of calcium phosphateCHP nanogel hybrid materials is that we only obtained amorphous or low-crystalline calcium phosphate as an inorganic component and could barely control the crystallinity.…”

Section: ç Introductionmentioning

confidence: 99%

Self-assembled Nanogel Engineering for Advanced Biomedical Technology

Sasaki

Akiyoshi

2012

Chemistry Letters

Self Cite

View full text Add to dashboard Cite

Nanogels are polymer nanoparticles with three-dimensional networks. Recently, various nanogels have been designed, with a particular focus on biomedical applications. In this review, we describe recent progress in the synthesis of functional nanogels by self-assembly of associating polymers and nanogel engineering for advanced biomedical technology including regenerative medicine and drug delivery systems. Ç IntroductionLiving systems, for example biomembranes which are selforganized assemblies of proteins and lipids, reveal sophisticated biological functions such as signal transduction, energy production, and cellular communication. The concept of supramolecular assembly of biocomponents such as lipids, proteins, nucleic acids, and polysaccharides is central to bottom-up design of advanced biomaterials. For example, molecular organization based on supramolecular assembly enables fabrication of not only materials with well-controllable molecular orientation and arrangement but mechanically controlled nanomaterials and nanosystems 1 or self-assembled micro-and nanoshells for drug delivery applications. Recently, we have proposed nanogel engineering, which involves design of self-assembled nanogel and the construction of functional hierarchical gels or interfaces through their bottomup assembly of nanogels as building units. The bottom-up nanogel engineering provides a new paradigm for development of hydrogel biomaterials with well-organized three-dimensional structures, multiple functions, sensitivity to a range of different stimuli, and programmed responses that can be controlled temporally and spatially. Nanogels are nanometer-sized hydrogel nanoparticles (<100 nm) with three-dimensional networks of crosslinked polymer chains. They have attracted growing interest over the last several years due to their potential for biomedical applications, such as drug delivery system (DDS) and bioimaging.3 Usual polymer nanoparticles, such as nanospheres, have a densely packed polymer inside core structure. In contrast, nanogels are able to stably trap bioactive compounds such as drugs, proteins, and DNA/RNA inside their nanospace with polymer networks. Moreover, nanogels show a rapid response to microenvironmental factors such as temperature and pH because of their nanoscale dimensions. These properties are useful for the controlled release of bioactive compounds.Nanogels have been prepared using various methods, which can be classified into two categories according to their crosslinking structure: chemically (covalent) crosslinked nanogels which form crosslinking points by covalent bonds and physically crosslinked nanogels with noncovalent bonds (such as hydrogen bonds), electrostatic and hydrophobic interactions. 4 Typically, chemically crosslinked nanogels are synthesized under dilute conditions by a crosslinking reaction of polymers modified with reactive groups, such as vinyl and thiol groups. Nano-or microemulsion polymerization methods are often used to obtain nanogels with a well-controlled size.A variety of...

show abstract

Cover Picture: Macromol. Rapid Commun. 6/2006

Cited by 7 publications

References 0 publications

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Biomimetic Hydroxyapatite Crystallization in Gelatin Nanoparticles Synthesized Using a Miniemulsion Process

Self-assembled Nanogel Engineering for Advanced Biomedical Technology

Contact Info

Product

Resources

About