Cover Picture: Eur. J. Immunol. 2/11

Abstract

The cover image of this issue consists of the immunohistochemical staining of μ‐calpain in a healthy human kidney and is taken from Letavernier et al. (pp. 473–484). In this article, the authors analyse the role of calpains in acute allograft rejection. The authors demonstrate that μ‐calpain expression is increased in human transplant kidneys undergoing acute or chronic rejection, mainly in infiltrating T cells. The authors further show that calpain inhibition delays allograft rejection. Interestingly, this delay in allograft rejection is associated with a limitation in allograft infiltration by T cells that is due to the slowing down in T‐cell migration rather than proliferation.

Selenoprotein K Is a Novel Target of m-Calpain, and Cleavage Is Regulated by Toll-like Receptor-induced Calpastatin in Macrophages

“…Both have been shown to be important for cellular migration, including immune cell chemotaxis (13)(14)(15). Subcellular localization is also similar with SelK localized to ER membranes, where the calpain/calpastatin network is operable.…”