Cover Picture: En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase‐2 as a Target for Kunitz‐Type Inhibitors (ChemBioChem 7/2016)
Abstract:The cover picture shows the proposed regulatory mechanism of the type II transmembrane serine protease matriptase‐2 predominantly expressed at the surface of hepatocytes. Human matriptase‐2 is a critical stimulator of iron absorption by negatively regulating hepcidin, the key hormone of iron homeostasis that controls dietary iron uptake and the release of iron from macrophages and hepatocytes. This involves the BMP/SMAD signalling pathway through cleavage of the BMP co‐receptor hemojuvelin (HJV). As a negative… Show more
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