Cover Image, Volume 527, Issue 18

Diniz, Giovanne B.; Battagello, Daniella S.; Cherubini, Pedro M.; Reyes-Mendoza, Julio; Luna‐Illades, Cesar; Klein, Marianne; Motta-Teixeira, Lívia Clemente; Sita, Luciane V.; Miranda‐Anaya, Manuel; Morales, Teresa; Bittencourt, Jackson C.

doi:10.1002/cne.24781

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“…Our findings are also relevant because the expression of nicotine sensitization during drug withdrawal is viewed as a behavioral correlate of the incubation of drug craving, a key diagnostic symptom of TUD and other forms of substance use disorders (American Psychiatric Association, 2022;Lu et al, 2004;Shaham et al, 2003). Anatomically, MCH neurons project to both the nucleus accumbens and the ventral tegmental area (Diniz et al, 2019), indicating that MCH modulates motivated behaviors regulated by the mesolimbic system, the primary circuit regulating reward-related behavior. There is increasing evidence for this hypothesis.…”

Section: Neurobehavioral Interactions Of Mch Function and Effects Of ...mentioning

confidence: 76%

“…Anatomically, MCH neurons project to both the nucleus accumbens and the ventral tegmental area (Diniz et al, 2019), indicating that MCH modulates motivated behaviors regulated by the MCH antagonism and nicotine locomotion Page 21 mesolimbic system, the primary circuit regulating reward-related behavior. There is increasing evidence for this hypothesis.…”

Section: Neurobehavioral Interactions Of Mch Function and Effects Of ...mentioning

confidence: 99%

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Melanin-concentrating hormone receptor antagonism differentially attenuates nicotine experience-dependent locomotor behavior in female and male rats

Kuebler,

Liu,

Bueno Álvarez

et al. 2023

Preprint

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Nicotine is a significant public health concern because it is the primary pharmacological agent in tobacco use disorder. One neural system that has been implicated in the symptoms of several substance use disorders is the melanin-concentrating hormone (MCH) system. MCH regulates various motivated behaviors depending on sex, yet little is known of how this interaction affects experience with drugs of abuse, particularly nicotine. The goal of this study was to determine the effect of MCH receptor antagonism on experience-dependent nicotine-induced locomotion after chronic exposure. Adult female and male Wistar rats were given saline then cumulative doses of nicotine (0.1, 0.32, 0.56, and 1.0 mg/kg) intraperitoneally to determine the acute effects of nicotine (day 1). Next, rats were treated with 1.0 mg/kg nicotine for 6 days, given an identical series of cumulative doses (day 8), and then kept in a drug-free state for 6 days. On day 15, rats were pretreated with vehicle or the MCH receptor antagonist GW803430 (10 or 30 mg/kg) before another series of cumulative doses to assess response to chronic nicotine. After vehicle, male rats increased nicotine locomotor activation from day 1 to day 15 while female rats showed a more complex pattern of responses. The lower dose of GW803430 decreased locomotion compared to vehicle in females, while the higher dose decreased locomotion in males. Both sexes showed nicotine dose-dependent effects of GW803430, strongest at lower doses of nicotine. Controlling for sex-based locomotor differences revealed that females are more sensitive to GW803430. The high dose of GW803430 also decreased saline locomotion in males. Together, the results of our study suggest that MCH is involved in the neurobehavioral response to chronic nicotine exposure, and that MCH regulates these nicotine behavioral symptoms differently across sex.

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Section: Neurobehavioral Interactions Of Mch Function and Effects Of ...mentioning

confidence: 76%

Section: Neurobehavioral Interactions Of Mch Function and Effects Of ...mentioning

confidence: 99%

Melanin-concentrating hormone receptor antagonism differentially attenuates nicotine experience-dependent locomotor behavior in female and male rats

Kuebler,

Liu,

Bueno Álvarez

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Cover Image, Volume 527, Issue 18

Abstract: The cover image is based on the Original Article Melanin‐concentrating hormone peptidergic system: comparative morphology between muroid species by Jackson C. Bittencourt et al., https://doi.org/10.1002/cne.24723.

Cited by 1 publication

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Melanin-concentrating hormone receptor antagonism differentially attenuates nicotine experience-dependent locomotor behavior in female and male rats

Melanin-concentrating hormone receptor antagonism differentially attenuates nicotine experience-dependent locomotor behavior in female and male rats

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