Cover Image Volume 39, Issue 9

Muñoz‐Carrillo, José Luis; Contreras-Cordero, Juan Francisco; Muñoz-López, J. L.; Maldonado-Tapia, Claudia; Muñoz-Escobedo, José Jesús; Moreno-García, María Alejandra

doi:10.1111/pim.12457

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have shown that Th1 cytokines, such as IL-12, INF-γ, IL-1β, and TNF-α are much more abundant in the early stages of intestinal infection by T. spiralis [63,[67][68][69]. Inflammatory mediators, such as prostaglandin E2 (PGE2) and nitric oxide (NO), as well as the production of Th1 cytokines, such as, IL-12, INF-γ, IL-1β and TNF-α, were found to be produced in greater amounts during the intestinal phase of the T. spiralis infection, which was linked to an increased number of eosinophils and the development of intestinal pathology [64,70]. This suggested that T. spiralis infection induced an increase of small intestine mucosal immune cells and a mixed Th1/Th2 phenotype with a predominance of Th2 response at the early stage of infection.…”

Section: Plos Pathogensmentioning

confidence: 99%

Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice

Sun,

Hao,

et al. 2024

PLoS Pathog

View full text Add to dashboard Cite

The hygiene hypothesis proposes that decreased exposure to infectious agents in developed countries may contribute to the development of allergic and autoimmune diseases. Trichinella spiralis, a parasitic roundworm, causes trichinellosis, also known as trichinosis, in humans. T. spiralis had many hosts, and almost any mammal could become infected. Adult worms lived in the small intestine, while the larvae lived in muscle cells of the same mammal. T. spiralis was a significant public health threat because it could cause severe illness and even death in humans who eat undercooked or raw meat containing the parasite. The complex interactions between gastrointestinal helminths, gut microbiota, and the host immune system present a challenge for researchers. Two groups of mice were infected with T. spiralis vs uninfected control, and the experiment was conducted over 60 days. The 16S rRNA gene sequences and untargeted LC/MS-based metabolomics of fecal and serum samples, respectively, from different stages of development of the Trichinella spiralis-mouse model, were examined in this study. Gut microbiota alterations and metabolic activity accompanied by parasite-induced immunomodulation were detected. The inflammation parameters of the duodenum (villus/crypt ratio, goblet cell number and size, and histological score) were involved in active inflammation and oxidative metabolite profiles. These profiles included increased biosynthesis of phenylalanine, tyrosine, and tryptophan while decreasing cholesterol metabolism and primary and secondary bile acid biosynthesis. These disrupted metabolisms adapted to infection stress during the enteral and parenteral phases and then return to homeostasis during the encapsulated phase. There was a shift from an abundance of Bacteroides in the parenteral phase to an abundance of probiotic Lactobacillus and Treg-associated-Clostridia in the encapsulated phase. Th2 immune response (IL-4/IL-5/IL-13), lamina propria Treg, and immune hyporesponsiveness metabolic pathways (decreased tropane, piperidine and pyridine alkaloid biosynthesis and biosynthesis of alkaloids derived from ornithine, lysine, and nicotinic acid) were all altered. These findings enhanced our understanding of gut microbiota and metabolic profiles of Trichinella -infected mice, which could be a driving force in parasite-shaping immune system maintenance.

show abstract

Section: Plos Pathogensmentioning

confidence: 99%

Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice

Sun,

Hao,

et al. 2024

PLoS Pathog

View full text Add to dashboard Cite

show abstract

“…For example, Trichinella spiralis larvae group (TSL-1) antigens induce the DCs maturation [92], leading to the expression of MHC II [93,94], promoting the development of a Th1 type cellular immune response [95]. Several studies, both in vitro and in vivo, have shown that during the early stage of intestinal infection by T. spiralis there is a significant increase of Th1 cytokines such as IL-12 [96,97], INF-γ [95][96][97][98], IL-1β [97][98][99] and TNF-α [96,97,100]. It is possible that this Th1 response is mediated through the TLR-4 activation in DCs by TSL-1, through the signaling pathway TLR4/MyD88/NF-κB [101,102].…”

Section: Parasitic Helminth Infectionsmentioning

confidence: 99%

Role of Dendritic Cells in Pathogen Infections: A Current Perspective

Muñoz‐Carrillo¹,

Contreras-Cordero²,

Gutiérrez-Coronado³

et al. 2021

Cell Interaction - Molecular and Immunological Basis for Disease Management

View full text Add to dashboard Cite

Dendritic cells (DC) represent an important link between innate and adaptive immunity, which play an important role during the immune response against pathogens. There are several populations and subpopulations of DC, but mainly two subpopulations are characterized: the classic DC specialized in the processing and presentation of the antigen; and the plasmacytoid DC that have a high phagocytic activity and capacity for the production of cytokines. This chapter aims to present the current aspects related to the most relevant characteristics and functions of DC, as well as their role in host defense against infections by viruses, parasites, bacteria, and fungi.

show abstract

“…Infective larvae of T. spiralis. Photomicrograph of infective larvae of T. spiralis, from artificial digestion, observed at a 10Â objective under the light optical microscope [10].…”

Section: Epidemiological Aspects Of Trichinellosismentioning

confidence: 99%

Current Aspects in Trichinellosis

Muñoz‐Carrillo¹,

Maldonado-Tapia²,

Luna³

et al. 2019

Parasites and Parasitic Diseases

View full text Add to dashboard Cite

Currently, it is estimated that more than 11 million humans in the world are infected by helminth parasites of Trichinella species, mainly by Trichinella spiralis (T. spiralis), responsible for causing Trichinellosis disease in both animals and humans. Trichinellosis is a cosmopolitan parasitic zoonotic disease, which has direct relevance to human and animal health, because it presents a constant and important challenge to the host's immune system, especially through the intestinal tract. Currently, there is an intense investigation of new strategies in pharmacotherapy and immunotherapy against infection by Trichinella spiralis. In this chapter, we will present the most current aspects of biology, epidemiology, immunology, clinicopathology, pharmacotherapy and immunotherapy in Trichinellosis.

show abstract

Cover Image Volume 39, Issue 9

Abstract: The cover image, by J. L. Muñoz‐Carrillo et al., is based on the Original Article Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection, DOI: .

Cited by 3 publications

References 0 publications

Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice

Trichinella spiralis -induced immunomodulation signatures on gut microbiota and metabolic pathways in mice

Role of Dendritic Cells in Pathogen Infections: A Current Perspective

Current Aspects in Trichinellosis

Contact Info

Product

Resources

About