Cover Feature: Surfactant‐Assisted Purification of Hydrophobic DNA Nanostructures (ChemBioChem 4/2023)

Abstract

This cover picture shows how the aggregation of modified DNA nanostructures can be prevented during their purification procedure. In the article by S. M. Nomura and Y. Sato et al., cholesterol‐modified DNA nanostructures are purified by a novel surfactant‐assisted gel extraction method, in which the addition of sodium cholate to the sample solution before structure folding prevented the formation of aggregates. The purified structures retain the ability to attach to lipid vesicle membranes. More information can be found in the Research Article by S. Iwabuchi, S. M. Nomura, Y. Sato.

Artificial Molecular Systems for Complex Functions Based on DNA Nanotechnology and Cell‐Sized Lipid Vesicles

“…Expanding this approach, a surfactant-assisted purification method for cholesterol-modified nanopores was developed. [26] Adding sodium cholate, an anionic surfactant, to the sample solution before the nanopore folding prevented aggregation, which allowed purification of the structure by gel extraction. The purified structures retain the binding ability onto GUV surfaces.…”