Cover Feature: Structural Effects of Fusicoccin upon Upregulation of 14‐3‐3‐Phospholigand Interaction and Cytotoxic Activity (Chem. Eur. J. 60/2018)

Abstract

Fusicoccin, a phytotoxic diterpene glucoside, was converted to a series of antiproliferative agents for tumor cells by removing 12‐hydroxyl group semi‐synthetically. These compounds were shown to upregulate interaction of 14‐3‐3 and a phospholigand in a sequence‐specific manner. More information can be found in the Full Paper by J. Ohkanda et al. on page 16066.