Cover Feature: Metal Exchange in the Interprotein Zn^II‐Binding Site of the Rad50 Hook Domain: Structural Insights into Cd^II‐Induced DNA‐Repair Inhibition (Chem. Eur. J. 15/2020)

Abstract

An extreme affinity of CdII towards the interprotein Rad50 zinc hook domain visualizes how a ZnII‐to‐CdII swap can affect the target protein's status and thus illuminate the molecular basis of CdII‐induced genotoxicity. This work showed that CdII binding to the interprotein Rad50 hook domain induces a two‐orders‐of‐magnitude stabilization effect, which disrupts the overall assembly of the domain and may cause dysfunction of the MRN/X complex. More information can be found in the Full Paper by A. Krężel, et al. page 3297.