Cover Feature: LEGO‐Inspired Drug Design: Unveiling a Class of Benzo[d]thiazoles Containing a 3,4‐Dihydroxyphenyl Moiety as Plasma Membrane H⁺‐ATPase Inhibitors (ChemMedChem 1/2018)

Abstract

The Cover Feature shows a rational procedure for assembling privileged molecular fragments (like playing with LEGO bricks) to obtain hit structures. We have invented a novel procedure for targeting biological macromolecules possessing a binding site with a poorly known topography. We have coined this protocol HFSA (Hypothesis‐based Fragment Selection and Assembly). The feasibility of the method has been demonstrated by construction of inhibitors of fungal plasma membrane H+‐ATPase (Pma1p). More information can be found in the Full Paper by Søren B. Christensen, John Nielsen et al. on page 37 in Issue 1, 2018 (DOI: 10.1002/cmdc.201700635).