Cover Feature: Irreversible Inhibition of IspG, a Target for the Development of New Antimicrobials, by a 2‐Vinyl Analogue of its MEcPP Substrate (Chem. Eur. J. 30/2022)

Abstract

The rational design of a substrate analogue has afforded the first irreversible inhibitor of an IspG enzyme, a target for the development of new drugs to fight antimicrobial resistance. Inspired by the structural features of the natural substrate and by mechanistic aspects, we introduced a vinyl substituent to generate conjugated species during enzyme catalysis. Inhibition might occur through covalent interaction at the catalytic site. More information can be found in the Research Article by J.‐B. Behr, M. Seemann, and co‐workers (DOI: 10.1002/chem.202200241).