Cover Feature: Enantiodivergent Chemoenzymatic Dynamic Kinetic Resolution: Conversion of Racemic Propargyl Alcohols into Both Enantiomers (Chem. Eur. J. 60/2022)

Abstract

A method for enantiodivergent production of S and R propargylic alcohols from their racemates by using commercial lipase‐based dynamic kinetic resolution achieves quantitative conversion of the racemates into optically pure substances. The right and left hands, wearing jeweled rings indicating individual reaction steps, lead to opposite enantioselection, producing S and R alcohols, respectively. The order of the jewels is key to the enantioswitch. More information can be found in the Research Article by S. Akai and co‐workers (DOI: 10.1002/chem.202202437).

Nucleophilic Deprotection of <i>p</i>-Methoxybenzyl Ethers Using Heterogeneous Oxovanadium Catalyst

“…1c). During the course of our continuous research on V-MPS4 catalysis, [6][7][8][9][10] we realized that V-MPS4 could also catalyze the C-O bond cleavage of reactive ethers such as p-methoxybenzyl (PMB) [also known as p-methoxyphenylmethyl (MPM)] ethers. Based on this finding, we report herein the V-MPS4-catalyzed nucleophilic deprotection of PMB ethers to furnish alcohols (Fig.…”