Cover Feature: A Facile Method for the Separation of Methionine Sulfoxide Diastereomers, Structural Assignment, and DFT Analysis (Chem. Eur. J. 20/2020)

Abstract

Methionine sulfoxide chirality is emerging as an important signaling node in redox biology, regulating cellular processes as pivotal as actin polymerization. Research is hampered by lack of methods to obtain pure methionine sulfoxide diastereomers. The present contribution provides a scalable process, which, using supercritical CO2, allows rapid access to both diastereomers in purities of 99.9 % and should open the road the systematic chemical biology studies of methionine redox processes. More information can be found in the Communication by J. A. Raskatov et al. on page 4467.