Cover Feature: A Designed Enzyme Promotes Selective Post‐translational Acylation (ChemBioChem 15/2018)

Abstract

The cover feature picture shows how a computationally designed allosterically regulated esterase CaM M144H, a derivative of AlleyCatE, can recognize and specifically post‐translationally modify helical domains (highlighted in green) in calmodulin‐binding proteins with an unnatural tag providing structural and functional insight into protein–protein interactions. More information can be found in the communication by O. V. Makhlynets, I. V. Korendovych, et al. on page 1605 in Issue 15, 2018 (DOI: 10.1002/cbic.201800196).