Covalently functionalized uniform amino-silica nanoparticles. Synthesis and validation of amine group accessibility and stability

Miller, Peter J.; Shantz, Daniel F.

doi:10.1039/c9na00772e

Cited by 14 publications

(13 citation statements)

References 62 publications

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“…It can be observed that some of the s-f-nSiO 2 particles have larger size compared to the pristine nSiO 2 particles due to the formation of the polymeric layer of silane from APTES caused by residual water as the solvent and silane was not rigorously dried. 29 The size of nSiO 2 particles is found in the range of 10 to 15 nm (as illustrated in Figure 1(a)), whereas, 10 to 20 nm for s-f-nSiO 2 particles (as illustrated in Figure 1(b)).…”

Section: Methodsmentioning

confidence: 95%

Impact behavior of aminosilane functionalized nanosilica based shear thickening fluid impregnated Kevlar fabrics

Katiyar

Nandi

Prasad

2021

J of Applied Polymer Sci

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In the present work, two types of shear thickening fluids have been synthesized by using neat and aminosilane functionalized silica nanoparticles and their viscosity curves have been obtained by the rheometer. Based on the values of peak viscosity of synthesized shear thickening fluids, the surface functionalized nanosilica based shear thickening fluid has been chosen as a best candidate due to the high viscosity for impregnation into the neat Kevlar of different layers viz. four (04) and eight (08) layers for velocity impact study. The experimental investigations reveal high energy absorption of shear thickening fluid impregnated Kevlar as compared to the neat Kevlar. The maximum energy absorption 62 J is achieved corresponding to the initial velocity 154 mÁs −1 for 08 layers shear thickening fluid impregnated Kevlar specimen. The data have also been analytically determined and validated with the experimental data. The experimental data have good agreement with the analytical data within the accuracy of around 15 to 20%. The present findings can have significant inferences towards the fabrication of shear thickening fluids using nanomaterials for numerous applications such as soft armors, dampers, nanofinishing and so forth.

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Section: Methodsmentioning

confidence: 95%

Impact behavior of aminosilane functionalized nanosilica based shear thickening fluid impregnated Kevlar fabrics

Katiyar

Nandi

Prasad

2021

J of Applied Polymer Sci

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“…[114]. Copyright 2015, American Chemical Society in comparison to NMR measurements [121], and to study the FG density and colloidal stability of surface functionalized silica NP over a period of time of 30 days [122]. Sun et al compared the quantification potential of two optical assays (Ninhydrin and 4-nitrobenzaldehyde) with 19 F solid state NMR measurements to quantify FG on amino-modified silica NP of different sizes (see Fig.…”

Section: Activatable ("Turn-on") and Chromogenic ("Chameleon") Reporter Dyesmentioning

confidence: 99%

“…As the Ninhydrin reaction is an equilibrium reaction, Ruhemann’s Purple is continuously generated in the presence of primary amino groups reacting to aldehyde functionalities, which reduces the impact of steric crowding of multiple Ninhydrin molecules occupying neighboring FG. Ninhydrin was, e.g., used to monitor the reproducibility of silica particle synthesis and their modification with APTES in comparison to NMR measurements [ 121 ], and to study the FG density and colloidal stability of surface functionalized silica NP over a period of time of 30 days [ 122 ]. Sun et al compared the quantification potential of two optical assays (Ninhydrin and 4-nitrobenzaldehyde) with 19 F solid state NMR measurements to quantify FG on amino-modified silica NP of different sizes (see Fig.…”

Section: Fg Quantification With Photometric and Fluorometric Assays And Different Optical Reportersmentioning

confidence: 99%

Analyzing the surface of functional nanomaterials—how to quantify the total and derivatizable number of functional groups and ligands

et al. 2021

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Functional nanomaterials (NM) of different size, shape, chemical composition, and surface chemistry are of increasing relevance for many key technologies of the twenty-first century. This includes polymer and silica or silica-coated nanoparticles (NP) with covalently bound surface groups, semiconductor quantum dots (QD), metal and metal oxide NP, and lanthanide-based NP with coordinatively or electrostatically bound ligands, as well as surface-coated nanostructures like micellar encapsulated NP. The surface chemistry can significantly affect the physicochemical properties of NM, their charge, their processability and performance, as well as their impact on human health and the environment. Thus, analytical methods for the characterization of NM surface chemistry regarding chemical identification, quantification, and accessibility of functional groups (FG) and surface ligands bearing such FG are of increasing importance for quality control of NM synthesis up to nanosafety. Here, we provide an overview of analytical methods for FG analysis and quantification with special emphasis on bioanalytically relevant FG broadly utilized for the covalent attachment of biomolecules like proteins, peptides, and oligonucleotides and address method- and material-related challenges and limitations. Analytical techniques reviewed include electrochemical titration methods, optical assays, nuclear magnetic resonance and vibrational spectroscopy, as well as X-ray based and thermal analysis methods, covering the last 5–10 years. Criteria for method classification and evaluation include the need for a signal-generating label, provision of either the total or derivatizable number of FG, need for expensive instrumentation, and suitability for process and production control during NM synthesis and functionalization. Graphical abstract

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“…To overcome the toxicity issue, attention was directed toward NP-oxides as a more safer and effective alternative 28 . In the same regard, NPs surface modi cation was also proposed to increase the NPs applicability range with lower side toxicity 29,30 . Recently, growing interest in nanoparticles surface functionalization with different functional groups and bio-macules as amino acids, short peptide, and proteins toward new applications was intensively reported 29,31 .…”

Section: Introductionmentioning

confidence: 99%

“…In the same regard, NPs surface modi cation was also proposed to increase the NPs applicability range with lower side toxicity 29,30 . Recently, growing interest in nanoparticles surface functionalization with different functional groups and bio-macules as amino acids, short peptide, and proteins toward new applications was intensively reported 29,31 . Owing to the large surface-to-mass ratio, NPs adsorb these biomolecules on their large surface area in corona-like structure through Van der Waals forces revealing new biological activity 32 .…”

Section: Introductionmentioning

confidence: 99%

Novel Nanocombinations of L-tryptophan and L-cysteine: Preparation, Characterization and Their Applications for Dye Decolorization, Antimicrobial and Anticancer Activities

Abd-Elhamid

El‐Gendi

Abdallah

et al. 2021

Preprint

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Tungsten oxide WO3 nanoparticles (NPs) were prepared in a form of nanosheets with a homogeneous size and dimensions in one step through acid precipitation using a cation exchange column. The resulting WO3 nanosheets surface was decorated with one of the two amino acids (AAs) L-tryptophan (Trp) or L-cysteine (Cys) for their dye removal, antimicrobial, and antitumor activities. A noticeable improvement in the biological activity of WO3 NPs was detected upon amino acid modification compared to the original WO3. The prepared WO3-Trp and WO3-Cys exhibited strong dye removal activity toward methylene blue and safranin dyes with complete dye removal (100%) after 6 h. WO3-Cys NPs and WO3-Trp NPs revealed higher broad-spectrum antibacterial activity toward both G-ve and G+ve bacteria with strong antifungal activity toward Candida albicans. Anticancer results of the modified WO3-Cys and WO3-Trp NPs against various kinds of cancer cells including MCF-7, caco-2, and HepG-2 cells indicated that they have a potent effect in a dose-dependent manner with high selectivity to cancer cells and safety against normal cells. The expression levels of E2F2, Bcl-2 genes were found to be suppressed after treatment with both WO3-Cys and WO3-Trp NPs more than 5-FU-treated cells. While expression level of the p53 gene in all tested cells was evidently up-regulated after treatment by more than 5-8 folds as compared to untreated cells. The docking results confirmed the ability of both NPs to bind to P53 gene with relevant potency in binding to other tested gens and participation of cysteine SH-functional group in such interaction.

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Covalently functionalized uniform amino-silica nanoparticles. Synthesis and validation of amine group accessibility and stability

Abstract: This paper describes the synthesis and characterization of stable, 18 nm silica nanoparticles that are functionalized with amine groups.

Cited by 14 publications

References 62 publications

Impact behavior of aminosilane functionalized nanosilica based shear thickening fluid impregnated Kevlar fabrics

Impact behavior of aminosilane functionalized nanosilica based shear thickening fluid impregnated Kevlar fabrics

Analyzing the surface of functional nanomaterials—how to quantify the total and derivatizable number of functional groups and ligands

Novel Nanocombinations of L-tryptophan and L-cysteine: Preparation, Characterization and Their Applications for Dye Decolorization, Antimicrobial and Anticancer Activities

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