Covalent Organic Frameworks for Biomedical Applications

Abstract

Covalent organic frameworks (COFs) are porous organic polymeric materials that are composed of organic elements and linked together by the thermodynamically stable covalent bonds. The applications of COFs in energy sector and drug delivery are afforded because of the desirable properties of COFs, such as high stability, low density, large surface area, multidimensionality, porosity, and high‐ordered crystalline structure expanded. In this review COFs are reviewed, from the perspective of different types of reported COFs, different methods for their synthesis, and their potential applications in the biomedical field. The main goal of this review is to introduce COFs as a biomaterial and to identify specific advantages of different types of COFs that can be exploited for specialized biomedical applications, such as immune engineering.

Emerging porous organic polymers for biomedical applications

“…Consequently, an increasing number of examples using POPs for various biomedical applications have been reported. 84–91 Considering the rapid development in this emerging field, herein we present a comprehensive review to cover the recent advances of different types of POPs and their applications in diverse biomedical fields.…”

Metal-assisted synthesis of salen-based porous organic polymer for highly efficient fixation of CO2 into cyclic carbonates

“…As an emerging material platform, porous organic polymers (POPs) 36,37 have attracted a huge amount of interest in widespread applications, including gas storage and separation, 38,39 sensing, 40,41 drug delivery, 42,43 energy storage, 44,45 and heterogeneous catalysis, 9 because of their well-defined chemical structures, adjustable functions and compositions, large specific surface area, ordered pore size distribution, and high thermal stability.…”

A Ferrocene‐Functionalized Covalent Organic Framework for Enhancing Chemodynamic Therapy via Redox Dyshomeostasis

“…[ 28 ] More importantly, as a class of organic carriers, COFs provide an opportunity to controllably introduce metals into the materials as needed under the premise of ensuring the therapeutic effect, which may circumvent the potential physiological toxicity of metal‐rich inorganic materials. [ 29 ] Both advantages are highly beneficial for advancing preclinical and translational clinical studies of COFs; [ 30 ] however, to date, the potential of COF‐based nanomaterials for CDT has not been adequately exploited.…”