Covalent organic frameworks and electron mediator-based open circuit potential biosensor for<i>in vivo</i>electrochemical measurements

Su, Dan; Feng, Bingwei; Xu, Ping; Zeng, Qiang; Shan, Baixi; Song, Yonggui

doi:10.1039/c8ay01386a

Cited by 33 publications

(19 citation statements)

References 35 publications

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“…Su et al reported a COF‐based electronic media mediated open circuit potential biosensor (OCPS) consisting of a carbon fiber microelectrode (CFME) and an Ag/AgCl reference microelectrode for glucose detection . The authors used the previously reported 2D COF‐LZU1, prepared by the condensation of 1,3,5‐triformylbenzene and 1,4‐diaminobenzene for electrode construction.…”

Section: Enzyme Immobilization Into Covalent Organic Frameworkmentioning

confidence: 99%

Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

et al. 2020

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The development of efficient catalytic systems is a fundamental aspect for the straightforward production of chemicals. During the last years, covalent organic frameworks (COFs) emerged as an exciting class of organic nanoporous materials. Due to their pre‐designable structure, they can be prepared with distinct physicochemical characteristics, specific pore sizes, and tunable functional groups. Moreover, associated with their stability in different media, these materials are considered promising supports for enzyme immobilization. Herein, it is highlighted the recent literature of enzyme immobilization in COFs, the main immobilization strategies, and the catalytic applications of these composites.

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Section: Enzyme Immobilization Into Covalent Organic Frameworkmentioning

confidence: 99%

Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

et al. 2020

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“…Through design, the good matched pore size could impede the aggregation of enzymes and facilitate the rapid transportation of reagents at the same time [ 29 ]. There are also specific sites on the interface for weak interaction or covalent binding [ 30 , 31 ], so that the immobilization process varies with a practical need [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic COFs as satisfactory support for lipase immobilization and recovery to effectively achieve the production of biodiesel by maintenance of enzyme activity

Zhou

Cai

Xing

et al. 2021

Biotechnol Biofuels

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Background Production of biodiesel from renewable sources such as inedible vegetable oils by enzymatic catalysis has been a hotspot but remains a challenge on the efficient use of an enzyme. COFs (Covalent Organic Frameworks) with large surface area and porosity can be applied as ideal support to avoid aggregation of lipase and methanol. However, the naturally low density limits its application. In this work, we reported a facile synthesis of core–shell magnetic COF composite (Fe3O4@COF-OMe) to immobilize RML (Rhizomucor miehei lipase), to achieve its utilization in biodiesel production. Result This strategy gives extrinsic magnetic property, and the magnetic COFs is much heavier and could disperse in water medium well, facilitating the attachment with the enzyme. The resultant biocomposite exhibited an excellent capacity of RML due to its high surface area and fast response to the external magnetic field, as well as good chemical stability. The core–shell magnetic COF-OMe structure not only achieved highly efficient immobilization and recovery processes but also maintained the activity of lipase to a great extent. RML@Fe3O4@COF-OMe performed well in practical applications, while free lipase did not. The biocomposite successfully achieved the production of biodiesel from Jatropha curcas Oil with a yield of about 70% in the optimized conditions. Conclusion Magnetic COFs (Fe3O4@COF-OMe) for RML immobilization greatly improved catalytic performance in template reaction and biodiesel preparation. The magneticity makes it easily recovered and separated from the system. This first successful attempt of COFs-based immobilized enzyme broadened the prospect of biodiesel production by COFs with some inspiration.

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“…Through design, the good matched pore size could impede the aggregation of enzymes and facilitate the rapid transportation of reagents at the same time. 29 There are also speci c sites on the interface for weak interaction or covalent binding, 30,31 so that the immobilization process varies with a practical need. 32 Since Kandambeth et al reported the rst example to utilize COFs for enzyme immobilization, 33 a few COF-based immobilized enzymes are reported for applications, such as the kinetic resolution of secondary alcohols by Sun et al(TPB-DMTP-COF@Lipase PS) 34 and chiral separation by Zhang et al(lysozyme covalently immobilized on COF 1 ).…”

Section: Introductionmentioning

confidence: 99%

Magnetic COFs as Satisfied Support for Lipase Immobilization and Recovery to Effectively Achieve the Production of Biodiesel by Great Maintenance of Enzyme Activity

Zhou

Cai

Xing

et al. 2021

Preprint

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Background: Production of biodiesel from renewable sources such as inedible vegetable oils by enzymatic catalysis has been a hotspot but remains a challenge on the efficient use of an enzyme. COFs (Covalent Organic Frameworks) with large surface area and porosity can be applied as ideal support to avoid aggregation of lipase and methanol. However, the naturally low density limits its application. In this work, we reported a facile synthesis of core-shell magnetic COF composite (Fe3O4@COF-OMe) to immobilize RML (Rhizomucor miehei lipase), to achieve its utilization in biodiesel production.Result: This strategy gives extrinsic magnetic property, and the magnetic COFs is much heavier and could disperse in water medium well, facilitating the attachment with the enzyme. The resultant biocomposite exhibited an excellent capacity of RML due to its high surface area and fast response to the external magnetic field, as well as good chemical stability. The core-shell magnetic COF-OMe structure not only achieved highly efficient immobilization and recovery processes but also maintained the activity of lipase to a great extent. RML@Fe3O4@COF-OMe performed well in practical applications, while free lipase did not. The biocomposite successfully achieved the production of biodiesel from Jatropha curcas Oil with a yield of about 70% in the optimized conditions. Conclusion: Magnetic COFs (Fe3O4@COF-OMe) for RML immobilization greatly improved catalytic performance in template reaction and biodiesel preparation. The magneticity makes it easily recovered and separated from the system. This first successful attempt of COFs-based immobilized enzyme broadened the prospect of biodiesel production by COFs with some inspiration.

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Covalent organic frameworks and electron mediator-based open circuit potential biosensor forin vivoelectrochemical measurements

Abstract: Schematic illustration of the structure of GOD/DMFc/COF-LZU1/CFMEs and the analytical principles of OCPS.

Cited by 33 publications

References 35 publications

Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

Enzyme Immobilization in Covalent Organic Frameworks: Strategies and Applications in Biocatalysis

Magnetic COFs as satisfactory support for lipase immobilization and recovery to effectively achieve the production of biodiesel by maintenance of enzyme activity

Magnetic COFs as Satisfied Support for Lipase Immobilization and Recovery to Effectively Achieve the Production of Biodiesel by Great Maintenance of Enzyme Activity

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