Covalent Organic Framework-Based Assembly Systems for The Intracellular Delivery of Proteins: Opportunities and Challenges

Zhou, Shengnan; Hu, Danyou; Fang, Zhirui; Gao, Shan

doi:10.2217/nnm-2021-0062

Cited by 3 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COFs are typically composed of rigid, geometrically defined organic components that form solid, covalently bonded, planar, or three-dimensional crystal networks. The combination of high permanent porosity and specific surface area with high heat and chemical stability, crystallinity, and customizability makes COFs an ideal material candidate for a wide range of scientific applications. − …”

Section: Introductionmentioning

confidence: 99%

Characteristic Synthesis of a Covalent Organic Framework and Its Application in Multifunctional Tumor Therapy

Zhou

Meng

et al. 2021

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

For decades, covalent organic frameworks (COFs) have attracted wide biomedical interest due to their unique properties including ease of synthesis, porosity, and adjustable biocompatibility. Versatile COFs can easily encapsulate various therapeutic drugs due to their extremely high payload and porosity. COFs with abundant functional groups can be surface-modified to achieve active targeting and enhance biocompatibility. In this paper, the latest developments of COFs in the biomedical field are summarized. First, the classification and synthesis of COFs are discussed. Cancer diagnosis and treatment based on COFs are studied, and the advantages and limitations of each method are discussed. Second, the specific preparation methods to obtain specific therapeutic properties are summarized. Finally, based on the combination and modification of COFs with various components, this review system summarizes different combination therapies. In addition, the main challenges faced in COF research and prospects for applying COFs to cancer diagnosis and treatment are evaluated. This review provides enlightening insights into the interdisciplinary research on COFs and applications in biomedicine, which highlight the great expectations for their further clinical transformation.

show abstract

Section: Introductionmentioning

confidence: 99%

Characteristic Synthesis of a Covalent Organic Framework and Its Application in Multifunctional Tumor Therapy

Zhou

Meng

et al. 2021

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

show abstract

Design and synthesis of dual functional porphyrin-based COFs as highly selective adsorbent and photocatalyst

Wang²,

et al. 2023

Chemical Engineering Journal

View full text Add to dashboard Cite

Theranostics of Metal–Organic Frameworks: Image-Guided Nanomedicine for Clinical Translation

Mehata

Vikas

Viswanadh

et al. 2023

Nanomedicine (Lond.)

View full text Add to dashboard Cite

Metal–organic frameworks (MOFs)-based theranostic nanomedicine has demonstrated enormous potential for cancer diagnosis and therapy due to its versatile physiochemical properties, such as structural and morphological properties, specific cellular targeting, tunable pore and particle size, higher surface area, drug-loading capacity, biodegradability and biocompatibility. Notably, MOFs, loaded with diagnostic and therapeutic agents and functionalized with targeting moiety, are capable of catering to both targeted imaging and therapy simultaneously. Additionally, MOFs have demonstrated excellent potential in drug delivery, drug targeting, bioimaging, biosensing, biocatalysis and so on. However, major challenges associated with MOFs include improving their stability, biocompatibility and therapeutic efficacy and reducing the toxicity. This special report sheds light on the historical development, synthesis, recent advancements, toxicity and challenges associated with MOFs-based cancer nanotheranostics for their clinical translation.

show abstract

Covalent Organic Framework-Based Assembly Systems for The Intracellular Delivery of Proteins: Opportunities and Challenges

Cited by 3 publications

References 20 publications

Characteristic Synthesis of a Covalent Organic Framework and Its Application in Multifunctional Tumor Therapy

Characteristic Synthesis of a Covalent Organic Framework and Its Application in Multifunctional Tumor Therapy

Design and synthesis of dual functional porphyrin-based COFs as highly selective adsorbent and photocatalyst

Theranostics of Metal–Organic Frameworks: Image-Guided Nanomedicine for Clinical Translation

Contact Info

Product

Resources

About