“…In particular, electrophilic environmental chemicals should be given priority for evaluation not only because they are routinely and chronically exposed in daily life but also because they form protein adducts and disrupt the functions of proteins ( 78 , 79 ). We previously reported that 1,2-naphthoquinone, which is found in air pollutants such as particulate matter 2.5, activates EGFR via N -arylation and induces PI3K–Akt signaling ( 80 ). Our studies indicate that the disruption of signaling homeostasis by 1,2-naphthoquinone, MVK, and MVK analogs leads to adverse physiological effects and demonstrate the importance of protein adduct formation by environmental electrophiles as a model for exposome research.…”