Covalent diphenylalanine peptide nanotube conjugated to folic acid/magnetic nanoparticles for anti-cancer drug delivery

Emtiazi, Giti; Zohrabi, Tayebeh; Lee, Lai Yeng; Habibi, Neda; Zarrabi, Ali

doi:10.1016/j.jddst.2017.06.005

Cited by 33 publications

(17 citation statements)

References 25 publications

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“…At the same time, it is now known that the chirality of the initial molecules plays an important role in self-assembly processes [ 5 , 6 , 7 ]. All this is important both for our understanding of the basic principles of the emergence of life, and for numerous practical applications [ 5 , 6 , 7 ], including the new nanomaterials synthesis for nanoelectronics [ 3 , 8 , 9 ] and biomaterials for usage in biomedicine [ 10 , 11 ], including targeted drug delivery [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Structures and Properties of the Self-Assembling Diphenylalanine Peptide Nanotubes Containing Water Molecules: Modeling and Data Analysis

et al. 2020

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The structures and properties of the diphenylalanine (FF) peptide nanotubes (PNTs), both L-chiral and D-chiral (L-FF and D-FF) and empty and filled with water/ice clusters, are presented and analyzed. DFT (VASP) and semi-empirical calculations (HyperChem) to study these structural and physical properties of PNTs (including ferroelectric) were used. The results obtained show that after optimization the dipole moment and polarization of both chiral type L-FF and D-FF PNT and embedded water/ice cluster are enhanced; the water/ice cluster acquire the helix-like structure similar as L-FF and D-FF PNT. Ferroelectric properties of tubular water/ice helix-like cluster, obtained after optimization inside L-FF and D-FF PNT, as well of the total L-FF and D-FF PNT with embedded water/ice cluster, are discussed.

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Section: Introductionmentioning

confidence: 99%

Structures and Properties of the Self-Assembling Diphenylalanine Peptide Nanotubes Containing Water Molecules: Modeling and Data Analysis

et al. 2020

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“…Self-assembled nanotubes obtained for aggregation of unnatural fluorinated-peptides containing two aryl units were found able to penetrate the cultured primary human smooth muscle cells and to locate in their cytoplasmic/perinuclear region [29]. Successively, FF-micro and nanotubes, covalently conjugated to folic acid/magnetic nanoparticles (FA/MNPs), were also evaluated as a potential delivery systems of the anti-cancer therapeutic 5-fluorouracil (5-FU), and of the anti-inflammatory cargo flufenamic acid (FFA) [30].…”

Section: Peptide Self-assembled Nanostructuresmentioning

confidence: 99%

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

Tesauro¹,

Accardo²,

Diaferia³

et al. 2019

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190

137

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Peptides of natural and synthetic sources are compounds operating in a wide range of biological interactions. They play a key role in biotechnological applications as both therapeutic and diagnostic tools. They are easily synthesized thanks to solid-phase peptide devices where the amino acid sequence can be exactly selected at molecular levels, by tuning the basic units. Recently, peptides achieved resounding success in drug delivery and in nanomedicine smart applications. These applications are the most significant challenge of recent decades: they can selectively deliver drugs to only pathological tissues whilst saving the other districts of the body. This specific feature allows a reduction in the drug side effects and increases the drug efficacy. In this context, peptide-based aggregates present many advantages, including biocompatibility, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery. A dual behavior is observed: on the one hand they can fulfill a structural and bioactive role. In this review, we focus on the design and the characterization of drug delivery systems using peptide-based carriers; moreover, we will also highlight the peptide ability to self-assemble and to actively address nanosystems toward specific targets.

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“…The biological marker, rhodamine B, incorporated at the time of self-assembly, had the possibility to intercalate and showed its presence in the inner core to be accepted as intracellular drug delivery for hydrophilic molecules (Silva et al, 2013). These H-Phe-Phe-OH microtubes were further explored for delivering anti-cancer therapeutics, viz., 5-fluorouracil (5-FU) and anti-inflammatory cargo, flufenamic acid (FFA), by Emtiazi et al (2017) post-conjugation with folicacid and magnetic nanoparticles. These were found to show the potential as molecular carriers (Emtiazi et al, 2017).…”

Section: Dipeptides For Biologics Deliverymentioning

confidence: 99%

“…These H-Phe-Phe-OH microtubes were further explored for delivering anti-cancer therapeutics, viz., 5-fluorouracil (5-FU) and anti-inflammatory cargo, flufenamic acid (FFA), by Emtiazi et al (2017) post-conjugation with folicacid and magnetic nanoparticles. These were found to show the potential as molecular carriers (Emtiazi et al, 2017).…”

Section: Dipeptides For Biologics Deliverymentioning

confidence: 99%

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

Gupta

Singh

Sharma

et al. 2020

Front. Bioeng. Biotechnol.

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The translational therapies to promote interaction between cell and signal come with stringent eligibility criteria. The chemically defined, hierarchically organized, and simpler yet blessed with robust intermolecular association, the peptides, are privileged to make the cutoff for sensing the cell-signal for biologics delivery and tissue engineering. The signature service and insoluble network formation of the peptide self-assemblies as hydrogels have drawn a spell of research activity among the scientists all around the globe in the past decades. The therapeutic peptide market players are anticipating promising growth opportunities due to the ample technological advancements in this field. The presence of the other organic moieties, enzyme substrates and well-established protecting groups like Fmoc and Boc etc., bring the best of both worlds. Since the large sequences of peptides severely limit the purification and their isolation, this article reviews the account of last 5 years' efforts on novel approaches for formulation and development of single molecule amino acids, ultra-short peptide self-assemblies (di-and tri-peptides only) and their derivatives as drug/gene carriers and tissue-engineering systems.

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Covalent diphenylalanine peptide nanotube conjugated to folic acid/magnetic nanoparticles for anti-cancer drug delivery

Cited by 33 publications

References 25 publications

Structures and Properties of the Self-Assembling Diphenylalanine Peptide Nanotubes Containing Water Molecules: Modeling and Data Analysis

Structures and Properties of the Self-Assembling Diphenylalanine Peptide Nanotubes Containing Water Molecules: Modeling and Data Analysis

Peptide-Based Drug-Delivery Systems in Biotechnological Applications: Recent Advances and Perspectives

Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos

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