Covalent coating strategy for enhancing the biocompatibility and hemocompatibility of blood-contacting medical materials

Sheng, Kangjia; Gao, Yan; Bao, Tao; Wang, Sicen

doi:10.1016/j.pscia.2022.100001

Cited by 8 publications

(8 citation statements)

References 75 publications

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“…To assess the in vitro hemocompatibility of NMIC derivatives, tests were chosen with the help of which it is possible to assess the effect on the coagulation of whole blood and platelet-poor human plasma (BRT, APTT), as well as on the aggregation of human platelets and, indirectly (according to the degree of hemolysis), on the cell membrane of human erythrocytes [ 41 ]. Incubation in a blood/plasma test tube of compounds with anticoagulant activity (coagulation factor inhibitors or plasma coagulation factor inhibitors activators) leads to an increase in coagulation time in coagulological tests [ 21 ]. To activate clotting, a calcium chloride solution was used in the BRT test, since during blood stabilization, calcium ions necessary for coagulation bind to sodium citrate [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…To activate clotting, a calcium chloride solution was used in the BRT test, since during blood stabilization, calcium ions necessary for coagulation bind to sodium citrate [ 35 ]. The method was developed many years ago to control the level of unfractionated heparin (an activator of plasma inhibitors of coagulation factors) during artificial blood circulation [ 21 ]. At concentrations of 0.083 µg/mL and 0.830 µg/mL, all NMIC derivatives and NMIC2, NMIC3, NMIC4 and NMIC5 at concentrations of 8.300 µg/mL did not affect blood coagulation in the BRT test ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…Chitosan is a biopolymer derived from chitin, which has demonstrated great potential for use in tissue regeneration and controlled drug delivery [ 14 ]. Medical devices/materials in contact with blood are widely used in the diagnosis and treatment of various diseases [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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New N-Methylimidazole-Functionalized Chitosan Derivatives: Hemocompatibility and Antibacterial Properties

et al. 2023

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Novel imidazole derivatives of the low molecular weight chitosan N-(2-hydroxypropyl)-1H-1,2,3-triazol-4-yl)methyl)-1-methyl-1H-imidazol-3-ium chitosan chloride (NMIC) were synthesized using copper-catalyzed azide–alkyne cycloaddition (CuAAC). The degrees of substitution (DSs) for the new derivatives were 18–76%. All chitosan derivatives (2000 µg/mL) were completely soluble in water. The antimicrobial activity of the new compounds against E. coli and S. epidermidis was studied. The effect of chitosan derivatives on blood and its components was studied. NMIC samples (DS 34–76%) at a concentration <10 μg/mL had no effect on blood and plasma coagulation. Chitosan derivatives (DS 18–76%) at concentrations of ≥83 μg/mL in blood and ≥116.3 μg/mL in plasma resulted in a prolongation of the clotting time of blood and plasma, positively related to the DS. At concentrations up to 9.1 μg/mL, NMIC did not independently provoke platelet aggregation. The degree of erythrocyte hemolysis upon contact with NMIC samples (2.5–2500 μg/mL) was below 4%. The inhibition of blood/plasma coagulation indicates the promising use of the studied samples to modify the surface of medical materials in order to achieve thromboresistance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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New N-Methylimidazole-Functionalized Chitosan Derivatives: Hemocompatibility and Antibacterial Properties

et al. 2023

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“…The design and implementation of functional coatings is nowadays a topic of active research in a variety of healthrelated applications such as tissue engineering, bioelectronic devices, prevention of microbial proliferation, control of oxidative stress and inflammation, as well as medical diagnostics and therapy (theranostics) [1][2][3][4] and particularly in nanomedicine, in which the functionalization of nanostructures is of crucial importance to biocompatibility, blood circulation time and the ability to cross biological barriers. [5][6][7][8] Other fields of application include food packaging, material surfaces and interfaces modifications e. g., corrosion inhibition, metal removal through functionalized membranes till catalysis and energy applications. [9][10][11][12] For many applications, particularly in the biomedical sector, wet adhesion is an important requisite.…”

Section: Introduction: Functional Coatingsmentioning

confidence: 99%

Multifunctional coatings hinging on the catechol/amine interplay

Alfieri,

Panzella,

Napolitano

2023

Eur J Org Chem

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Design and implementation of functional coatings is a topic of active research in a variety of health‐related applications, most of which require wet adhesion. The powerful wet adhesion of mussel byssus proteins rich in DOPA and lysine residues provided a clue to realize that the combination of a catechol and an amine component has a specific role in the interfacial adhesion. From this natural model, polydopamine (PDA)‐based coatings have been developed that result from the oxidative polymerization of dopamine combining the catechol and amine functionalities in the same molecule. Covalent interactions resulting from Michael‐type addition or Schiff‐base formation of the polymeric products from dopamine oxidation as well as non‐covalent π‐stacking and cation‐π interactions exemplify the diverse mode of catechol/amine interplay that have been identified as responsible of the adhesion and cohesion properties of PDA. In the last decade coatings inspired to the same chemistry but using different starting materials have been explored particularly catechols of natural origin and different amine components, while mechanistic studies with model compounds have allowed to rationalize the structural requirements for adhesion and to expand the potential of these functional coatings.

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“…These materials encompass both synthetic biostable polymers, such as polyethylene and polyurethane (PU), as well as various biodegradable polymers like polycaprolactone (PCL) and polylactic acid, only to cite a few of them. [3,5,6] The utilization of such versatile polymers allows for the creation of high-quality medical devices that meet stringent performance requirements while considering factors such as biocompatibility, mechanical properties, and degradation characteristics.…”

Section: Introductionmentioning

confidence: 99%

Functional Zwitterionic Polyurethanes: State‐of‐the‐Art Review

Zhang,

Lv,

Zhao

et al. 2023

Macromol. Rapid Commun.

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Recent advancements in bioengineering and medical devices have been greatly influenced and dominated by synthetic polymers, particularly polyurethanes (PUs). PUs offer customizable mechanical properties and long‐term stability, but their inherent hydrophobic nature poses challenges in practically biological application processes, such as interface high friction, strong protein adsorption, and thrombosis. To address these issues, surface modifications of PUs for generating functionally hydrophilic layers have received widespread attention, but the durability of generated surface functionality is poor due to irreversible mechanical wear or biodegradation. As a result, numerous researchers have investigated bulk modification techniques to incorporate zwitterionic polymers or groups onto the main or side chains of PUs, thereby improving their hydrophilicity and biocompatibility. This comprehensive review presents an extensive overview of notable zwitterionic PUs (ZPUs), including those based on phosphorylcholine, sulfobetaine, and carboxybetaine. The review explores their wide range of biomedical applications, from blood‐contacting devices to antibacterial coatings, fouling‐resistant marine coatings, separation membranes, lubricated surfaces, and shape memory and self‐healing materials. Lastly, the review summarizes the challenges and future prospects of ZPUs in biological applications.

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Covalent coating strategy for enhancing the biocompatibility and hemocompatibility of blood-contacting medical materials

Cited by 8 publications

References 75 publications

New N-Methylimidazole-Functionalized Chitosan Derivatives: Hemocompatibility and Antibacterial Properties

New N-Methylimidazole-Functionalized Chitosan Derivatives: Hemocompatibility and Antibacterial Properties

Multifunctional coatings hinging on the catechol/amine interplay

Functional Zwitterionic Polyurethanes: State‐of‐the‐Art Review

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